vitamin-k-semiquinone-radical and Hypotension

Topics: Abdominal Pain; Acute Disease; Ankle Injuries; Arthralgia; Aspirin; Child; Consciousness Disorders; Diagnosis, Differential; Fatigue; Female; Hemorrhagic Disorders; Humans; Hyperammonemia; Hypoglycemia; Hypotension; Lactulose; Liver Failure; Reye Syndrome; Rheumatic Fever; Vitamin K

In recent years there have been advances in the management of non-variceal upper gastrointestinal bleeding that have helped reduce rebleeding and mortality. This document positioning of the Catalan Society of Digestologia is an update of evidence-based recommendations on management of gastrointestinal bleeding peptic ulcer.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Biomarkers; Combined Modality Therapy; Comorbidity; Contraindications, Drug; Crystalloid Solutions; Disease Management; Endoscopy, Gastrointestinal; Erythrocyte Transfusion; Erythromycin; Helicobacter Infections; Helicobacter pylori; Hemostatic Techniques; Humans; Hypotension; Intubation, Gastrointestinal; Isotonic Solutions; Liver Cirrhosis; Peptic Ulcer Hemorrhage; Physical Examination; Recurrence; Risk Factors; Vitamin K

Literature sources suggest that iv vitamin K is associated with significant adverse side effects. Systematic study and documentation is lacking. In this 2-y retrospective review, 100 sequential doses of iv administered vitamin K in 45 patients were identified by computer-generated pharmacy utilization reports in an adult teaching hospital. Charts were reviewed for complications following infusion of vitamin K, including specific abnormalities during the 90-min period post-administration: systolic blood pressure <90, heart rate <60 or >120, rash, shortness of breath, and syncope. Complete post-administration data were available for 60/100 doses. One episode of clinically insignificant transient hypotension was identified. Progress notes, discharge summaries and a concurrent survey of adverse drug reaction reports identified no complications related to the use of iv vitamin K. In this series, the iv administration of vitamin K did not pose a clinically significant risk.

Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Antifibrinolytic Agents; Female; Humans; Hypotension; Injections, Intravenous; Kentucky; Male; Medical Records; Middle Aged; Poisoning; Retrospective Studies; Vitamin K

Topics: Anemia; Angiography; Animals; Cats; Cerebral Hemorrhage; Dogs; Ecchymosis; Embolism; Fever; Gastrointestinal Hemorrhage; Hematoma; Hematuria; Hemorrhage; Hemothorax; Heparin; Humans; Hypotension; Ischemia; Leukocytosis; Shivering; Streptokinase; Thrombosis; Vitamin K

Topics: Antifibrinolytic Agents; Heparin Antagonists; Humans; Hypertension; Hypotension; Vitamin K