vitamin-k-semiquinone-radical and Hypocalcemia

Topics: Animals; Ascorbic Acid; Calcium, Dietary; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, Newborn, Diseases; Leg; Milk; Minerals; Muscle Cramp; Nutritional Requirements; Phosphorus; Pregnancy; Pregnancy Complications; Pyridoxine; Trace Elements; Vitamin A; Vitamin B Complex; Vitamin D; Vitamin D Deficiency; Vitamin E; Vitamin K; Vitamins

We examined the effect of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet. Eighty female Sprague-Dawley rats, 6 wk of age, were randomized by the stratified weight method into eight groups with 10 rats in each group: 0.5% (normal) or 0.1% (low) calcium diet, 0.5% or 0.1% calcium diet+vitamin K (vitamin K2, menatetrenone, 30 mg/100 g, food intake), 0.5% or 0.1% calcium diet+vitamin D (25 microg/100 g, food intake), and 0.5% or 0.1% calcium diet+vitamin K+vitamin D. The duration of the study was 10 wk. Vitamin K supplementation promoted the reduction in urinary calcium excretion and retarded the abnormal elevation of serum PTH level in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet. Vitamin D supplementation stimulated intestinal calcium absorption with prevention of the abnormal elevation of serum PTH levels and prevented hypocalcemia in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet. The stimulation of intestinal calcium absorption was associated with increased serum 1,25-dihydroxyvitamin D levels. An additive effect of vitamin K and vitamin D on intestinal calcium absorption was found only in rats fed a normal calcium diet. This study shows the differential effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet.

Topics: Animals; Calcitriol; Calcium; Calcium, Dietary; Dietary Supplements; Drug Interactions; Female; Homeostasis; Hypocalcemia; Intestinal Absorption; Parathyroid Hormone; Phosphorus; Rats; Rats, Sprague-Dawley; Vitamin D; Vitamin K

Topics: Anemia, Hypochromic; Avitaminosis; Body Weight; Carbohydrate Metabolism; Diarrhea; Disaccharides; Edema; Feces; Folic Acid; Glucose; Humans; Hypocalcemia; Hypokalemia; Hypoproteinemia; Intestinal Absorption; Intestine, Small; Iron; Malabsorption Syndromes; Vitamin A; Vitamin B 12; Vitamin K; Xylose

Topics: Anemia; Celiac Disease; Diet Therapy; Dwarfism; Edema; Glutens; Humans; Hypocalcemia; Hypokalemia; Hypoproteinemia; Hypoprothrombinemias; Kidney Diseases; Malabsorption Syndromes; Osteomalacia; Vitamin K

Topics: Alkaline Phosphatase; Biopsy; Blood; Blood Protein Disorders; Bone Diseases; Calcium Metabolism Disorders; Carbohydrate Metabolism; Folic Acid; Glutens; Humans; Hypocalcemia; In Vitro Techniques; Iron; Lipid Metabolism; Malabsorption Syndromes; Osteomalacia; Proteins; Radiography; Urine; Vitamin D; Vitamin K