vitamin-k-semiquinone-radical and Hyperemesis-Gravidarum

Topics: Bilirubin; Cholestyramine Resin; Diagnosis, Differential; Eclampsia; Female; Fetus; Hepatitis; Humans; Hyperemesis Gravidarum; Jaundice; Jaundice, Chronic Idiopathic; Liver Diseases; Pregnancy; Pregnancy Complications; Vitamin K

Vitamin K deficiency is associated with malnutrition in some complications, such as hyperemesis gravidarum, active gastrointestinal diseases, and psychological disorders. Maternal vitamin K deficiency can cause fetal bleeding, in particular, fetal intracranial hemorrhage. Although fetal hemorrhage is uncommon, severe damage to the fetus may be inevitable. We describe a pregnant woman with vitamin K deficiency possibly due to hyperemesis gravidarum. The patient was treated for the deficiency, and no fetal or neonatal hemorrhagic diseases were manifested.

Topics: Administration, Oral; Adult; Blood Coagulation; Blood Coagulation Tests; Dietary Supplements; Female; Fetal Blood; Humans; Hyperemesis Gravidarum; Live Birth; Maternal Nutritional Physiological Phenomena; Nutritional Status; Nutritional Support; Pregnancy; Pregnancy Complications, Hematologic; Treatment Outcome; Vitamin K; Vitamin K Deficiency

In rare cases, severe fetal vitamin K deficiency bleeding may occur in utero as a result of insufficient vitamin K placental transfer. We present a case of a 32-week-preterm infant born with severe intracranial hemorrhage to a pregnant woman who suffered from hyperemesis gravidarum. Neonatal hematologic status was compatible with vitamin K deficiency whereas the maternal coagulation function was normal. This case emphasizes the potential risk of fetal bleeding owing to vitamin K deficiency in pregnancies complicated with hyperemesis gravidarum. These women should be closely monitored and vitamin K prophylaxis might be considered.

Topics: Adult; Antifibrinolytic Agents; Female; Fetal Diseases; Gestational Age; Humans; Hyperemesis Gravidarum; Infant, Newborn; Intracranial Hemorrhages; Male; Pregnancy; Pregnancy Trimester, Third; Vitamin K; Vitamin K Deficiency

Topics: Adult; Female; Fetal Diseases; Gestational Age; Humans; Hydrocephalus; Hyperemesis Gravidarum; Intracranial Hemorrhages; Parenteral Nutrition, Total; Pregnancy; Ultrasonography, Prenatal; Vitamin K; Vitamin K Deficiency

Hyperemesis gravidarum is a condition of pregnancy characterized by excessive nausea and vomiting, which can be associated with malnutrition. Vitamin K deficiency is a known complication of malnutrition as well as a known cause of coagulopathy. To date, there is no reported case in the literature of vitamin K deficiency in hyperemesis gravidarum.. A woman at 15 weeks' gestation presented with hyperemesis gravidarum complicated by an episode of severe epistaxis. Investigation revealed coagulopathy secondary to vitamin K deficiency. The coagulopathy resolved after vitamin K replacement, with complete correction of all clotting factors.. Vitamin K deficiency and coagulopathy should be considered in women with hyperemesis gravidarum who present with a bleeding diathesis. Prophylactic vitamin K replacement should be considered in cases in which hyperemesis is severe and protracted.

Topics: Adult; Blood Coagulation Disorders; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Vitamin K; Vitamin K Deficiency

Topics: Ascorbic Acid; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Vitamin K

Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Diagnosis; Diet; Diet Therapy; Female; gamma-Globulins; Hepatitis; Hepatitis A; Hepatitis B virus; Hyperemesis Gravidarum; Liver Function Tests; Lupus Erythematosus, Systemic; Methyltestosterone; Norethindrone; Pneumonia; Prednisone; Pregnancy; Pregnancy Complications, Infectious; Pyelonephritis; Thioguanine; Toxicology; Vitamin K