vitamin-k-semiquinone-radical and Hepatitis-B

Topics: Animals; Blood Coagulation Factors; Chemical Fractionation; Chromatography, DEAE-Cellulose; Dogs; Factor IX; Factor IXa; Factor VII; Factor VIII; Factor X; Hemophilia B; Hepatitis B; Hepatitis C; Humans; Partial Thromboplastin Time; Prothrombin; Thrombosis; Vitamin K

Topics: Disseminated Intravascular Coagulation; Factor IX; Factor VII; Factor VIII; Factor X; Factor X Deficiency; Half-Life; Hemophilia B; Hemostasis; Hepatitis B; Hepatitis, Viral, Human; Humans; Infant, Newborn; Prothrombin; Vitamin K; Vitamin K Deficiency Bleeding

Topics: Adult; Altitude; Bilirubin; Biological Transport; Erythrocyte Aging; Female; Hemolysis; Hepatitis B; Hexosyltransferases; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Infant, Newborn; Jaundice; Liver; Novobiocin; Portacaval Shunt, Surgical; Pregnancy; Vitamin K

Topics: Adrenocorticotropic Hormone; Amino Acids; Cholestyramine Resin; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; gamma-Globulins; Hepatitis A; Hepatitis B; Humans; Pruritus; Rest; Vitamin B 12; Vitamin E; Vitamin K

To evaluate the potential diagnostic value of growth differentiation factor 15 (GDF15) alone and its combination with protein induced by vitamin K absence-II (PIVKA-II) and alpha-fetoprotein (AFP) for hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).. Serum levels of GDF15, PIVKA-II, and AFP were measured in 110 patients with HBV-associated HCC, 70 patients with HBV-related liver cirrhosis (LC), 70 patients with chronic hepatitis B (CHB), and 110 healthy patients.. Serum GDF15 was positively related to the levels of PIVKA-II and AFP in patients with HCC (r = 0.352 and r = 0.378; all P <.0001). When the receiver operating characteristic (ROC) curve was plotted for patients with HCC vs all control patients, serum GDF15 had diagnostic parameters of an area under the curve (AUC) of 0.693, a sensitivity of 67.30%, and a specificity of 66.70%, which were lower than parameters for PIVKA-II and AFP (all P <.0001). When the ROC curve was plotted for patients with HCC vs patients with LC, the combination of GDF15 and PIVKA-II had the highest diagnostic accuracy of AUC and specificity as compared with other combinations (all P <.0001).. We found that GDF15 is a potent serum marker for the detection of HBV-associated HCC and that PIVKA-II combined with GDF15 can improve diagnostic accuracy for HBV-associated HCC.

Topics: alpha-Fetoproteins; Biomarkers, Tumor; Carcinoma, Hepatocellular; Growth Differentiation Factor 15; Hepatitis B; Hepatitis B virus; Humans; Liver Cirrhosis; Liver Neoplasms; Protein Precursors; Prothrombin; ROC Curve; Vitamin K; Vitamins

The clinical presentation of acute hepatitis B virus (HBV) infection is usually related to the onset of liver failure and damage. Anaemia may occur, but it is only rarely attributed to haemolysis. The authors report about the case of a 41-year-old woman with the diagnosis of acute HBV infection and coagulopathy (without encephalopathy) who developed non-immune haemolytic anaemia. Total recovery of the analytical liver profile, coagulopathy and anaemia was achieved through treatment targeting HBV.This case shows that, although rare, non-immune haemolytic anaemia may occur in association with acute HBV infection and that HBV suppression seems to lead to progressive anaemia resolution.

Topics: Acetylcysteine; Acute Disease; Adult; Anemia, Hemolytic; Antiviral Agents; Female; Folic Acid; Guanine; Hepatitis B; Humans; Treatment Outcome; Vitamin B Complex; Vitamin K; Vitamins

To evaluate the role of bilharzial hepatic fibrosis--whether pure or combined with chronic hepatitis B virus infection--on the functional activity of vitamin K dependent coagulation proteins.. Coagulation screening using prothrombin time (PT), partial thromboplastin time (PTT), and thrombin time (TT) was carried out on 31 patients with endemic Egyptian hepatosplenomegaly and on 14 healthy controls. The functional activities of factors II, VII, IX and X and protein C were measured. Patients were classified as pure hepatosplenic schistosomiasis (n = 17) and schistosomiasis with concomitant chronic hepatitis B virus infection (n = 14).. Prolongation of the PT and PTT were noticed in bilharzial patients compared with the controls. The increase in the TT remained within the upper range of normal. Factors II, VII, IX and X and protein C functional activities were significantly reduced in all groups studied.. The decreased activity of vitamin K dependent coagulation factors might be partially offset by the reduced activity of circulating protein C which tends to establish a haemostatic balance at a lower level in endemic Egyptian hepatosplenomegaly. No significant difference could be shown between the pure and mixed cases. Schistosomal coagulopathy is therefore not necessarily aggravated by chronic hepatitis B virus infection.

Topics: Adolescent; Adult; Blood Coagulation Factors; Blood Coagulation Tests; Child; Egypt; Hepatitis B; Hepatomegaly; Humans; Liver Cirrhosis; Male; Middle Aged; Schistosomiasis; Splenomegaly; Vitamin K

Topics: Adult; Angiography; Heparin; Hepatitis B; Humans; Liver Cirrhosis; Male; Portal System; Splenectomy; Splenic Vein; Thrombophlebitis; Vitamin K

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Exchange Transfusion, Whole Blood; Female; Hepatic Encephalopathy; Hepatitis A; Hepatitis B; Humans; Hydrocortisone; Liver Diseases; Male; Middle Aged; Neomycin; Thiamine; Vitamin K