vitamin-k-semiquinone-radical and Hemothorax

Topics: Acenocoumarol; Amino Acid Substitution; Anticoagulants; Factor IX; Hematoma; Hemothorax; Humans; International Normalized Ratio; Laryngeal Diseases; Male; Middle Aged; Mutation, Missense; Pedigree; Radiography; Vitamin K

Topics: Blood Coagulation Tests; Diagnosis, Differential; Hematocele; Hemothorax; Humans; Infant, Newborn; Male; Vitamin K; Vitamin K Deficiency Bleeding

Topics: 4-Hydroxycoumarins; Adult; Blood Transfusion; Compartment Syndromes; Female; Hemothorax; Humans; Infusions, Intravenous; International Normalized Ratio; Leg; Plasma; Rodenticides; Suicide, Attempted; Ultrasonography, Doppler; Vitamin K

Topics: Administration, Oral; Hemothorax; Humans; Infant, Newborn; Male; Vitamin K; Vitamin K Deficiency; Vitamin K Deficiency Bleeding

A three day old male, term infant with hemothorax due to hemorrhagic disease of the newborn was treated successfully with vitamin K and thoracocentesis. Exclusive breast feeding and absence of vitamin K prophylaxis were important diagnostic clues, although hemothorax as a sole manifestation of hemorrhagic disease of the newborn is rare. This case highlighted the good prognosis of an uncommon complication when prompt diagnosis and appropriate treatment are instituted. The importance of vitamin K prophylaxis to all newborns is emphasized.

Topics: Drainage; Hemothorax; Humans; Infant, Newborn; Male; Punctures; Radiography, Thoracic; Thoracic Surgery; Vitamin K; Vitamin K Deficiency Bleeding

Topics: Administration, Oral; Hemothorax; Humans; Infant; Male; Vitamin K; Vitamin K Deficiency

Topics: Administration, Oral; Age Factors; Biliary Tract Diseases; Cerebral Hemorrhage; Ecchymosis; Female; Gastrointestinal Hemorrhage; Hemorrhage; Hemothorax; Humans; Infant; Infant, Newborn; Liver Diseases; Male; Sweden; Time Factors; Vitamin K; Vitamin K Deficiency

The cause of a fatal condition characterized by hemorrhagic cardiomyopathy, hemothorax, and coagulation defects in hysterectomy-derived male mice was investigated. Microscopic heart alterations included multifocal hemorrhage and necrosis with variable degrees of acute inflammation and fibroplasia that were most severe in the region of the atrioventricular junction. A spontaneous outbreak was arrested by increasing menadione Na-bisulfite (vitamin K) in the feed to 20 ppm. The complete syndrome including hemorrhagic cardiomyopathy was readily reproduced in germ-free male mice given a vitamin K-free diet, and in conventional male and female mice given Warfarin in the diet. We concluded that the cause of this condition was vitamin K deficiency.

Topics: Animals; Blood Coagulation Disorders; Cardiomyopathies; Female; Hemorrhagic Disorders; Hemothorax; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Myocardium; Vitamin K; Vitamin K Deficiency; Warfarin

Topics: Animals; Blood Transfusion, Autologous; Dicumarol; Dog Diseases; Dogs; Female; Hemothorax; Male; Thoracic Injuries; Vitamin K

Topics: Blood Coagulation Disorders; Blood Transfusion; Drainage; Female; Hemoglobinometry; Hemorrhage; Hemothorax; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Mediastinum; Pleura; Radiography; Rupture; Thymus Gland; Vitamin K

Topics: Aged; Anticoagulants; Biopsy, Needle; Hemothorax; Humans; Male; Middle Aged; Radiography; Renal Dialysis; Vitamin K

Topics: Blood Transfusion; Drainage; Female; Hemothorax; Humans; Infant, Newborn; Infant, Newborn, Diseases; Vitamin K; Vitamin K Deficiency Bleeding

Topics: Cardiac Catheterization; Factor VII; Heart Valve Prosthesis; Hemostasis; Hemothorax; Humans; Methods; Prothrombin Time; Thromboembolism; Vitamin K; Warfarin

Topics: Anemia; Angiography; Animals; Cats; Cerebral Hemorrhage; Dogs; Ecchymosis; Embolism; Fever; Gastrointestinal Hemorrhage; Hematoma; Hematuria; Hemorrhage; Hemothorax; Heparin; Humans; Hypotension; Ischemia; Leukocytosis; Shivering; Streptokinase; Thrombosis; Vitamin K

Topics: Animals; Animals, Laboratory; Clostridium perfringens; Colon; Enterococcus faecalis; Escherichia coli; Factor V; Factor VII; Factor X; Female; Germ-Free Life; Hemorrhagic Disorders; Hemothorax; Ileum; Lactobacillus; Male; Mice; Myocardium; Pericardium; Proteus; Prothrombin; Rats; Rodent Diseases; Vitamin K