vitamin-k-semiquinone-radical and Hemoptysis

Hemoptysis is a complication in cystic fibrosis (CF) patients, and is associated with pulmonary exacerbations and hospitalizations. Pancreatic insufficiency is common in CF patients, and therefore these patients may benefit from the use of vitamin K therapy.. This was an observational study conducted in adult CF patients aiming to describe the utilization of vitamin K therapy in the setting of hemoptysis during an acute CF pulmonary exacerbation. An evaluation of hospital length of stay, time until the next pulmonary exacerbation, and 30-day re-admission rates were evaluated in CF patients who presented with hemoptysis and received vitamin K therapy.. The average dose of vitamin K therapy was 10 mg for an average duration of 4.9 ± 0.55 days for 38 adult CF patients included in this cohort. The median length of stay among patients who received vitamin K therapy was 8 days (IQR: 6-12 days). The median time until next hospital admission was 127 days (95% CI: 71.4 to 182.6 days), and the 30-day readmission rates were 7.89%. Two patients developed a thromboembolism after receiving vitamin K therapy.. Evidence for the use of vitamin K therapy in the setting of CF-related hemoptysis remains unclear, and warrants further safety and efficacy evaluation. Further prospective studies are needed to determine the appropriateness of dosing and duration of vitamin K therapy, as well as determining its role in the setting of the varying levels of hemoptysis during a pulmonary CF exacerbation.

Topics: Adult; Cystic Fibrosis; Female; Hemoptysis; Humans; Length of Stay; Male; Middle Aged; Patient Readmission; Retrospective Studies; Thromboembolism; Vitamin K

A 91-year-old Caucasian man on warfarin for atrial fibrillation presented in view of sudden-onset haemoptysis with fresh bleeding with clots immediately after having eaten a piping-hot traditional cheesecake (pastizz) and burning the soft-palate of his mouth. The haemoptysis had resolved by the time that the patient had arrived to hospital. On examination, a 2 cm by 2 cm dark red, solitary mass could be seen just anterior to the uvula. This was not causing any pain or discomfort to the patient. Blood results were mostly unremarkable except for a raised international normalised ratio (INR) of 3.53. The patient was administered 5 mg vitamin K orally in attempt to lower the INR level and warfarin was subsequently omitted for 7 days. He was also prescribed oral steroids on discharge. The lesion resolved in 7 days and warfarin was restarted then with no further consequences.

Topics: Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Blood Coagulation; Burns; Food; Hematoma; Hemoptysis; Hot Temperature; Humans; International Normalized Ratio; Male; Palate, Soft; Uvula; Vitamin K; Warfarin

Intra-alveolar bleeding is a rare and severe medical emergency due to numerous causes. We report the clinical case of a patient who could contribute to extend the literature on this subject. The study included a 62-year old man, with a history of a trial fibrillation, under anti-vitamins K antagonist admitted with dyspnoea of sudden onset associated with haemoptysis and practising self-medication using non-steroidal anti-inflammatory drugs. X-rays and chest scan showed diffuse bilateral alveolar opacities. Haemostatic screening tests on admission showed non-coagulable INR. The diagnosis of intra-alveolar bleeding was clinically and radiologically suspected and then confirmed by bronchial endoscopy with broncho-alveolar lavage (BAL) which detected uniformly hemorrhagic liquid. Previous studies of similar complications occurring after anti-vitamins K antagonists assumption are rare. In conclusion, it seems very important to emphasize the interest of strict and optimal clinico-biological monitoring of patients treated in anti-vitamins K antagonists to avoid an overdose which could contribute to a life-threatening severe haemorrhagic event.

Topics: Acenocoumarol; Anticoagulants; Dyspnea; Hemoptysis; Hemorrhage; Humans; Male; Middle Aged; Pulmonary Alveoli; Vitamin K

An 80-year-old female with a history of hypertension and atrial fibrillation had been receiving warfarin anticoagulant therapy and had stably maintained an international normalized ratio (INR) within the 2.0-3.0 range. Due to dental extractions, she was prescribed aspirin (100 mg/day) as an alternative therapy to warfarin. Three days later, the patient complained of hemoptysis without obvious inducement and the INR was 3.51. The aspirin was immediately discontinued and intravenous vitamin K was administered. Hemoptysis did not reappear and the INR returned to the normal limits. According to the Drug Interaction Probability Scale, a causal relationship between aspirin and warfarin and an increased INR value is possible.

Topics: Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Drug Interactions; Female; Hemoptysis; Humans; International Normalized Ratio; Tooth Extraction; Vitamin K; Warfarin

Topics: Anticoagulants; Hemoptysis; Humans; Male; Middle Aged; Phenprocoumon; Pulmonary Alveoli; Vitamin K; Vitamin K Deficiency

Topics: Beriberi; Heart; Hemoptysis; History, 20th Century; Humans; Italy; Liver Diseases; Niacinamide; Nicotinic Acids; Pellagra; Periodicals as Topic; Polyneuropathies; Vitamin B Complex; Vitamin K; Vitamins

Topics: Adolescent; Adult; Anti-Bacterial Agents; Blood Transfusion; Child; Child, Preschool; Cystic Fibrosis; Drainage; Female; Hemoptysis; Humans; Male; Ohio; Physical Therapy Modalities; Prognosis; Recurrence; Vitamin K

Topics: Anti-Bacterial Agents; Blood Cell Count; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelets; Child; Cystic Fibrosis; Fibrinolysis; Gastrointestinal Hemorrhage; Hemoptysis; Hepatomegaly; Humans; Liver; Liver Function Tests; Lung; Prospective Studies; Prothrombin Time; Splenomegaly; Thrombocytopenia; Thromboplastin; Vitamin K

Topics: Anticoagulants; Hematuria; Hemoptysis; Humans; Lung Diseases; Male; Middle Aged; Radiography, Thoracic; Vitamin K

Topics: Anti-Glomerular Basement Membrane Disease; Cerebrospinal Fluid Rhinorrhea; Diagnosis, Differential; Glomerulonephritis; Hematuria; Hemoptysis; Hemorrhage; Humans; Hydrocortisone; Lung Diseases; Prednisone; Vitamin K

Topics: Antifibrinolytic Agents; Hemoptysis; Humans; Naphthoquinones; Tuberculosis; Tuberculosis, Pulmonary; Vitamin K; Vitamin K 1