vitamin-k-semiquinone-radical and Hemoperitoneum

Ovarian hemorrhage with hemoperitoneum is a rare but serious complication of ovulation related to rupture of either the corpus luteum or functional cyst. It is due to treatment using oral indirect anticoagulant and specifically affects young women.. We review cases that were reported since the initial description by Weseley in 1957. The main indications for oral indirect anticoagulant are thrombophlebitis and valvular cardiac prosthesis. Pelvic pain with peritoneal irritation is the most common symptom in more than one third of the patients. An initial collapse is reported in 22% of the cases. Surgery is the main treatment. Mortality is 3% and recurrences occur in nearly 25% of the patients.. Potential ovarian hemorrhage should be investigated when a woman taking oral indirect anticoagulant develops acute abdominal pain. Surgery should be conservative and whenever possible, should include celioscopy. Systematic ovarian blockade should be discussed in women taking long-term oral indirect anticoagulant.

Topics: Administration, Oral; Adult; Anticoagulants; Female; Hemoperitoneum; Hemorrhage; Humans; Ovarian Cysts; Ovarian Diseases; Pelvic Pain; Rupture; Vitamin K

Spontaneous hematoma of transverse mesocolon is a rare complication of anticoagulant treatment with vitamin K. We report the case of spontaneous hematoma of right angle of the transverse mesocolon associated with a hemoperitoneum in a 32-year-old patient treated by fluindione for pulmonary embolism. The diagnosis must be made urgently. The abdominal ultrasound and the scanning confirm the diagnosis. It is important to note that surgery is indicated only in the case of complications such as the risk of rupture of the hematoma.

Topics: Adult; Anticoagulants; Female; Hematoma; Hemoperitoneum; Humans; Mesocolon; Phenindione; Pulmonary Embolism; Vitamin K

We report a case of a 50-year-old woman, taking antivitamin K for double mitro-aortic valvular replacement, having presented a clinical picture of acute cholecystitis with marked hypotension. The radiological and biologic exams showed a deep hypocoagulability, vesicular gallstones, a haemoperitoneum and retroperitoneal haematoma. After correction of biological anomalies, the patient was operated. The gallbladder was distended containing large clots and four stones without any evidence of perforation. One of the gallstones led to cystic duct obstruction. Haemocholecyst is a rare complication of anticoagulant therapy, which may occur in the setting of gallbladder stones. The usual complication was the vesicular perforation. In spite of its rarity, haemocholecyst should be suspected when an anticoagulant treated patient presents symptoms of acute cholecystis with or without haemorrhagic shock.

Topics: Adult; Anticoagulants; Bile Ducts; Cholecystitis; Female; Heart Valve Prosthesis Implantation; Hematoma; Hemoperitoneum; Humans; Vascular Diseases; Vitamin K

Brodifacoum is a 4-hydroxycoumarin derivative that is commonly used as a rodenticide. Human exposures have produced severe coagulopathies resulting in hematuria, gastrointestinal bleeding, intracranial hemorrhage, and death. This is the first report of spontaneous hemoperitoneum secondary to brodifacoum ingestion. The patient was successfully managed with fresh frozen plasma, packed red blood cells, and vitamin K1. No surgical intervention was performed. The patient required ongoing daily vitamin K1 therapy for longer than 6 months.

Topics: 4-Hydroxycoumarins; Adult; Blood Component Transfusion; Drug Overdose; Erythrocyte Transfusion; Female; Hemoperitoneum; Humans; Plasma; Poisoning; Rodenticides; Vitamin K

Acute haemocholecyst is a rare disorder but often reported in patients with gallstones. Rupture of the gallbladder causing hypovolaemic shock secondary to massive intraperitoneal bleeding has been reported in about fifty patients to date. We report a new case of haemocholecyst with rupture of the gallbladder in a patient with gallstones treated by anticoagulant therapy. This case is unusual in terms of the nature of the gallbladder disease: massive gangrene with complicating hemorrhage and destruction of deficient regions of the wall of the gallbladder induced an infrahepatic haematoma without hypovolemic shock, in contrast with the massive intraperitoneal hemorrhage reported in other cases.

Topics: Aged; Anticoagulants; Cholelithiasis; Female; Hematoma; Hemoperitoneum; Humans; Vitamin K

Topics: Diet Therapy; Ethyl Biscoumacetate; Hematoma; Hemoperitoneum; Humans; Intestinal Obstruction; Jejunum; Male; Middle Aged; Prothrombin; Thrombosis; Vitamin K

Topics: Blood Coagulation Disorders; Blood Transfusion; Exchange Transfusion, Whole Blood; Female; Gastrointestinal Hemorrhage; Hemoperitoneum; Humans; Infant, Newborn; Infant, Newborn, Diseases; Laparotomy; Liver; Prothrombin Time; Rupture; Vitamin K

Topics: Autopsy; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Transfusion; Female; Fetal Diseases; Fibrinogen; Hemoperitoneum; Hemorrhage; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Infusions, Parenteral; Penicillins; Pregnancy; Punctures; Respiration, Artificial; Vitamin K

Topics: Aged; Electrocardiography; Hemoperitoneum; Humans; Intestinal Obstruction; Male; Mesenteric Vascular Occlusion; Middle Aged; Myocardial Infarction; Vitamin K; Warfarin