Compounds > vitamin-k-semiquinone-radical

vitamin-k-semiquinone-radical and Genital-Neoplasms--Female

vitamin-k-semiquinone-radical has been researched along with Genital-Neoplasms--Female* in 2 studies

Other Studies

2 other study(ies) available for vitamin-k-semiquinone-radical and Genital-Neoplasms--Female

Article	Year
Direct oral anticoagulants are effective and safe for the treatment of venous thromboembolism associated with gynecological cancers. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019, Volume: 147, Issue:2 To retrospectively review the efficacy and safety of novel direct oral anticoagulants (DOACs) and compare the results with those of vitamin K antagonists (VKA) when used in clinical practice to treat venous thromboembolism (VTE) because there is insufficient evidence regarding its use in patients with gynecological cancers.. A study was conducted of patients diagnosed with gynecological cancers at Osaka University Hospital between January 2010 and December 2017. The medical records of those who suffered from deep venous thrombosis (DVT) and/or pulmonary embolism (PE) were retrospectively reviewed.. Among the 1698 cases of gynecological cancers, 107 (6.3%) cases were diagnosed as having VTE. A total of 34 (31.8%) patients presented DVT plus PE and 73 (68.2%) patients had DVT alone. Fifty-four cases were treated with DOACs and 53 with VKA. Although 3 of the 53 patients (5.7%) in the VKA group developed recurrent VTE, only 1 (1.9%) patient in the DOAC group showed clinically relevant bleeding from a tumor penetrating the rectum. DOACs were non-inferior to VKA with respect to the composite outcome, including recurrent venous thrombosis and relevant bleeding (hazard ratio 0.31, 95% confidence interval 0.03-3.12, P=0.363).. DOACs can be effectively and safely used in VTE patients with gynecological cancers. Topics: Administration, Oral; Aged; Anticoagulants; Female; Genital Neoplasms, Female; Heparin; Humans; Middle Aged; Retrospective Studies; Venous Thromboembolism; Vitamin K	2019
Research note: lack of an effect of high levels of menadione on tumor development in Japanese quail females. Poultry science, 1991, Volume: 70, Issue:11 The objective of the experiment was to study the influence of a high but nontoxic dietary level of menadione (vitamin K3) on the incidence of leiomyomas and leiomyosarcomas in the oviduct of females from various lines of Japanese quail. Analyzed values of vitamin K3 per 1,000 kg of feed were 7.37 g in the control diet, and 149.6, 1,722, and 3,722 g for the experimental diets from 0 to 4, 5 to 8, and after 8 wk of age, respectively. Females were killed after they had been in production for 158 days. Females from three large-bodied lines had a greater incidence of smooth muscle tumors than those from a smaller randombred control line. The high dietary level of vitamin K3 had no influence on tumor development. Topics: Animals; Bird Diseases; Body Weight; Coturnix; Female; Genital Neoplasms, Female; Leiomyoma; Leiomyosarcoma; Oviposition; Vitamin K	1991

Article

Year

Direct oral anticoagulants are effective and safe for the treatment of venous thromboembolism associated with gynecological cancers.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019, Volume: 147, Issue:2

To retrospectively review the efficacy and safety of novel direct oral anticoagulants (DOACs) and compare the results with those of vitamin K antagonists (VKA) when used in clinical practice to treat venous thromboembolism (VTE) because there is insufficient evidence regarding its use in patients with gynecological cancers.. A study was conducted of patients diagnosed with gynecological cancers at Osaka University Hospital between January 2010 and December 2017. The medical records of those who suffered from deep venous thrombosis (DVT) and/or pulmonary embolism (PE) were retrospectively reviewed.. Among the 1698 cases of gynecological cancers, 107 (6.3%) cases were diagnosed as having VTE. A total of 34 (31.8%) patients presented DVT plus PE and 73 (68.2%) patients had DVT alone. Fifty-four cases were treated with DOACs and 53 with VKA. Although 3 of the 53 patients (5.7%) in the VKA group developed recurrent VTE, only 1 (1.9%) patient in the DOAC group showed clinically relevant bleeding from a tumor penetrating the rectum. DOACs were non-inferior to VKA with respect to the composite outcome, including recurrent venous thrombosis and relevant bleeding (hazard ratio 0.31, 95% confidence interval 0.03-3.12, P=0.363).. DOACs can be effectively and safely used in VTE patients with gynecological cancers.

Topics: Administration, Oral; Aged; Anticoagulants; Female; Genital Neoplasms, Female; Heparin; Humans; Middle Aged; Retrospective Studies; Venous Thromboembolism; Vitamin K

2019

Research note: lack of an effect of high levels of menadione on tumor development in Japanese quail females.

Poultry science, 1991, Volume: 70, Issue:11

The objective of the experiment was to study the influence of a high but nontoxic dietary level of menadione (vitamin K3) on the incidence of leiomyomas and leiomyosarcomas in the oviduct of females from various lines of Japanese quail. Analyzed values of vitamin K3 per 1,000 kg of feed were 7.37 g in the control diet, and 149.6, 1,722, and 3,722 g for the experimental diets from 0 to 4, 5 to 8, and after 8 wk of age, respectively. Females were killed after they had been in production for 158 days. Females from three large-bodied lines had a greater incidence of smooth muscle tumors than those from a smaller randombred control line. The high dietary level of vitamin K3 had no influence on tumor development.

Topics: Animals; Bird Diseases; Body Weight; Coturnix; Female; Genital Neoplasms, Female; Leiomyoma; Leiomyosarcoma; Oviposition; Vitamin K

1991