vitamin-k-semiquinone-radical and Ecchymosis

To review the published literature to determine the efficacy and safety of homeopathic agents or vitamins in reducing ecchymosis after oculofacial surgery or laser surgery.. A literature search was conducted in the PubMed database initially in December 2019 and updated in March 2020 to identify all studies in the English language literature on the use of homeopathic agents or vitamins in oculofacial procedures, including laser surgery. The search yielded 124 citations, and 11 articles met all inclusion criteria for this assessment. A panel methodologist then assigned a level of evidence rating for each study. Eleven studies met inclusion criteria; 9 were rated level I, and 2 were rated level III.. The agents studied in the articles identified included oral or topical Arnica montana (AM), oral Melilotus extract, topical vitamin K oxide, and topical AM combined with Rhododendron tomentosum. Metrics to describe ecchymosis varied. In 7 controlled studies, perioperative AM provided no or negligible benefit versus placebo. In 2 studies, vitamin K cream was equivalent to placebo. One study of oral Melilotus extract had less ecchymosis compared with controls in paranasal and eyelid ecchymosis at postoperative day (POD) 7, but not at PODs 1 and 4. A lone cohort study of combined topical AM and R. tomentosum lacked objective metrics and adequate controls. No serious side effects from administration of homeopathic agents or vitamins were identified.. The current literature does not support the use of AM, vitamin K oxide, R. tomentosum, or Melilotus extract for reducing ecchymosis after oculofacial surgery or pulsed dye laser surgery.

Topics: Academies and Institutes; Ecchymosis; Eyelid Diseases; Face; Humans; Materia Medica; Ophthalmologic Surgical Procedures; Ophthalmology; Paranasal Sinus Diseases; Plant Extracts; Technology Assessment, Biomedical; United States; Vitamin K

Topics: Animals; Blood Coagulation Disorders; Blood Coagulation Factors; Clofibrate; Ecchymosis; Humans; Male; Middle Aged; Prothrombin Time; Vitamin E; Vitamin K; Warfarin

Topics: Ecchymosis; Female; Humans; Infant, Extremely Premature; Infant, Newborn; Nicolau Syndrome; Vitamin K

Topics: Airway Obstruction; Antifibrinolytic Agents; Blood Coagulation Factors; Ecchymosis; Factor X Deficiency; Factor XI Deficiency; Female; Hematoma; Humans; Laryngoscopy; Middle Aged; Treatment Outcome; Vitamin K; Vitamin K Deficiency Bleeding

A 17-year-old woman, with a history of three operations on the upper gut in early life and intermittent diarrhoea, presented with a history of epistaxis and leg ecchymosis for the previous 3 months. Initial investigation revealed mild anaemia, low serum albumin, moderately elevated aminotransferases and an exceedingly prolonged prothrombin time (PT) which was promptly shortened to normal by intravenous vitamin K. Additional investigations revealed a grossly abnormal glucose hydrogen breath test, a dilated duodenum and deficiencies of vitamins A, D and E. Repeated courses of antimicrobial agents caused prompt but transient shortening of PT and eventually a duodenal-jejunal anastomosis was performed. Since then, up to 36 months later, the patient has been in good general health and PT has been consistently normal with no vitamin K supplementation. Small intestinal bacterial overgrowth has previously been associated with several conditions but this is the first description of its association with vitamin K-responsive coagulopathy.

Topics: Adolescent; Anastomosis, Surgical; Blind Loop Syndrome; Blood Coagulation Disorders; Breath Tests; Dietary Supplements; Ecchymosis; Epistaxis; Female; Glucose; Humans; Hydrogen; Leg; Time Factors; Treatment Outcome; Vitamin K

Topics: Administration, Oral; Age Factors; Biliary Tract Diseases; Cerebral Hemorrhage; Ecchymosis; Female; Gastrointestinal Hemorrhage; Hemorrhage; Hemothorax; Humans; Infant; Infant, Newborn; Liver Diseases; Male; Sweden; Time Factors; Vitamin K; Vitamin K Deficiency

Topics: 4-Hydroxycoumarins; Adult; Blood Coagulation; Drug Therapy, Combination; Ecchymosis; Female; Humans; Phenobarbital; Prothrombin Time; Rodenticides; Time Factors; Vitamin K

Topics: Alanine Transaminase; Anemia; Aspartate Aminotransferases; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelets; Blood Transfusion; Cerebral Hemorrhage; Ecchymosis; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Prognosis; Prothrombin; Prothrombin Time; Seizures; Spinal Puncture; Subarachnoid Hemorrhage; Thrombin; Thromboplastin; Vitamin K

Topics: Age Factors; Aged; Anemia; Anti-Bacterial Agents; Anticoagulants; Blood Coagulation Disorders; Blood Coagulation Tests; Ecchymosis; Female; Hematuria; Humans; Liver Diseases; Malabsorption Syndromes; Male; Middle Aged; Vitamin K; Vitamin K Deficiency

Topics: Anemia; Angiography; Animals; Cats; Cerebral Hemorrhage; Dogs; Ecchymosis; Embolism; Fever; Gastrointestinal Hemorrhage; Hematoma; Hematuria; Hemorrhage; Hemothorax; Heparin; Humans; Hypotension; Ischemia; Leukocytosis; Shivering; Streptokinase; Thrombosis; Vitamin K

Topics: Anticoagulants; Blood Transfusion; Ecchymosis; Hematoma, Epidural, Spinal; Hematuria; Hemorrhage; Heparin Antagonists; Humans; Myelography; Radiography; Spinal Cord; Spinal Puncture; Toxicology; Vitamin K

Topics: Barium Sulfate; Celiac Disease; Colonic Diseases; Congenital Abnormalities; Constriction, Pathologic; Dietary Fats; Ecchymosis; Glucose Tolerance Test; Humans; Infant; Intestinal Obstruction; Jejunum; Malabsorption Syndromes; Pathology; Rotation; Surgical Procedures, Operative; Vitamin A; Vitamin K; Xylose