vitamin-k-semiquinone-radical and Contusions

Dermatological procedures can result in disfiguring bruises that resolve slowly.. To assess the comparative utility of topical formulations in hastening the resolution of skin bruising.. Healthy volunteers, age range 21-65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)-10 (most)] in standardized photographs immediately after bruise creation and at week 2.. There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P=0·016). Pairwise comparisons indicated that the mean improvement associated with 20% arnica was greater than with white petrolatum (P=0·003), and the improvement with arnica was greater than with the mixture of 1% vitamin K and 0·3% retinol (P=0·01). Improvement with arnica was not greater than with 5% vitamin K cream, however.. Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

Topics: Administration, Topical; Adult; Aged; Arnica; Contusions; Double-Blind Method; Emollients; Female; Humans; Lasers; Male; Middle Aged; Observer Variation; Petrolatum; Photography; Phytotherapy; Plant Preparations; Vitamin K; Young Adult

Topics: Administration, Topical; Adult; Contusions; Double-Blind Method; Female; Humans; Male; Middle Aged; Ointments; Stress, Mechanical; Suction; Vitamin K

Pulsed dye laser treatment and other cosmetic procedures result in significant bruising. Claims have been made regarding the efficacy of topical vitamin K in both preventing and speeding the clearing of bruising; however, well-controlled studies are lacking.. The purpose of this study is to evaluate the effects of topical vitamin K versus placebo in the prevention and clearing of laser-induced purpura.. A total of 22 patients were enrolled in this double-blind randomized placebo-controlled study. The patients were divided into pretreatment and posttreatment groups; the 11 patients in the former group applied vitamin K cream to half of their face and vehicle alone to the other half of their face twice daily for 2 weeks before laser treatment. The latter group followed the same procedure for 2 weeks after laser treatment. On day 0, all subjects underwent laser treatment for facial telangiectases using a 585-nm pulsed dye laser. Bruising was rated by the both the patient and physician by means of a visual analogue scale on days 0, 3, 7, 10, 14, and 17.. The side of the face treated with topical vitamin K before laser therapy showed no significant difference in bruising as compared to placebo. However, the side of the face treated with vitamin K cream after laser treatment had significantly lower scores of bruising severity when compared with the side treated with placebo.. Although pretreatment with vitamin K did not prevent bruising after laser treatment, use of vitamin K cream after laser treatment did reduce the severity of bruising, particularly in the initial days of application.

Topics: Administration, Topical; Adult; Antifibrinolytic Agents; Contusions; Double-Blind Method; Face; Humans; Laser Therapy; Lasers; Telangiectasis; Treatment Outcome; Vitamin K

Although there are several reports of intracranial hemorrhage associated with vitamin K deficient bleeding, there are few reported cases of extracranial manifestations, specifically involving the thymus. Here, we discuss the unique case of a 4-week-old infant presenting with scrotal discoloration, respiratory distress, and widened mediastinum, found to have thymic hemorrhage related to confirmed coagulopathy secondary to late-onset vitamin K deficiency bleeding of the newborn.

Topics: Antifibrinolytic Agents; Contusions; Diagnosis, Differential; Genital Diseases, Male; Humans; Infant, Newborn; Male; Mediastinum; Respiratory Distress Syndrome, Newborn; Scrotum; Thymus Gland; Treatment Outcome; Vitamin K; Vitamin K Deficiency; Vitamin K Deficiency Bleeding

Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Blood Coagulation Disorders; Contusions; Epistaxis; Female; Hematemesis; Humans; Male; Middle Aged; Vitamin K; Vitamins; Warfarin

Topics: Bilirubin; Birth Weight; Contusions; Female; Gestational Age; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice, Neonatal; Male; Phototherapy; Respiratory Distress Syndrome, Newborn; Temperature; Vitamin K