vitamin-k-semiquinone-radical and Ascorbic-Acid-Deficiency

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Breast Feeding; Child, Preschool; Cystic Fibrosis; Female; Humans; Hypervitaminosis A; Infant; Infant, Newborn; Male; Rickets; Vitamin A; Vitamin A Deficiency; Vitamin B Complex; Vitamin D; Vitamin E; Vitamin K; Vitamins

Topics: Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid Deficiency; Bacteria; Calcium; Chickens; Disaccharidases; Fatty Acids, Essential; Germ-Free Life; Guinea Pigs; Intestines; Iron; Rabbits; Rats; Vitamin A Deficiency; Vitamin B Complex; Vitamin K

Topics: Adolescent; Adult; Ascorbic Acid Deficiency; Avitaminosis; Calcium; Contraceptives, Oral; Copper; Female; Folic Acid Deficiency; Humans; Iron; Metals; Middle Aged; Nicotinic Acids; Nutritional Requirements; Pregnancy; Riboflavin Deficiency; Vitamin A; Vitamin B 12; Vitamin B 6 Deficiency; Vitamin K; Vitamins; Zinc

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Folic Acid; Folic Acid Deficiency; Humans; Pyridoxine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Deficiency; Vitamin D; Vitamin D Deficiency; Vitamin E; Vitamin E Deficiency; Vitamin K; Vitamin K Deficiency; Vitamins

beta- Hydroxyaspartic acid is a rare amino acid, present in all vitamin K-dependent plasma proteins except prothrombin, and is formed by a post-translational hydroxylation of aspartic acid. We have now investigated whether this hydroxylation, like that of proline in collagen, is vitamin C-dependent. The vitamin K-dependent plasma proteins were isolated from normal and scorbutic guinea pig plasma by barium citrate adsorption and the beta- hydroxyaspartic acid content was determined. Compared with normal animals, scorbutic animals showed no significant reduction of beta- hydroxyaspartic acid content. In warfarin-treated animals there was a decreased content of both beta- hydroxyaspartic acid and gamma-carboxyglutamic acid in the barium citrate adsorbed fraction. It was concluded that the post-translational hydroxylation of aspartic acid is unlikely to be vitamin C-dependent.

Topics: 1-Carboxyglutamic Acid; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Aspartic Acid; Blood Coagulation; Blood Proteins; Guinea Pigs; Hydroxylation; Protein Processing, Post-Translational; Vitamin K; Warfarin

The physiological mechanism to prevent and control abnormal bleeding is dependent on three vitamins (C, K, and Q). Two of these are unequivocally established as essential for hemostasis while the existence of the third (Q) is supported by experimental evidence and by clinical and therapeutic observations (Quick 1972; Quick 1974). The interrelationship of these three vitamins has remained moot except for clue observations. Both vitamins C and K have a key structure in their molecules which supplies a redox mechanism, ascorbic acid and 2-methyl, 1,4-naphthoquinone, respectively. Both vitamins are concerned with growth. Lack of vitamin C, which clinically is the basic defect of scurvy, does not appear to cause a defect in blood coagulation while vitamin K affects the clotting mechanism by being essential for the production of four distinct clotting factors: prothrombin, factors VII, IX and X. In this presentation an attempt is made to correlate the action of the vitamin K-dependent clotting factors grouping them in a diagram to show how two systems of thrombin formation exist, one being essentially intrinsic, the second extrinsic requiring tissue thromboplastin and factor VII. The possible interlocking of vitamin Q in this mechanism is presented.

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Coagulation; Blood Coagulation Factors; Factor VII; Humans; Lampreys; Models, Biological; Oxidation-Reduction; Prothrombin Time; Thromboplastin; Vitamin K; Vitamins

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Coagulation Factors; Blood Platelet Disorders; Blood Platelets; Dicumarol; Factor VII; Glycine max; Hemorrhage; Hemostatics; Humans; Pedigree; Phospholipids; Plasma; Prothrombin; Prothrombin Time; Rabbits; Thrombocytopenia; Thromboplastin; Vitamin K; Vitamin K Deficiency

Topics: Animals; Ascorbic Acid Deficiency; Ergocalciferols; Fatty Acids, Essential; Guinea Pigs; Vitamin A; Vitamin K

Topics: Ascorbic Acid Deficiency; Humans; Hypercalcemia; Nephrocalcinosis; Urinary Calculi; Vitamin A; Vitamin A Deficiency; Vitamin B 6 Deficiency; Vitamin D; Vitamin K; Vitamins

Topics: Animals; Ascorbic Acid Deficiency; Guinea Pigs; Vitamin K

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Coagulation; Folic Acid; Guinea Pigs; Vitamin K; Vitamins

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Biological Phenomena; Capillaries; Capillary Resistance; Guinea Pigs; Physiological Phenomena; Vitamin A; Vitamin K; Vitamins

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Coagulation; Blood Coagulation Tests; Guinea Pigs; Scurvy; Vitamin A; Vitamin D; Vitamin K; Vitamins