vitamin k 3 has been researched along with Pancreatic Neoplasms in 9 studies
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Menadione, which produces H(2)O(2) via redox cycling mechanism in a dose-dependent manner, was investigated for its effect on β-cell metabolism and insulin secretion in INS-1 832/13, a rat β-cell insulinoma cell line, and primary rodent islets." | 3.78 | The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion. ( Gray, JP; Heart, E; Palo, M; Smith, PJ; Womack, T, 2012) |
| "In the human pancreatic cancer cell line MIA PaCa-2, dicumarol decreased cell viability, as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and decreased clonogenic survival." | 1.32 | Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress. ( Cullen, JJ; Hinkhouse, MM; Lewis, A; Li, L; Ough, M; Ritchie, JM; Spitz, DR, 2004) |
| " Mitochondrial catalase overexpression also preferentially protected against the toxicity of interleukin-1beta (IL-1beta) and a proinflammatory cytokine mixture (IL-1beta, tumor necrosis factor-alpha [TNF-alpha], and gamma-interferon [IFN-gamma]) that is more toxic than IL-1beta alone." | 1.32 | Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. ( Gurgul, E; Jörns, A; Lenzen, S; Lortz, S; Tiedge, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sancho, P | 1 |
| Burgos-Ramos, E | 1 |
| Tavera, A | 1 |
| Bou Kheir, T | 1 |
| Jagust, P | 1 |
| Schoenhals, M | 1 |
| Barneda, D | 1 |
| Sellers, K | 1 |
| Campos-Olivas, R | 1 |
| Graña, O | 1 |
| Viera, CR | 1 |
| Yuneva, M | 1 |
| Sainz, B | 1 |
| Heeschen, C | 1 |
| Li, T | 1 |
| Perez-Soler, R | 1 |
| Osada, S | 2 |
| Yoshida, K | 1 |
| Heart, E | 1 |
| Palo, M | 1 |
| Womack, T | 1 |
| Smith, PJ | 1 |
| Gray, JP | 1 |
| Park, SY | 1 |
| Chang, I | 1 |
| Kim, JY | 1 |
| Kang, SW | 1 |
| Park, SH | 1 |
| Singh, K | 1 |
| Lee, MS | 1 |
| Lewis, A | 1 |
| Ough, M | 1 |
| Li, L | 1 |
| Hinkhouse, MM | 1 |
| Ritchie, JM | 1 |
| Spitz, DR | 1 |
| Cullen, JJ | 1 |
| Gurgul, E | 1 |
| Lortz, S | 1 |
| Tiedge, M | 1 |
| Jörns, A | 1 |
| Lenzen, S | 1 |
| Sakashita, F | 1 |
| Hosono, Y | 1 |
| Nonaka, K | 1 |
| Tokuyama, Y | 1 |
| Tanaka, H | 1 |
| Sasaki, Y | 1 |
| Tomita, H | 1 |
| Komori, S | 1 |
| Matsui, S | 1 |
| Takahashi, T | 1 |
| LeDoux, SP | 1 |
| Wilson, GL | 1 |
3 reviews available for vitamin k 3 and Pancreatic Neoplasms
| Article | Year |
|---|---|
Skin toxicities associated with epidermal growth factor receptor inhibitors.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Non-Small-Cell Lung; | 2009 |
A novel strategy for advanced pancreatic cancer - progression of molecular targeting therapy.
Topics: Cell Division; Disease Progression; Drug Delivery Systems; Humans; Pancreatic Neoplasms; Phosphoryla | 2009 |
Base excision repair of mitochondrial DNA damage in mammalian cells.
Topics: Alkylation; Animals; Bleomycin; Caspases; Cerebellar Cortex; CHO Cells; Cricetinae; Cricetulus; DNA | 2001 |
6 other studies available for vitamin k 3 and Pancreatic Neoplasms
| Article | Year |
|---|---|
MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Drug Resistance, Neoplasm; Gene Library | 2015 |
The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion.
Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Glucose; Hydrogen Peroxide; Insulin; In | 2012 |
Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; DNA, Mitochondrial; Doxorubicin; D | 2004 |
Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Cytochromes c; Dicumarol; Do | 2004 |
Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.
Topics: Animals; Antifibrinolytic Agents; Antineoplastic Agents; Catalase; Cell Line, Tumor; Cytokines; Gene | 2004 |
Extracellular signal-regulated kinase phosphorylation due to menadione-induced arylation mediates growth inhibition of pancreas cancer cells.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Extracellu | 2008 |