vitamin k 3 has been researched along with Neoplasms in 19 studies
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among the phenotypical features of cancer cells, two of them are of particular interest: their nearly universal glycolytic phenotype and their sensitivity towards an oxidative stress, both resulting from the combination of high anabolic needs and hypoxic growth conditions." | 2.44 | Targeting cancer cells by an oxidant-based therapy. ( Buc Calderon, P; Taper, H; Verrax, J, 2008) |
| "This investigation reports on the anticancer activity of these VK3 analogues against TK10 renal, UACC62 melanoma, MCF7 breast, HeLa cervical, PC3 prostate and HepG2 liver cancer cell lines to evaluate their cytostatic effects." | 1.56 | Anticancer activities of vitamin K3 analogues. ( Hlatshwayo, V; Kaur, M; Kolesnikova, NI; Motadi, LR; Saha, ST; Wellington, KW, 2020) |
| "Several cancer and normal cell lines of the same origin were used." | 1.56 | Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. ( Aoki, I; Bakalova, R; Higashi, T; Miller, T; Semkova, S; Sugaya, K; Zhelev, Z, 2020) |
| "A bioguided study of cancer cell models led us to a new member of the jatrophane natural products from Jatropha gossypiifolia, which was independently identified and characterized as jatrogossone A (1)." | 1.51 | Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models. ( Bollinger, J; Budhraja, A; Craig, J; Lang, WH; Ling, T; Maier, J; Marsico, TD; Opferman, J; Potts, MB; Rivas, F, 2019) |
| "Many promising anticancer molecules are abandoned during the course from bench to bedside due to lack of clear-cut efficiency and/or severe side effects." | 1.42 | PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. ( Hatem, E; He, T; Huang, ME; Lei, M; Vernis, L, 2015) |
| "We postulate that cancer cells are more sensitive to asc/men than healthy cells because of their lack of antioxidant enzymes, mainly catalase." | 1.37 | Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study. ( Beck, R; Calderon, PB; Dejeans, N; Eeckhoudt, S; Gallez, B; Glorieux, C; Knoops, L; Levêque, P; Pedrosa, RC; Taper, H; Verrax, J, 2011) |
| "Many cancers are deficient in catalase activity, and maintain a moderate level of oxidative stress to aid their proliferation and survival." | 1.36 | Oxidative stress therapy for solid tumors - a proposal. ( Barroso-Aranda, J; Contreras, F; McCarty, MF, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 6 (31.58) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 2 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 2 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 2 |
| Ling, T | 1 |
| Lang, WH | 1 |
| Craig, J | 1 |
| Potts, MB | 1 |
| Budhraja, A | 1 |
| Opferman, J | 1 |
| Bollinger, J | 1 |
| Maier, J | 1 |
| Marsico, TD | 1 |
| Rivas, F | 1 |
| Liang, B | 1 |
| Zhou, D | 1 |
| Gul, S | 1 |
| Maqbool, MF | 1 |
| Maryam, A | 1 |
| Khan, M | 1 |
| Shakir, HA | 1 |
| Irfan, M | 1 |
| Ara, C | 1 |
| Ma, T | 1 |
| Ke, Q | 1 |
| Jing, P | 1 |
| Wan, Y | 1 |
| Xia, T | 1 |
| Cao, X | 1 |
| Jiang, K | 1 |
| Wellington, KW | 1 |
| Hlatshwayo, V | 1 |
| Kolesnikova, NI | 1 |
| Saha, ST | 1 |
| Kaur, M | 1 |
| Motadi, LR | 1 |
| Kizhuveetil, U | 1 |
| Omer, S | 1 |
| Karunagaran, D | 1 |
| Suraishkumar, GK | 1 |
| Semkova, S | 1 |
| Zhelev, Z | 1 |
| Miller, T | 1 |
| Sugaya, K | 1 |
| Aoki, I | 1 |
| Higashi, T | 1 |
| Bakalova, R | 1 |
| He, T | 1 |
| Hatem, E | 1 |
| Vernis, L | 1 |
| Lei, M | 1 |
| Huang, ME | 1 |
| Verrax, J | 3 |
| Taper, H | 2 |
| Buc Calderon, P | 2 |
| McCarty, MF | 1 |
| Barroso-Aranda, J | 1 |
| Contreras, F | 1 |
| Beck, R | 1 |
| Pedrosa, RC | 1 |
| Dejeans, N | 1 |
| Glorieux, C | 1 |
| Levêque, P | 1 |
| Gallez, B | 1 |
| Eeckhoudt, S | 1 |
| Knoops, L | 1 |
| Calderon, PB | 2 |
| Anupriya, G | 1 |
| Roopa, K | 1 |
| Basappa, S | 1 |
| Chong, YS | 1 |
| Annamalai, L | 1 |
| Jiang, Z | 1 |
| Wang, B | 1 |
| Wang, Y | 1 |
| Hu, X | 1 |
| Cadrobbi, J | 2 |
| Marques, C | 1 |
| Hong-Ngoc, N | 1 |
| Jamison, JM | 2 |
| Gilloteaux, J | 2 |
| Summers, JL | 2 |
| Taper, HS | 2 |
| Delvaux, M | 1 |
| Lamson, DW | 1 |
| Plaza, SM | 1 |
| Ogawa, M | 1 |
| Nakai, S | 1 |
| Deguchi, A | 1 |
| Nonomura, T | 1 |
| Masaki, T | 1 |
| Uchida, N | 1 |
| Yoshiji, H | 1 |
| Kuriyama, S | 1 |
| Sasaki, R | 1 |
| Suzuki, Y | 1 |
| Yonezawa, Y | 1 |
| Ota, Y | 1 |
| Okamoto, Y | 1 |
| Demizu, Y | 1 |
| Huang, P | 1 |
| Yoshida, H | 1 |
| Sugimura, K | 1 |
| Mizushina, Y | 1 |
6 reviews available for vitamin k 3 and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Vitamin K: A novel cancer chemosensitizer.
Topics: Antineoplastic Agents; Humans; Neoplasms; Vitamin K; Vitamin K 1; Vitamin K 2; Vitamin K 3 | 2022 |
Targeting cancer cells by an oxidant-based therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Ascorbic Acid; Humans; Neoplasms | 2008 |
Potential therapeutic application of the association of vitamins C and K3 in cancer treatment.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Death; Chemotherapy, Adjuvant; Drug Synergism; Mice; Neop | 2002 |
The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Cell Death; Chemotherapy, Adjuvant; D | 2003 |
The anticancer effects of vitamin K.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle; Humans; Mice; Neoplasms; Rats; Transcription Factors; | 2003 |
13 other studies available for vitamin k 3 and Neoplasms
| Article | Year |
|---|---|
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Cycle Checkpoints; Cell Line, | 2019 |
ROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Respon | 2021 |
Sulfonated vitamin K3 mediated bimetallic metal-organic framework for multistage augmented cancer therapy.
Topics: Alkanesulfonates; Cell Line, Tumor; Humans; Hydrogen Peroxide; Metal-Organic Frameworks; Nanoparticl | 2024 |
Anticancer activities of vitamin K3 analogues.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line; Cell Surviva | 2020 |
Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation.
Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Curcumin; HCT116 Cells; Humans; Hydroxyl Radi | 2020 |
Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Ascorbic Acid; Cell Line, T | 2020 |
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug.
Topics: Antineoplastic Agents; Dactinomycin; Daunorubicin; Doxorubicin; Fluorouracil; Gene Knockdown Techniq | 2015 |
Oxidative stress therapy for solid tumors - a proposal.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Glucose; Humans; Hypoxia-Inducible Factor 1; Models, | 2010 |
Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study.
Topics: Animals; Ascorbic Acid; Cell Death; Cell Line, Tumor; Cytoprotection; Erythrocytes; Fusion Proteins, | 2011 |
Homology modeling and in silico screening of inhibitors for the substrate binding domain of human Siah2: implications for hypoxia-induced cancers.
Topics: Binding Sites; Drug Design; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Hydrogen Bo | 2011 |
Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2.
Topics: Antineoplastic Agents; Carrier Proteins; Cell Line, Tumor; Glucose; HeLa Cells; Humans; Lactic Acid; | 2012 |
Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Rel | 2007 |
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells.
Topics: Antineoplastic Agents; Cell Survival; DNA Polymerase gamma; DNA Repair; DNA-Directed DNA Polymerase; | 2008 |