vitamin-k-1 and Ulcer

vitamin-k-1 has been researched along with Ulcer* in 1 studies

Other Studies

1 other study(ies) available for vitamin-k-1 and Ulcer

ArticleYear
Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1.
    Clinical and experimental pharmacology & physiology, 2023, Volume: 50, Issue:5

    Gastric ulcer is the most common gastrointestinal disorder affecting people globally. Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects. In this study, the potential therapeutic effects of phylloquinone were tested against indomethacin-induced gastric ulcer in rats by giving rats a single oral dose of indomethacin (48 mg/kg), followed by phylloquinone (10 mg/kg) orally, once daily for six consecutive days. Phylloquinone significantly attenuated indomethacin-induced oxidative and inflammatory responses through hindering the inflammatory cascade by decreasing the levels of TNF-α, NF-κB, INOS and COX-2 which counteracts indomethacin effects. Also, it increased NAD

    Topics: Animals; Indomethacin; Rats; Stomach Ulcer; Tumor Necrosis Factor-alpha; Ulcer; Vitamin K 1

2023