vitamin-k-1 and Gallbladder-Neoplasms

Developing an optimal anticoagulant strategy poses a challenging task in patients with mechanical heart valves (MHVs) throughout their lifetime. We report an optimal anticoagulant therapy in a cancer patient with hepatic metastases after MHV replacement.. A 68-year-old female with MHVs suffered from gallbladder cancer with hepatic metastases. Her international normalized ratio (INR) fluctuated owing to the declined hepatic function.. Gallbladder cancer and hepatic metastases, with a history of mechanic aortic valve replacement and mitral valve replacement.. Warfarin was discontinued and Vitamin K1 was immediately administrated via intravenous infusion. low-molecular-weight heparin (LMWH) was regarded as a preferable option, and nadroparin at the dosage of 4100IU daily was administered.. No adverse event occurred during the patient's hospitalization and two-week follow up after discharge.. LMWH may represent a reasonable alternative regarding the inhibition of thrombus and bleeding in MHVs carriers with cancer and hepatic metastases.

Topics: Aged; Anticoagulants; Aortic Valve; Female; Gallbladder Neoplasms; Heart Valve Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heparin, Low-Molecular-Weight; Humans; International Normalized Ratio; Liver Neoplasms; Mitral Valve; Postoperative Complications; Thrombosis; Vitamin K 1