vitamin-d-2 and alpha-1-Antitrypsin-Deficiency

Oral high-dose repletion vitamin D therapy, also known as stoss therapy, can be effective in the treatment of nutritional vitamin D deficiency rickets in infants and young children without liver disease and in patients with cystic fibrosis. There is no literature about this approach in infants with new-onset cholestasis.. This was a retrospective chart review of infants with cholestasis from March 2010 to March 2012 at a pediatric tertiary care center. Four cases satisfied the inclusion criteria, and were described in detail.. All of the patients received oral high-dose repletion therapy with ergocalciferol (vitamin D2) 300,000 IU daily for 2 to 3 days. Follow-up vitamin D levels approximately 4 weeks later showed failure to achieve sufficiency levels (>20 ng/dL) in any patient.. Unlike infants without liver disease, use of oral high-dose repletion therapy may not be adequate as treatment of vitamin D deficiency in the setting of cholestasis.

Topics: Administration, Oral; alpha 1-Antitrypsin Deficiency; Biliary Atresia; Cholestasis; Ergocalciferols; Female; Humans; Infant; Male; Retrospective Studies; Tertiary Care Centers; Treatment Failure; Vitamin D; Vitamin D Deficiency