vitamin-d-2 and Psoriasis

Drug-induced hypercalcemia is caused by increased bone resorption (vitamin D and vitamin A intoxication), increased calcium absorption in the gastrointestinal tract (vitamin D intoxication, excessive intake of calcium) or increased calcium reabsorption in the renal tubules (thiazide diuretics). When vitamin D (D(2) or D(3)) intoxication develops, the hypercalcemia persists for more than several months. Therefore, short-acting active vitamin D (1alpha-OHD(3), 1,25- (OH) (2)D(3)) are clinically used. Recently, various analogs of 1,25- (OH) (2)D(3) with potent differentiation stimulating activity on keratinocytes but insufficient calcium-movilizing activity have been developed (tacalcitol, calcipotriol, 22-oxacalcitriol). However, severe hypercalcemia may develop when these ointments were abundantly applied to patients with psoriasis since the agents can be easily absorbed through the skin lesions.

Topics: Bone Resorption; Ergocalciferols; Humans; Hypercalcemia; Psoriasis; Steroid Hydroxylases; Vitamin D

There continues to be a need to develop new pharmacological approaches for treating psoriasis. Topical active vitamin D compounds have proven to be both safe and effective for treating psoriasis. Paricalcitol (19-nor-1 alpha,25-dihydroxyvitamin D(2)) is a novel vitamin D analogue which has been developed for the prevention of secondary hyperparathyroidism in patients with chronic renal failure.. To investigate the efficacy and safety of 12 weeks' therapy with a once-daily application of paricalcitol ointment (15 microg g(-1)) in comparison with placebo ointment.. This pilot double-blinded self-controlled study was initiated in 11 patients with moderate plaque psoriasis. To characterize the biological effects further and to evaluate the efficacy of topical paricalcitol treatment in psoriasis, we have analysed immunohistochemically the expression of one of the markers for epidermal differentiation (transglutaminase K) in paricalcitol-treated skin as compared with placebo treatment.. Treatment with paricalcitol was superior to placebo treatment beginning at week 1. The global severity score for erythema, plaque elevation and scaling was improved significantly more by paricalcitol ointment than by placebo (P < 0.001). Similar results were obtained for assessments of scaling, erythema and plaque elevation. No symptoms of local skin irritation were noted. Laboratory parameters including serum calcium, phosphorus, parathyroid hormone and urinary calcium/creatinine ratio did not reveal any changes of clinical relevance during treatment. The immunoreactivity of transglutaminase K changed after 12 weeks of paricalcitol treatment almost completely to the pattern characteristic for nonlesional psoriatic skin.. Once-daily application of paricalcitol ointment was safe and effective for the treatment of plaque psoriasis.

Topics: Administration, Topical; Adult; Aged; Biomarkers; Cell Division; Double-Blind Method; Ergocalciferols; Humans; Immunosuppressive Agents; Middle Aged; Pilot Projects; Psoriasis; Skin; Transglutaminases

Vitamin D has important immunomodulatory effects on psoriasis in the Mediterranean region. To measure vitamin D intake in subjects with and without psoriasis, and to find an association with relevant clinical features, a case-control study was performed using cases (n = 50, 50% participation rate) clinically diagnosed with psoriasis and 200 healthy subjects (39.5% participation rate), leaving a final sample of 104 people. A survey was conducted using a food frequency questionnaire and clinical histories. Cases and controls were compared using univariate and multivariate analyses. We observed insufficient intake of cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) for both cases and controls. Patients with psoriasis were at greater risk of associated pathologies: dyslipidaemia (OR: 3.6, 95% CI: 0.8-15.2); metabolic syndrome (OR: 3.3, 95% CI: 0.2-53.9); hypertension (OR: 1.7, 95% CI: 0.4-7.2). Insufficient vitamin D intake in both psoriasis patients and controls in the Mediterranean population, and cardiovascular comorbility is more frequent in patients with psoriasis.

Topics: Adult; Case-Control Studies; Cholecalciferol; Ergocalciferols; Female; Humans; Male; Middle Aged; Odds Ratio; Psoriasis; Spain; Vitamin D Deficiency; Young Adult

Topics: Aged; Calcium; Drug Therapy, Combination; Ergocalciferols; Humans; Hypocalcemia; Hypoparathyroidism; Male; Psoriasis

A 26-year-old pregnant woman was hospitalized in an emergency setting for a skin eruption. She had developed pustules distributed on round patch-like areas of rash localized at the umbilicus and the larger skin folds. She was given calcitriol and calcium with good results. Systemic steroids are usually given for exanthematic pustulosis of pregnancy but with variable efficacy. Few cases of successful treatment with calcium and vitamin D have been reported. We suggest this alternative treatment could be useful in other cases.

Topics: Adult; Calcium; Ergocalciferols; Female; Humans; Pregnancy; Pregnancy Complications; Psoriasis; Treatment Outcome

Topics: Adrenal Cortex Hormones; Anthraquinones; Betamethasone; Coal Tar; Ergocalciferols; Humans; Mercury; Ointments; ortho-Aminobenzoates; Psoriasis; Salicylates; Sulfur; Triamcinolone

Topics: Calcium; Calcium, Dietary; Drug Therapy; Ergocalciferols; Humans; Hypocalcemia; Postoperative Complications; Psoriasis; Thyroidectomy

Topics: Data Collection; Drug Therapy; Ergocalciferols; Folic Acid; Humans; Lactates; Lactic Acid; Psoriasis

Topics: Ergocalciferols; Humans; Hypocalcemia; Hypoparathyroidism; Iatrogenic Disease; Postoperative Complications; Psoriasis; Tetany; Thyroidectomy

Topics: Cholestanes; Ergocalciferols; Humans; Psoriasis; Vitamin D; Vitamins

Topics: Ergocalciferols; Exanthema; Humans; Penicillins; Psoriasis; Skin Diseases, Vesiculobullous; Vitamin D; Vitamins

Topics: Cholestanes; Ergocalciferols; Humans; Psoriasis; Vitamin D; Vitamins

Topics: Cholestanes; Ergocalciferols; Humans; Psoriasis; Vitamin D; Vitamins

Topics: Cholestanes; Ergocalciferols; Humans; Psoriasis; Vitamin D; Vitamins