vitamin-d-2 and Infant--Newborn--Diseases

Topics: Adult; Age Factors; Anemia, Pernicious; Calcium; Candidiasis; Child; Dihydrotachysterol; Endocrine System Diseases; Ergocalciferols; Humans; Hypoparathyroidism; Infant, Newborn; Infant, Newborn, Diseases

The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the dihydroxylated metabolites of vitamin D were found to be normal and a pronounced increase was noted 24 hours after injection of 100 000 IU vitamin D2. The study suggests that during the neonatal period a small renal mass is sufficient to maintain optimal circulating levels of the dihydroxylated metabolites of vitamin D.

Topics: Dihydroxycholecalciferols; Ergocalciferols; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kidney; Kidney Failure, Chronic; Male

Topics: 25-Hydroxyvitamin D 2; Ergocalciferols; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Newborn, Diseases; Rickets

Topics: Drug Combinations; Ergocalciferols; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital

Using the Haddad modified method, 25-OH-D were measured in the blood of the umbilical cord of 29 infants and in peripheral serum after 6 weeks. 16 infants were given a daily dosage of 1000 I. E., 13 infants 500 I. E. vitamin D against rickets. Further they were fed with an adapted milk containing 400 I. E. vitamin D/1. The mean cord serum values were 13 and 15 ng/ml. After treatment with 1000 I. E., 25-OH-D values around 54 ng/ml were measured after 6 weeks and under 500 I. E. daily, values of 37 ng/ml, respectively. Treatment using a dosage of 500 I. E. vitamin D combined with feeding with vitamin D fortified milk seems adequate, to prevent vitamin D depletion.

Topics: 25-Hydroxyvitamin D 2; Cholecalciferol; Dose-Response Relationship, Drug; Ergocalciferols; Humans; Infant, Newborn; Infant, Newborn, Diseases; Rickets; Vitamin D Deficiency

Rickets is now a well-known entity in infants of very low birthweight. In a 1-year period (1981) 8 of 15 neonatal survivors whose birthweight was less than 1000 g (extremely low birthweight) developed rickets despite high supplementation with ergo-calciferol, 2000 units a day. At the time of radiological diagnosis their postnatal age was 8 (range 5-14) weeks, and they all had normal or high plasma concentrations of 25-hydroxyvitamin D (mean 80 nmol/l, range 40-160 nmol/l). Although 4 infants received alfacalcidol which healed the rickets, in 4 infants the rickets healed spontaneously without change in treatment. The results suggest that inadequate vitamin D supplementation is not the cause of rickets in such infants.

Topics: 25-Hydroxyvitamin D 2; Alkaline Phosphatase; Calcium; Ergocalciferols; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Newborn, Diseases; Phosphorus; Rickets

Topics: Adenoma; Adult; Alkaline Phosphatase; Calcium; Cardiomegaly; Cardiomyopathies; Ergocalciferols; Female; Humans; Hyperparathyroidism; Hypocalcemia; Hypoparathyroidism; Infant, Newborn; Infant, Newborn, Diseases; Parathyroid Hormone; Parathyroid Neoplasms; Perfusion; Phosphorus; Pregnancy; Pregnancy Complications

Topics: Adult; Alkaline Phosphatase; Calcium; Emigration and Immigration; Ergocalciferols; Ethnicity; Female; Humans; India; Infant, Newborn; Infant, Newborn, Diseases; Male; Pakistan; Phosphorus; Rickets; Scotland

Topics: Adenosine Triphosphate; Caseins; Ergocalciferols; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Rickets

Topics: Abortion, Spontaneous; Anemia, Hemolytic, Congenital; Animals; Ascorbic Acid; Ergocalciferols; Female; Humans; Hydrocephalus; Infant, Newborn; Infant, Newborn, Diseases; Jaundice, Neonatal; Maternal-Fetal Exchange; Osteomalacia; Pregnancy; Pregnancy, Prolonged; Pyridoxine; Rats; Scurvy; Seizures; Skull; Vitamin A; Vitamin B 12; Vitamin E; Vitamin K; Vitamins

Topics: Calcium; Child; Dihydrotachysterol; Electrocardiography; Electromyography; Ergocalciferols; Female; Humans; Hypoparathyroidism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Seizures; Tetany

Topics: Alkaline Phosphatase; Blood; Bone and Bones; Calcium; Calcium, Dietary; Diagnosis, Differential; Ergocalciferols; Humans; Hypercalcemia; Hyperparathyroidism; Hyperparathyroidism, Primary; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intellectual Disability; Pathology; Phosphorus; Radiography; Rickets