vitamin-d-2 and Hyperplasia

vitamin-d-2 has been researched along with Hyperplasia* in 2 studies

Other Studies

2 other study(ies) available for vitamin-d-2 and Hyperplasia

Article	Year
p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium. Kidney international, 2001, Volume: 60, Issue:6 High dietary phosphorus (P) worsens uremia-induced parathyroid (PT) hyperplasia through increases in the growth promoter transforming growth factor-alpha (TGF-alpha). In contrast, P restriction prevents PT hyperplasia by inducing the cell cycle inhibitor p21. Since 1,25(OH)2D3-antiproliferative action in various cell types involve increases in p21, we studied whether induction of p21 by 1,25(OH)2D3 or the vitamin D analog, 19-Nor-1,25(OH)2D2, could counteract the PT hyperplasia induced by high dietary P in early uremia.. Normal (N) and uremic (U; 5/6 nephrectomized) female Sprague-Dawley rats were fed high P (HP), low P (LP) or high Ca (HCa) diets and administered intraperitoneally (IP) either vehicle or vitamin D metabolites for seven days, as follows: N-HP; U-HP + vehicle; U-HP + 1,25(OH)2D3 (4 ng/day); U-HP + 19-Nor-1,25(OH)2D2 (30 ng/day); U-LP; U-HCa. Serum PTH and PT gland weight assessed secondary hyperparathyroidism. Immunohistochemical quantitation of two markers of mitotic activity, Ki67 and PCNA measured PT hyperplasia. Immunohistochemical expression of PT p21 and TGF-alpha addressed potential mechanisms regulating PT cell growth.. 1,25(OH)2D3 and 19-Nor-1,25(OH)2D2 were effective in suppressing both PTH secretion and PT hyperplasia induced by uremia and high dietary P independent of increases in ionized Ca. Both vitamin D compounds enhanced PT p21 expression and prevented high P-induced increases in PT TGF-alpha content. Induction of PT p21 and reduction of TGF-alpha content also occurred when uremia-induced PT hyperplasia was suppressed by high dietary Ca.. In early uremia, vitamin D suppression of high P-induced PT hyperplasia and high dietary Ca arrest of PT growth involve induction of PT p21 and prevention of increases in TGF-alpha. Topics: Animals; Blood; Calcium, Dietary; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Ergocalciferols; Female; Hyperplasia; Parathyroid Glands; Parathyroid Hormone; Phosphorus, Dietary; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha; Uremia; Vitamin D	2001
The ultimobranchial body in Rana pipiens. IV. Hypercalcemia and glandular hypertrophy. Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948), 1968, Volume: 85, Issue:4 Topics: Animals; Anura; Branchial Region; Calcium; Endocrine Glands; Ergocalciferols; Hypercalcemia; Hyperplasia; Hypertrophy; Male; Seasons	1968

Article

Year

p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium.

Kidney international, 2001, Volume: 60, Issue:6

High dietary phosphorus (P) worsens uremia-induced parathyroid (PT) hyperplasia through increases in the growth promoter transforming growth factor-alpha (TGF-alpha). In contrast, P restriction prevents PT hyperplasia by inducing the cell cycle inhibitor p21. Since 1,25(OH)2D3-antiproliferative action in various cell types involve increases in p21, we studied whether induction of p21 by 1,25(OH)2D3 or the vitamin D analog, 19-Nor-1,25(OH)2D2, could counteract the PT hyperplasia induced by high dietary P in early uremia.. Normal (N) and uremic (U; 5/6 nephrectomized) female Sprague-Dawley rats were fed high P (HP), low P (LP) or high Ca (HCa) diets and administered intraperitoneally (IP) either vehicle or vitamin D metabolites for seven days, as follows: N-HP; U-HP + vehicle; U-HP + 1,25(OH)2D3 (4 ng/day); U-HP + 19-Nor-1,25(OH)2D2 (30 ng/day); U-LP; U-HCa. Serum PTH and PT gland weight assessed secondary hyperparathyroidism. Immunohistochemical quantitation of two markers of mitotic activity, Ki67 and PCNA measured PT hyperplasia. Immunohistochemical expression of PT p21 and TGF-alpha addressed potential mechanisms regulating PT cell growth.. 1,25(OH)2D3 and 19-Nor-1,25(OH)2D2 were effective in suppressing both PTH secretion and PT hyperplasia induced by uremia and high dietary P independent of increases in ionized Ca. Both vitamin D compounds enhanced PT p21 expression and prevented high P-induced increases in PT TGF-alpha content. Induction of PT p21 and reduction of TGF-alpha content also occurred when uremia-induced PT hyperplasia was suppressed by high dietary Ca.. In early uremia, vitamin D suppression of high P-induced PT hyperplasia and high dietary Ca arrest of PT growth involve induction of PT p21 and prevention of increases in TGF-alpha.

Topics: Animals; Blood; Calcium, Dietary; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Ergocalciferols; Female; Hyperplasia; Parathyroid Glands; Parathyroid Hormone; Phosphorus, Dietary; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha; Uremia; Vitamin D

2001

The ultimobranchial body in Rana pipiens. IV. Hypercalcemia and glandular hypertrophy.

Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948), 1968, Volume: 85, Issue:4

Topics: Animals; Anura; Branchial Region; Calcium; Endocrine Glands; Ergocalciferols; Hypercalcemia; Hyperplasia; Hypertrophy; Male; Seasons

1968