vitamin-b-12 and Uterine-Neoplasms

Although GnRH analogues are widely used to treat a variety of sex hormone-related diseases, little is known about their effect on metabolism. Therefore, we have evaluated the effect of a GnRH analogue, administered with or without raloxifene, on serum levels of lipoproteins, glucose, insulin and homocysteine (Hcy).. One hundred premenopausal women with symptomatic uterine leiomyomas were initially enrolled and randomized to receive 3.75 mg/28 days leuprolide acetate depot associated with 60 mg/day raloxifene hydrochloride (group A) or 1 placebo tablet/day (group B) for six cycles of 28 days. At entry and at cycle 6, subjects underwent anthropometric measurements, including body mass index and waist-to-hip ratio measurements, and blood chemistry assays for serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, Hcy, vitamin B(12) and folate concentrations. Insulin resistance was evaluated with the homeostasis model assessment (HOMA) score.. Baseline parameters were similar in the two groups. At cycle 6, TC, HDL-C, LDL-C and TG levels were significantly increased (P < 0.05) in group B. In group A, LDL-C levels were unchanged, and TC, HDL-C and TG levels were increased (P < 0.05). Serum TC and LDL-C levels differed (P < 0.05) between the groups. Glucose levels were unchanged between and within groups, whereas insulin levels and HOMA scores increased (P < 0.05) versus baseline in group B. Post-treatment Hcy levels were higher (P < 0.05) versus baseline in group B; they were unchanged in group A. Serum vitamin B(12) and folate concentrations were unchanged in both groups.. GnRH analogues alter serum lipoprotein and Hcy levels and increase insulin resistance. These acute metabolic changes may be prevented or reduced by raloxifene.

Topics: Adult; Blood Glucose; Body Constitution; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Delayed-Action Preparations; Female; Folic Acid; Homeostasis; Homocysteine; Humans; Insulin; Insulin Resistance; Leiomyoma; Leuprolide; Lipids; Middle Aged; Placebos; Premenopause; Raloxifene Hydrochloride; Triglycerides; Uterine Neoplasms; Vitamin B 12

To investigate the association of mole hydatidiform with plasma homocysteine, vitamin B(12), and folate levels.. Sixty-eight patients diagnosed with mole hydatidiform at our clinic between February and October 2007 were assessed in a case-control study. Plasma homocysteine, vitamin B12, and folate levels, taken before evacuation of patients with hydatidiform mole, were compared with the results of 100 healthy normal pregnants of first trimester; and also plasma homocysteine, vitamin B12, and folate levels were compared according to histopathological types of mole hydatidiforms. SPSS 14.0 package program was used to analyze the data. Logarithmic transformation was applied for variables. Parameters were expressed as mean+/-standard deviation.. The mean of plasma homocysteine levels was higher in molar group (0.8+/-0.13) than in normal pregnant group (0.7+/-0.13) and the difference was statistically significant (P<0.001). The mean of plasma vitamin B12 levels was found to be similar both in normal pregnant women (2.4+/-0.17) and in the molars (2.4+/-0.15) (P=0.272). The mean of plasma folate levels was lower in molar group (1.0+/-0.15) than in normal pregnant women (1.2+/-0.17) and the difference was statistically significant (P<0.001). The hydatidiform moles of 68 patients were divided into two groups according to histopathological examination: 36 patients were partial moles and the others were complete. The difference of plasma mean homocysteine, vitamin B12, and folate levels in these two groups was not statistically significant. There were statistically significant differences of plasma mean homocysteine and folate levels one by one in complete and in partial moles when compared with the normal pregnants. The mean of plasma folate levels were lower (1.0+/-0.17 for partials, 1.0+/-0.13 for completes) and the homocysteine levels were higher (0.9+/-0.14 for partials, 0.8+/-0.12 for completes) than the levels of normal group.. This study suggests that there may be an association between plasma folate and homocysteine levels with hydatidiform moles. Folate may play a protective role in preventing molar pregnancy. Further controlled prospective studies are needed to investigate the possible effect of homocysteine, vitamin B12, and folate in molar pregnancies.

Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hydatidiform Mole; Pregnancy; Statistics, Nonparametric; Uterine Neoplasms; Vitamin B 12

A novel mechanistic hypothesis is proposed which suggests that hyperhomocysteinemia is a risk factor for the development of estrogen-induced hormonal cancer in humans. Mechanistically, hyperhomocysteinemia may exert its pathogenic effects largely through metabolic accumulation of intracellular S-adenosyl-L-homocysteine, a strong non-competitive inhibitor of the catechol-O-methyltransferase-mediated methylation metabolism of endogenous and exogenous catechol estrogens (mainly 2-hydroxyestradiol and 4-hydroxyestradiol). While a strong inhibition of the methylation metabolism of 2-hydroxyestradiol would decrease the formation of 2-methoxyestradiol (an antitumorigenic endogenous metabolite of 17beta-estradiol), an inhibition of the methylation of 4-hydroxyestradiol would lead to accumulation of this hormonally-active and strongly procarcinogenic catechol estrogen metabolite. Both of these effects resulting from inhibition of the methylation metabolism of catechol estrogens would facilitate the development of estrogen-induced hormonal cancer in the target organs. This hypothesis also predicts that adequate dietary intake of folate, vitamin B6, and vitamin B12 may reduce hyperhomocysteinemia-associated risk for hormonal cancer. Experimental studies are warranted to determine the relations of hyperhomocysteinemia with the altered circulating or tissue levels of 4-hydroxyestradiol and 2-methoxyestradiol and also with the altered risk for estrogen-induced hormonal cancer.

Topics: Anticarcinogenic Agents; Breast Neoplasms; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Estradiol; Estrogens; Estrogens, Catechol; Female; Folic Acid; Humans; Hyperhomocysteinemia; Kinetics; Methylation; Models, Biological; Mutagenicity Tests; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Risk Factors; S-Adenosylhomocysteine; Uterine Neoplasms; Vitamin B 12; Vitamin B 6

The influence of external abdominal irradiation and cytostatic therapy on the vitamin status was studied in patients with cancer of the uterus, bladder or prostate and in patients with malignant lymphoma. It was found that the vitamin status of these patients at the beginning of therapy in general was adequate, though vitamin A and vitamin D levels were reduced. During radiotherapy decreases of vitamin E, vitamin C, vitamin B12 and folic acid levels were observed. Chemotherapy caused a decrease of the folic acid levels after a few months. No clinical symptoms of vitamin deficiency were observed.

Topics: Ascorbic Acid; Calcifediol; Female; Humans; Lymphoma; Male; Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Vitamin A; Vitamin B 12; Vitamin E; Vitamins

Topics: Adult; Aged; Cobalt Radioisotopes; Female; Humans; Intestinal Absorption; Iron; Iron Radioisotopes; Malabsorption Syndromes; Middle Aged; Radiation Injuries; Radionuclide Imaging; Radiotherapy Dosage; Uterine Neoplasms; Vitamin B 12

Topics: Adult; Aged; Female; Humans; Intestinal Absorption; Intestine, Small; Middle Aged; Uterine Neoplasms; Vitamin B 12; Xylose

Topics: Adult; Aged; Female; Humans; Intestinal Absorption; Middle Aged; Radiotherapy; Uterine Cervical Neoplasms; Uterine Neoplasms; Vitamin B 12; Xylose

Topics: Aged; Arteries; Calcium; Cobalt Isotopes; Colon; Colon, Sigmoid; Enterocolitis, Pseudomembranous; Feces; Female; Folic Acid; Hodgkin Disease; Humans; Intestine, Large; Intestine, Small; Iron; Lipids; Male; Middle Aged; Mucous Membrane; Radiography; Radioisotope Teletherapy; Rectal Diseases; Rectum; Serum Albumin; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Vitamin B 12; Xylose

Topics: Androstanes; Androstenols; Ascorbic Acid; Cobalt Isotopes; Convalescence; Cystine; Drug Synergism; Female; Genital Neoplasms, Female; Humans; Ovarian Neoplasms; Pantothenic Acid; Pyridoxine; Radioisotope Teletherapy; Thiamine; Uterine Cervical Neoplasms; Uterine Neoplasms; Vitamin A; Vitamin B 12; Vitamin B Complex

Topics: Corrinoids; Female; Hematinics; Humans; Radiation Injuries; Radiotherapy; Radium; Uterine Neoplasms; Vitamin B 12; X-Rays

Topics: Androgens; Corrinoids; Female; Hematinics; Humans; Testosterone; Uterine Neoplasms; Vitamin B 12