vitamin-b-12 and Urticaria

Topics: Administration, Oral; Aged; Drug Eruptions; Flushing; Food Hypersensitivity; Humans; Infant; Injections, Intramuscular; Male; Nausea; Urticaria; Vitamin B 12; Vitamin B 12 Deficiency; Yeast, Dried

Lower serum vitamin B12 concentrations have been observed in patients with chronic spontaneous urticaria (CSU). It is known that vitamin B12 deficiency is closely related to hyperhomocysteinaemia, which is associated with a proinflammatory state.. To assess the relationship between vitamin B12 status and concentrations of homocysteine (Hcy) with acute phase response in patients with CSU.. Circulating concentrations of vitamin B12, Hcy and C-reactive protein (CRP) were measured in 42 patients with CSU of varying severity, and compared with 19 healthy controls (HCs).. Significantly lower concentrations of vitamin B12 and higher concentrations of CRP were observed in the serum of the patients with CSU compared with HCs (P < 0.01 and P < 0.001, respectively). However, there were no significant differences in plasma Hcy concentrations between the investigated groups. In addition, no correlations were found between the concentrations of vitamin B12, Hcy and CRP.. Lower values of vitamin B12 concentration in patients with CSU were not associated with higher Hcy concentrations, suggesting that such patients do not have functional vitamin B12 deficiency.

Topics: Adult; Atherosclerosis; Biomarkers; C-Reactive Protein; Chronic Disease; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Immunoturbidimetry; Luminescent Measurements; Male; Severity of Illness Index; Time Factors; Urticaria; Vitamin B 12

Previous reports have suggested a possible role for vitamin D in the etiology of chronic spontaneous urticaria (CSU); however, little information is available regarding the role of other micronutrients. We, therefore, analyzed vitamin D, vitamin B12, and ferritin levels in CSU patients (n = 282) from a preexisting database at Southampton General Hospital. Data were compared against mean micronutrient levels of the general population of the UK, obtained from the National Diet and Nutrition Survey. Vitamin D levels of CSU patients were found to be higher than those of the general UK population (P = 0.001). B12 levels were lower in patients with CSU (P < 0.001) than in the general population. Ferritin levels were found to be lower in male CSU patients than in the general male population (P = 0.009). This association between low B12 and iron levels and CSU might indicate a causal link, with micronutrient replacement as a potential therapeutic option.

Topics: Adult; Biomarkers; Female; Ferritins; Humans; Male; Micronutrients; Middle Aged; Prevalence; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Statistics as Topic; United Kingdom; Urticaria; Vitamin B 12; Vitamin D; Young Adult

Recent studies suggest that autoimmune mechanisms may be involved in the etiology of chronic idiopathic urticaria (CIU). There is a higher prevalence of B12 deficiency in autoimmune diseases and possibly in gastric Helicobacter pylori (H. pylori) infection. The frequency of B12 deficiency in CIU is unknown. Our objective in this study was to determine the prevalence of B12 deficiency in patients with CIU and also its relationship to gastric H. pylori infection and serologic markers of autoimmunity in these groups. Thirty-three patients with CIU and 27 healthy controls were included in the study. Serum vitamin B12 levels, H. pylori infection and serological markers of autoimmunity (anti-thyroglobulin, thyroid microsomal, gastric parietal cell and antinuclear autoantibodies) were investigated. H. pylori infection was determined according to serology and gastric biopsy in 19 patients, serology and urea breath test in 4 patients and serology alone in the remaining 10 patients. Serum B12 levels were below the normal reference range in 11/33 (33.3%) patients with CIU. The mean serum B12 levels among patients with CIU and the controls were 281+/-127.5 pg/ml and 465.1+/-140.3 pg/ml (p=0.0001), respectively. Anti-thyroid antibodies were positive in 6 of 11 patients (54.5%) with low B12 levels, but only in 4 of 27 (14.8%) healthy controls (p=0.019). Anti-GPC antibodies were positive in 4 of 11 (36.4%) patients with CIU and low B12 levels, but only in 2 of 27 (7.4%) healthy controls (p=0.047). In CIU patients, there was no difference in the frequency of IgG H. pylori antibodies between those with low B12 levels and normal B12 levels. Among the 19 patients who had been performed gastric endoscopy, 15 patients (78.9%) had chronic antral gastritis, 2 patients (10.5%) had atrophic gastritis and there were normal findings in 2 patients (10.5%). In conclusion, serum B12 levels were found to be below the normal reference range in 33% of the patients with CIU. An association between low B12 levels and H. pylori could not be shown. The higher frequency of antithyroid and anti-GPC antibodies in patients with low B12 levels suggest that low B12 levels in CIU may be autoimmune in nature.

Topics: Adolescent; Adult; Antibodies, Bacterial; Autoantibodies; Chronic Disease; Female; Helicobacter pylori; Humans; Immunoglobulin G; Male; Middle Aged; Parietal Cells, Gastric; Urticaria; Vitamin B 12; Vitamin B 12 Deficiency

A case of vitamin B12 allergy is reported. Typical eczematous and exanthematic skin lesions appeared after long-term and high-dosed intake of a vitamin B12 drug (Biovital). Patch tests with vitamin B12 were positive. This observation of vitamin B12 allergy we compared with previous published cases.

Topics: Anaphylaxis; Chemical Phenomena; Chemistry; Drug Eruptions; Drug Hypersensitivity; Eczema; Female; Humans; Long-Term Care; Male; Middle Aged; Nausea; Urticaria; Vitamin B 12

Topics: Humans; Intestinal Absorption; Intestinal Diseases; Intestine, Small; Urticaria; Vitamin B 12; Xylose

Topics: Administration, Oral; Aged; Anemia, Pernicious; Drug Hypersensitivity; Dyspnea; Female; Headache; Humans; Hydroxocobalamin; Middle Aged; Urticaria; Vitamin B 12

Topics: Aged; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Lymphocytes; Urticaria; Vitamin B 12

Topics: Blood Chemical Analysis; Humans; Injections; Injections, Intramuscular; Pharmaceutical Vehicles; Urticaria; Vitamin B 12; Vitamin B Complex