vitamin-b-12 and Urinary-Tract-Infections

The essential amino acid L-methionine is a potential compound in the prophylaxis of recurrent or relapsing urinary tract infection due to acidification of urine. As an intermediate of L-methionine metabolism, homocysteine is formed. The objective was to study the metabolism of L-methionine and homocysteine, and to assess whether there are differences between patients with chronic urinary tract infection and healthy control subjects.. A randomized placebo-controlled double-blind intervention study with cross-over design.. Department of Nutritional Physiology, Institute of Nutrition in cooperation with the Department of Internal Medicine III, Friedrich Schiller University of Jena, Germany.. Eight female patients with chronic urinary tract infection and 12 healthy women (controls).. After a methionine-loading test, the volunteers received 500 mg L-methionine or a placebo three times daily for 4 weeks.. Serum and urinary concentrations of methionine, homocysteine, cystathionine, cystine, serine, glycine and serum concentrations of vitamin B12, B6 and the state of folate.. Homocysteine plasma concentrations increased from 9.4+/-2.7 micromol/l (patients) and 8.9+/-1.8 micromol/l (controls) in the placebo period to 11.2+/-4.1 micromol/l (P=0.031) and 11.0+/-2.3 micromol/l (P=0.000), respectively, during L-methionine supplementation. There were significant increases in serum methionine (53.6+/-22.0 micromol/l; P=0.003; n=20) and cystathionine (0.62+/-0.30 micromol/l; P=0.000; n=20) concentrations compared with the placebo period (33.0+/-12.0 and 0.30+/-0.10 micromol/l; n=20). Simultaneously, renal excretion of methionine and homocysteine was significantly higher during L-methionine intake.. Despite an adequate vitamin status, the supplementation of 1500 mg of L-methionine daily significantly increases homocysteine plasma concentrations by an average of 2.0 micromol/l in patients and in control subjects. An optimal vitamin supplementation, especially with folate, might prevent such an increase.

Topics: Adult; Aged; Amino Acids; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Urinary Tract Infections; Vitamin B 12; Vitamin B 6

We present a normotensive, pregnant woman with severe haemolytic anaemia in the third trimester of pregnancy. Owing to normal platelet count diagnoses other than HELLP syndrome were considered and investigated. The patient was treated with nitrofurantoin 3 weeks before presentation and she turned out to have a deficiency of glucose-6-phosphate dehydrogenase. After treatment with blood transfusion, vitamin B12 and folic acid the patient recovered completely. Caesarean delivery was performed because of maternal hypertension and fetal distress at 33 weeks' gestation.

Topics: Adult; Anemia, Hemolytic; Blood Transfusion; Cesarean Section; Female; Folic Acid; Glucosephosphate Dehydrogenase Deficiency; HELLP Syndrome; Humans; Nitrofurantoin; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Pregnancy Trimester, Third; Prenatal Care; Risk Assessment; Urinary Tract Infections; Vitamin B 12

Topics: Anti-Infective Agents; Blood Platelets; Child, Preschool; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Folic Acid Antagonists; Hemoglobins; Histidine; Humans; Infant; Kwashiorkor; Male; Nutrition Disorders; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections; Vitamin B 12

Topics: Anemia, Hypochromic; Anemia, Macrocytic; Erythrocyte Count; Female; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Injections, Intravenous; Iron; Pregnancy; Pregnancy Complications, Hematologic; Reticulocytes; Urinary Tract Infections; Vitamin B 12

Topics: Adolescent; Adrenal Glands; Adult; Aged; Betaine; Cholangitis; Enterocolitis, Pseudomembranous; Female; Hepatitis A; Humans; Infections; Male; Middle Aged; Respiratory Tract Infections; Tissue Extracts; Urinary Tract Infections; Vitamin B 12

Topics: Adult; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Female; Fever; Humans; Male; Middle Aged; Neuralgia; Pain; Pyridoxine; Quinolines; Rheumatic Fever; Urinary Tract Infections; Vitamin B 12