vitamin-b-12 and Ulcer

Recurrent oral ulcer is one of the most prevalent inflammatory ulcerative disorders of the oral mucosa. Due to the indeterminant cause and unpredictable course of the disease, clinical treatment of patients with recurrent oral ulcer is focused on relieving the pain, shortening the course of the disease, and prolonging the intermission period. Numerous chemical and biologic agents have been characterized as beneficial in the treatment of patients with recurrent oral ulcer, but there is currently no definitive therapy available. This study aimed to investigate the clinical effects and tolerability of combined mecobalamin tablets and vitamin E capsules in the treatment of recurrent oral ulcer.. A total of 58 patients with recurrent oral ulcer admitted to our hospital were allocated to receive mecobalamin tablets + vitamin E soft capsules (test group) or Fe complex enzyme gargle only (control group) (n = 29 per group). Changes in parameters such as pain level, as measured on a 10-point visual analog scale (VAS); ulcer status and number of ulcers; proinflammatory cytokine levels; and quality of life, as measured using SF-36, from before to after treatment were measured. Mean intermission time and mean ulcer healing time were calculated. Total effectiveness rate was also calculated. The occurrences of adverse reactions in the two groups were quantified.. The total intermission time interval was significantly longer, the mean ulcer healing time was considerably shorter, the total number of ulcers was appreciably less, and the total effectiveness rate was significantly greater in the test group compared to the control group (all, P < 0.05). The VAS scores were significantly greater after treatment than before treatment in both the test and control groups (mecobalamin + vitamin E, 2.16 [1.09] vs 7.87 [0.51]; control, 3.72 [1.15] vs 7.94 [0.56]; both, P < 0.05). Interleukin (IL)-8, tumor necrosis factor α, and C-reactive protein levels were appreciably down-regulated in both groups when compared to before treatment. In addition, IL-2 concentration and SF-36 scores were much greater after treatment in the test group with respect to the control group. Levels of IL-8, TNF-α, and CRP were significantly lesser in the test group than in the control group (all, P < 0.05).. The combination of mecobalamin tablets and vitamin E soft capsules was effective in the treatment of recurrent oral ulcer. This combination can be used as an adjunctive therapy, offering effective pain control and improving quality of life in patients with oral ulcers.

Topics: Capsules; Humans; Oral Ulcer; Pain; Quality of Life; Ulcer; Vitamin B 12; Vitamin E

Topics: Colchicine; Diagnostic Errors; Folic Acid; Genital Diseases, Male; Herpes Genitalis; Humans; Male; Treatment Outcome; Ulcer; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult

The oral manifestations of glossitis, stomatitis and mucosal ulceration in vitamin B12 deficiency have long been recognised. These oral changes may occur in the absence of symptomatic anaemia or of macrocytosis. The aim of this paper is to describe a retrospective study of the wide range of oral signs and symptoms reported by 14 patients found to have a previously undiagnosed vitamin B12 deficiency. None of the patients described in this study had generalised symptoms sufficiently advanced to arouse suspicions of vitamin B12 deficiency. The essential criteria for the diagnosis of pernicious anaemia are also discussed.

Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Burning Mouth Syndrome; Cheilitis; Female; Glossalgia; Glossitis; Humans; Male; Mouth Diseases; Mouth Mucosa; Retrospective Studies; Stomatitis; Stomatitis, Denture; Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

A full haematology screen was carried out on 398 patients under investigation for recurrent oral ulceration or stomatitis. Thirty-three patients were found to have lowered serum folate and/or red cell folate levels without iron deficiency. Of these only six were found to have a mean corpuscular volume (MCV) outside normal limits or to have recognisable erythrocyte abnormalities. No correlation was found between serum or red cell folate levels and the MCV. Eighteen patients were found to have lowered serum B12 levels without iron deficiency, of these seven were found to have a MCV outside normal limits. A significant negative correlation was found between serum B12 levels and the MCV. It is concluded that haematological screening in these cases should include estimations of serum folate, red cell folate and serum B12 levels even in the face of an apparently normal peripheral blood film.

Topics: Erythrocyte Indices; Female; Folic Acid; Hematologic Tests; Humans; Male; Mouth Diseases; Stomatitis; Ulcer; Vitamin B 12

Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Binding Sites; Blood Sedimentation; Diagnosis, Differential; Female; Folic Acid; Folic Acid Deficiency; Humans; Iron; Iron Deficiencies; Male; Middle Aged; Mouth Diseases; Prospective Studies; Recurrence; Stomatitis, Aphthous; Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Anemia; Biopsy; Blind Loop Syndrome; Chronic Disease; Diarrhea; Gastrointestinal Hemorrhage; Humans; Intestinal Absorption; Intestinal Mucosa; Malabsorption Syndromes; Male; Radiography; Ulcer; Vitamin B 12

Topics: Biopsy; Celiac Disease; Folic Acid; Glucose Tolerance Test; Humans; Intestinal Mucosa; Iron; Jejunum; Lymphadenitis; Male; Middle Aged; Ulcer; Vitamin B 12

Topics: Bone Resorption; Child; Diagnosis, Differential; Female; Foot; Friedreich Ataxia; Glycosaminoglycans; Hand; Humans; Infant; Male; Peripheral Nervous System Diseases; Psoriasis; Radiography; Scleroderma, Systemic; Sex Factors; Syringomyelia; Tabes Dorsalis; Thromboangiitis Obliterans; Tuberculosis, Osteoarticular; Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Atrophy; Blood-Brain Barrier; Bone Diseases; Deafness; Electrophoresis, Disc; Female; Foot Diseases; Humans; Injections, Intramuscular; Spinal Dysraphism; Ulcer; Vestibulocochlear Nerve; Vitamin B 12

Topics: Ascorbic Acid; Collagen Diseases; Corrinoids; Cystitis; Cystitis, Interstitial; Drug Therapy; Humans; Lupus Erythematosus, Systemic; Pyridoxine; Scleroderma, Systemic; Ulcer; Vitamin B 12

Topics: Absorption; Amino Acids; Digestion; Fats; Gastrectomy; Humans; Nutritional Physiological Phenomena; Nutritional Sciences; Nutritional Status; Peptic Ulcer; Physiology; Proteins; Ulcer; Vitamin B 12

Topics: Corrinoids; Cortisone; Hematinics; Hunger; Peptic Ulcer; Pharmacology; Rats; Research; Ulcer; Vitamin B 12; Vitamin B Complex

Topics: Animals; Corrinoids; Hematinics; Peptic Ulcer; Rats; Ulcer; Vitamin B 12

Topics: Corrinoids; Folic Acid; Hematinics; Radiation Injuries; Ulcer; Vitamin B 12

Topics: Cicatrix; Corrinoids; Dermatologic Agents; Hematinics; Humans; Pressure Ulcer; Ulcer; Vitamin B 12

Topics: Animals; Brain; Gizzard, Non-avian; Humans; Peptic Ulcer; Ulcer; Vitamin B 12

Topics: Anti-Bacterial Agents; Gelatin; Humans; Leg; Leg Ulcer; North Carolina; Ulcer; Vitamin B 12

Topics: Anemia; Anemia, Pernicious; Corrinoids; Humans; Male; Penile Diseases; Penis; Ulcer; Vitamin B 12