vitamin-b-12 and Tuberculosis--Pulmonary

Topics: Bilirubin; Choline; Chronic Disease; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Homocysteine; Humans; Lactones; Liver; Liver Diseases; Liver Function Tests; Lung Diseases; Male; Peritonitis; Pleurisy; Silicotuberculosis; Transaminases; Tuberculosis, Pulmonary; Vitamin B 12

The aim of this study was to assess the association of vitamin B12 level and single nucleotide polymorphisms (SNPs) in vitamin B12 metabolic genes with pulmonary tuberculosis (PTB) in Chinese Han population. The plasma vitamin B12 expression level was detected using ELISA. Ten SNPs in six key genes (

Topics: Alleles; Humans; Hypoproteinemia; Oxidoreductases; Polymorphism, Single Nucleotide; Tuberculosis, Pulmonary; Vitamin B 12

Vitamins are known to be associated with immunity and nutrition. Moreover, vitamin deficiency can affect host immunity to various infectious diseases, including tuberculosis. Although patients with tuberculosis often have vitamin D deficiency, little is known about the levels of other vitamins. Here, we aimed to investigate the status of vitamins A, B. We performed a case-control study to investigate the serum vitamin concentrations in 152 patients with tuberculosis and 137 control subjects. The concentrations of vitamin A, vitamin D, vitamin E, homocysteine, and methylmalonic acid were measured using high-performance liquid chromatography (HPLC) or HPLC-tandem mass spectrometry. Patient demographic data and other biochemical parameters were also analyzed.. The serum concentrations of vitamins A, D, and E were significantly lower in patients with tuberculosis than in control subjects (1.4 vs. 2.0 μmol/L, P < 0.001; 10.6 vs. 19.3 ng/mL, P < 0.001; and 22.8 vs. 30.6 μmol/L, P < 0.001, respectively). In contrast, the methylmalonic acid levels were higher in patients with tuberculosis (134.9 vs. 110.8 nmol/L, P < 0.001). The prevalences of vitamin deficiencies were significantly higher in patients with tuberculosis. Moreover, multiple vitamin deficiencies were only observed in patients with tuberculosis (22.4% of all patients with tuberculosis vs. 0% of all control subjects). Positive correlations among vitamin A, D, and E concentrations were observed (vitamins A and D, r = 0.395; vitamins D and E, r = 0.342; and vitamins A and E, r = 0.427, P < 0.001). Body mass index, total cholesterol, low-density lipoprotein, iron, and total iron-binding capacity all showed positive correlations with vitamin A, D, and E concentrations.. Vitamin deficiencies are common in patients with tuberculosis. Further research investigating the clinical importance of vitamin and nutritional status in patients with tuberculosis is needed.

Topics: Adolescent; Adult; Aged; Avitaminosis; Case-Control Studies; Female; Humans; Male; Middle Aged; Nutritional Status; Tuberculosis, Pulmonary; Vitamin A; Vitamin B 12; Vitamin D; Vitamin D Deficiency; Vitamin E; Young Adult

This study surveys the extent and severity of haematological and biochemical abnormalities which occurred in 265 patients with pulmonary tuberculosis, and records the haematological changes that occur with treatment. Anaemia was present in 60 per cent of patients, more frequently in males than in females. Leucocytosis with neutrophilia occurred in 40 per cent, lymphopenia in 17 per cent and monocytopenia in 50 per cent. Platelet count and erythrocyte sedimentation rate were elevated in 52 and 80 per cent respectively. Bone marrow aspiration and trephine biopsy were of limited diagnostic value. Ferritin and vitamin B12 levels were increased in 94 and 57 per cent of subjects respectively whilst serum and red cell folic acid were within normal limits in 83 per cent. The frequency of the important biochemical changes were hyponatraemia (43 per cent) and hypoalbuminaemia (72 per cent); alkaline phosphatase, aspartic transaminase and lactic dehydrogenase levels were elevated in approximately a third of patients possibly due to unsuspected dissemination. There was a close correlation between the acid-fast bacilli in sputum and abnormal values, particularly those of body weight, haemoglobin, platelet count, white cell count and erythrocyte sedimentation rate. Failure of these indices to return to normal was invariably associated with persistent excretion of acid-fast bacilli. We have shown that haematological and biochemical abnormalities in pulmonary tuberculosis are common and may be valuable aids to diagnosis. Some haematological markers also reflect response to treatment.

Topics: Adult; Antitubercular Agents; Blood Cell Count; Blood Sedimentation; Erythrocyte Indices; Female; Ferritins; Humans; Hyponatremia; Male; Middle Aged; Reference Values; Thrombocytosis; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Blood Proteins; Body Weight; Bone Diseases; Calcium; Drainage; Dumping Syndrome; Duodenal Ulcer; Female; Folic Acid; Follow-Up Studies; Gastrectomy; Hemoglobinometry; Humans; Malabsorption Syndromes; Male; Middle Aged; Peptic Ulcer Hemorrhage; Postgastrectomy Syndromes; Postoperative Complications; Prospective Studies; Recurrence; Tuberculosis, Pulmonary; Vagotomy; Vitamin B 12; Vomiting

Topics: Aminosalicylic Acids; Cobalt Isotopes; Humans; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Intrinsic Factor; Schilling Test; Telemetry; Tuberculosis, Pulmonary; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adolescent; Adult; Antitubercular Agents; Appetite; Body Weight; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adult; Aged; Alkaline Phosphatase; Anemia, Hypochromic; Body Weight; Calcium; Duodenal Ulcer; Female; Follow-Up Studies; Gastroenterostomy; Hemoglobins; Humans; Male; Metabolism; Middle Aged; Osteomalacia; Sex Factors; Time Factors; Tuberculosis, Pulmonary; Vagotomy; Vitamin B 12

Topics: Antitubercular Agents; Drug Combinations; Female; Humans; Liver Diseases; Liver Extracts; Male; Middle Aged; Time Factors; Tuberculosis, Pulmonary; Vitamin B 12; Vitamin E; Vitamin K

Topics: Adenosine Triphosphate; Adolescent; Adrenocorticotropic Hormone; Adult; Antitubercular Agents; Ascorbic Acid; Drug Resistance, Microbial; Ethionamide; Female; Heparin; Humans; Injections, Intravenous; Isoniazid; Male; Methods; Middle Aged; Mycobacterium; Pyridoxine; Streptomycin; Thiamine; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Alcoholism; Blood Sedimentation; Divorce; Dumping Syndrome; Duodenal Ulcer; Humans; Intestinal Absorption; Iron; Leukocyte Count; Mycobacterium tuberculosis; Nutrition Disorders; Social Conditions; Sputum; Stomach Ulcer; Sweden; Tuberculosis; Tuberculosis, Pulmonary; Vitamin A; Vitamin B 12

Topics: Child; Child, Preschool; Coenzymes; Female; Humans; Male; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Aminosalicylic Acids; Celiac Disease; Gastrectomy; Humans; Intestinal Absorption; Male; Middle Aged; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adrenal Cortex Hormones; Adult; Antitubercular Agents; Humans; Liver Extracts; Male; Middle Aged; Pyridoxine; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adult; Aged; Aminosalicylic Acids; Blood Cell Count; Feces; Female; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Jejunum; Lipid Metabolism; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Tuberculosis, Pulmonary; Vitamin B 12; Xylose

Topics: Adult; Electrocardiography; Folic Acid; Heart; Humans; Middle Aged; Orotic Acid; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adult; Folic Acid; Humans; Middle Aged; Nucleic Acids; Orotic Acid; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adult; Aged; Cholangitis; Female; Humans; Liver Diseases; Liver Extracts; Male; Mannitol; Middle Aged; Nucleosides; Tuberculosis, Pulmonary; Uridine; Vitamin B 12

Topics: Adult; Anemia, Macrocytic; Cycloserine; Female; Folic Acid Deficiency; Humans; Isoniazid; Male; Middle Aged; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adult; Aminosalicylic Acids; Anemia, Macrocytic; Female; Folic Acid; Folic Acid Deficiency; Humans; Isoniazid; Male; Middle Aged; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Adult; Ascorbic Acid; Chronic Disease; Female; Humans; Injections, Intravenous; Isoniazid; Male; Middle Aged; Pyridoxine; Streptomycin; Thiamine; Tuberculosis, Pulmonary; Vitamin B 12; Vitamins

Topics: Adult; Aminosalicylic Acids; Anemia; Anemia, Sideroblastic; Erythropoiesis; Ethionamide; Female; Folic Acid Deficiency; Glucosephosphate Dehydrogenase Deficiency; Humans; In Vitro Techniques; Isoniazid; Prednisolone; Pyrazinamide; Pyridoxine; Streptomycin; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Aminosalicylic Acids; Humans; Malabsorption Syndromes; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Anemia, Macrocytic; Antitubercular Agents; Blood; Bone Marrow Examination; Female; Folic Acid; Folic Acid Deficiency; Humans; Iron; Male; Middle Aged; Tuberculosis; Tuberculosis, Lymph Node; Tuberculosis, Osteoarticular; Tuberculosis, Pulmonary; Tuberculosis, Renal; Vitamin B 12

Topics: Adolescent; Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Blood Chemical Analysis; Child; Drug Therapy; Geriatrics; Humans; Infant; Isonicotinic Acids; Pharmacology; Rabbits; Research; Streptomycin; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Appetite; Body Weight; Cobalt; Copper; Corrinoids; Drug Synergism; Drug Therapy; Geriatrics; Hematopoiesis; Humans; Iron; Liver Extracts; Lung Neoplasms; Lysine; Manganese; Tissue Extracts; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12; Vitamin B Complex

Topics: Adenine Nucleotides; Adenosine Monophosphate; Heart Diseases; Humans; Pulmonary Heart Disease; Thiamine Pyrophosphate; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Blood; Corrinoids; Niacin; Nicotinic Acids; Serum; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Corrinoids; Feeding and Eating Disorders; Humans; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12