vitamin-b-12 and Stomach-Ulcer

Topics: Adrenal Cortex Hormones; Anemia, Pernicious; Animals; Antibodies; Autoantibodies; Biopsy; Chronic Disease; Gastric Juice; Gastric Mucosa; Gastrins; Gastritis; Humans; Intrinsic Factor; Schilling Test; Stomach; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12

Topics: Esophagitis, Peptic; Gastrectomy; Humans; Ileum; Methods; Postoperative Complications; Pylorus; Stomach; Stomach Ulcer; Transplantation, Autologous; Vitamin B 12

Patients treated in a randomized controlled comparison of management of benign gastric ulcer of the body of the stomach, comprising 50 patients treated by Billroth I partial gastrectomy and 50 patients treated by vagotomy and pyloroplasty and biopsy of the ulcer, were followed up for about five years (range one and a half to eight and a half years). No statistically significant difference has been found between the functional results (Visick grading) of the two groups. There was no operative mortality. Postoperative morbidity (17 against 5) and length of stay in hospital (14 against 10 days) were significantly greater after gastrectomy. Seven patients after vagotomy have been submitted to gastrectomy (three for recurrent gastric ulceration, three for gastric cancer, and one for bleeding), which is a statistically significant excess compared with no reoperation after gastrectomy. While vagotomy and pyloroplasty can be useful to avoid a technically difficult gastrectomy, it cannot be said to replace partial gastrectomy in the treatment of gastric ulcer.

Topics: Clinical Trials as Topic; Folic Acid; Follow-Up Studies; Gastrectomy; Gastrointestinal Hemorrhage; Hemoglobinometry; Humans; Iron; Length of Stay; Postoperative Complications; Pylorus; Recurrence; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer; Vagotomy; Vitamin B 12

As chronic use of antiulcer medications might predispose older persons to cobalamin deficiency, we studied participants (> 65 years) in the clinical examination of the Canadian Study of Health and Aging to test the association between the use of an antiulcer medication (histamine-2 blocker or proton pump inhibitor) at baseline with initiation of cobalamin replacement during the 5 year follow-up period. Of 1054 eligible subjects, 125 (11.7%) were taking an antiulcer medication at baseline. At follow-up, 49 (4.6%) had started cobalamin replacement. Antiulcer medication use at baseline was significantly associated with the initiation of cobalamin therapy (odds ratio 2.56, 95% confidence interval 1.30-5.05), even after adjusting for age, gender and institutional residence (odds ratio 2.61, 95% confidence interval 1.31-5.23). There is an independent association between the use of antiulcer medication and initiation of cobalamin therapy. While the relationship is not unambiguously causal, this finding underscores the need for judicious prescribing of antiulcer medications for older persons.

Topics: Aged; Anti-Ulcer Agents; Canada; Female; Histamine H2 Antagonists; Humans; Male; Omeprazole; Stomach Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

The formation of a benign gastric ulcer in an achlorhydric milieu is a rare phenomenon. Since 1971, only 12 cases have been reported. Early cases were treated surgically for fear of gastric cancer, but since that time such ulcers have been successfully treated medically. The authors describe the case of a patient who had no concomitant ulcerogenic factors and whose ulcer occurred in the gastric cardia at the esophagogastric junction. We believe this is the first case report of a patient with pernicious anemia meeting these conditions.

Topics: Achlorhydria; Aged; Anemia, Pernicious; Female; Humans; Stomach Ulcer; Sucralfate; Vitamin B 12

Topics: Gastrectomy; Humans; Stomach Ulcer; Vitamin B 12

Human gastric mucosal cells were isolated from the resected fundic mucosa of peptic ulcer patients. The intracellular content and secretion of intrinsic factor were estimated by binding to cyano[57Co]cobalamin. The content was maximal in the enriched parietal cell fraction which also displayed the highest H+ production as measured by amino[14C] pyrine uptake. Secretagogues evoked full response after 15 min of incubation: pentagastrin (181% of basal secretion), carbachol (208%), histamine (250%) and dibutyryl cyclic adenosine monophosphate (304%). The phosphodiesterase inhibitor isobutylmethylxanthine was slightly more effective even than dibutyryl cAMP. The response to histamine was abolished by ranitidine, indicating activation of adenylate cyclase via histamine H2 receptors, but remained unaffected by atropine, which in turn blocked the carbachol effect, whereas ranitidine was ineffective. The mean formation rate was 8.4 fmol intrinsic factor/10(6) cells per h under basal conditions and 14.3 fmol in response to histamine.

Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carbachol; Female; Gastric Mucosa; Histamine; Humans; In Vitro Techniques; Intrinsic Factor; Kinetics; Male; Middle Aged; Parietal Cells, Gastric; Pentagastrin; Protein Binding; Stomach Ulcer; Vitamin B 12

Topics: Adult; Aftercare; Aged; Anemia, Hypochromic; Diarrhea; Disseminated Intravascular Coagulation; Embolism; Enterocolitis, Pseudomembranous; Female; Gastric Juice; Humans; Intestinal Absorption; Intestine, Small; Iron; Male; Mesenteric Arteries; Mesentery; Middle Aged; Mitral Valve Insufficiency; Sarcoma; Stomach Ulcer; Vitamin B 12

A comparative experimentation between treatment with large amounts of vitamin B12 alone and associations of intrinsic factor with different concentrations of vitamin B12 in the gastrectomised dog and rat subjected to digestive stress induced by phenylbutazone is reported. This study served to examine the possible therapeutic role of vitamin B12 passive diffusion occurring with large amounts of cyanocobalamine in the digestive tract, and to verify the utility and efficacy of the intrinsic factor contained in the marketed Gastropylore, the composition of which associates an original lyophilisate of suckling lamb gastric mucosa (LLGM) with vitamin B12. Treatments with either of the components alone exerted no protective effect against phenylbutazone-induced ulcerations whereas Gastropylore gave very significant protection (p less than 0.00001). Enhancement of the vitamin did not yield any significant improvement. Weight increase after gastrectomy was clear in the three groups of animals treated with Gastropylore or LLGM containing vitamin B12. Vitamin B12 passive diffusion appears to play no important therapeutic role while the intrinsic factor contained in a lyophilised preparation of lamb gastric mucosa seems to prove useful.

Topics: Animals; Body Weight; Disease Models, Animal; Dogs; Female; Freeze Drying; Gastrectomy; Gastric Mucosa; Intestinal Mucosa; Male; Phenylbutazone; Rats; Sheep; Stomach Ulcer; Tissue Extracts; Vitamin B 12

Topics: Adult; Female; Follow-Up Studies; Gastrectomy; Humans; Male; Middle Aged; Stomach Ulcer; Vitamin B 12

Fasting serum pyridoxal was assayed by an automated microbiological system in 50 patients with endoscopically confirmed active peptic ulceration. Thirty patients had gastric ulceration, 14 had duodenal, four had pyloric canal ulceration, and two had both a gastric and a duodenal ulcer. Serum pyridoxal was below normal in 28 of the gastric ulcer group and in one of the duodenal ulcer group. No difference in the age, sex, drug, alcohol intake, or diet could be distinguished between those two groups.

Topics: Adult; Age Factors; Aged; Biological Assay; Duodenal Ulcer; Euglena gracilis; Female; Folic Acid; Humans; Lacticaseibacillus casei; Male; Middle Aged; Peptic Ulcer; Pylorus; Pyridoxal; Sex Factors; Stomach Ulcer; Vitamin B 12

Topics: Adult; Female; Follow-Up Studies; Gastrectomy; Humans; Male; Middle Aged; Stomach Ulcer; Vitamin B 12

Topics: Anemia, Pernicious; Biopsy; Body Weight; Dumping Syndrome; Duodenal Ulcer; Dyspepsia; Female; Follow-Up Studies; Gastrectomy; Gastric Mucosa; Hemoglobins; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Male; Postgastrectomy Syndromes; Schilling Test; Stomach Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Aged; Alkaline Phosphatase; Anemia, Hypochromic; Binding Sites; Calcium; Diarrhea; Dumping Syndrome; Female; Folic Acid; Follow-Up Studies; Gastrectomy; Hemoglobins; Humans; Iron; Male; Methods; Middle Aged; Phosphorus; Postoperative Complications; Serum Albumin; Serum Globulins; Stomach Ulcer; Vitamin B 12; Vomiting

Topics: Animals; Buffers; Chlorides; Cobalt Isotopes; Dogs; Duodenal Ulcer; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Glycine; Humans; Osmolar Concentration; Pentagastrin; Peptic Ulcer; Potassium; Pyloric Antrum; Pylorus; Sodium; Stimulation, Chemical; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12; Wound Healing

Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Child; Child, Preschool; Chronic Disease; Diarrhea; Duodenal Ulcer; Female; Humans; Iron; Italy; Liver Extracts; Male; Menorrhagia; Menstruation; Metrorrhagia; Middle Aged; Pregnancy; Pregnancy Complications, Hematologic; Stomach Ulcer; Vitamin B 12

Topics: Adult; Age Factors; Aged; Alcohol Drinking; Duodenal Ulcer; Erythrocytes; Follow-Up Studies; Gastrectomy; Gastric Juice; Humans; Intrinsic Factor; Leiomyoma; Methods; Middle Aged; Pepsin A; Postoperative Complications; Schilling Test; Stomach Neoplasms; Stomach Ulcer; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Macrocytic; Duodenal Ulcer; Female; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Jejunum; Male; Peptic Ulcer; Postgastrectomy Syndromes; Stomach Ulcer; Vagotomy; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Alcoholism; Blood Sedimentation; Divorce; Dumping Syndrome; Duodenal Ulcer; Humans; Intestinal Absorption; Iron; Leukocyte Count; Mycobacterium tuberculosis; Nutrition Disorders; Social Conditions; Sputum; Stomach Ulcer; Sweden; Tuberculosis; Tuberculosis, Pulmonary; Vitamin A; Vitamin B 12

Topics: Cobalt Isotopes; Duodenal Ulcer; Gastritis; Humans; Intestinal Absorption; Peptic Ulcer; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12

Topics: Aged; Anemia, Pernicious; Autoantibodies; Body Height; Body Weight; Female; Fluorescent Antibody Technique; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Gastritis; Histamine; Humans; Intrinsic Factor; Iron; Ischemia; Male; Middle Aged; Peptic Ulcer; Polycythemia Vera; Stomach Ulcer; Vitamin B 12

Topics: Adult; Age Factors; Duodenal Ulcer; Female; Gastric Acidity Determination; Gastric Juice; Gastrins; Histamine; Humans; Injections, Subcutaneous; Intrinsic Factor; Male; Methods; Middle Aged; Radioimmunoassay; Stomach Ulcer; Time Factors; Vitamin B 12

Topics: Blood Proteins; Copper; Digestive System; Dumping Syndrome; Duodenum; Follow-Up Studies; Gastrectomy; Humans; Iron; Lipids; Liver; Methods; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12

Topics: Ataxia; Gastrectomy; Humans; Male; Middle Aged; Postgastrectomy Syndromes; Postoperative Complications; Spinal Cord Diseases; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Pernicious; Corrinoids; Cortisone; Dogs; Duodenum; Hematinics; Hyperparathyroidism; Intrinsic Factor; Pathology; Research; Stomach Ulcer; Thyroidectomy; Vitamin B 12

Topics: Adult; Aged; Anemia, Pernicious; Antibodies; Cobalt Isotopes; Gastric Acidity Determination; Gastritis; Histamine; Humans; Immunoassay; Intrinsic Factor; Middle Aged; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12

Topics: Animals; Fasting; Female; Gastric Juice; Hydrocortisone; In Vitro Techniques; Male; Pylorus; Rats; Stomach Ulcer; Vitamin B 12

Topics: Atrophy; Duodenal Ulcer; Gastritis; Gastritis, Atrophic; Humans; Intrinsic Factor; Polyps; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12