vitamin-b-12 and Skin-Neoplasms

Topics: Aflatoxins; Airway Resistance; Animals; Anthracenes; Benzopyrenes; Cricetinae; Female; Heterocyclic Compounds; Humans; Hydrocarbons; Lactones; Lung Neoplasms; Male; Mice; Mouth Neoplasms; Naphthalenes; Nicotiana; Phenols; Plants, Toxic; Rats; Skin Neoplasms; Smoking; Stomach Neoplasms; Urinary Bladder Neoplasms; Vitamin B 12

Vitamin B12 and folate are the major micronutrients that play significant roles in DNA synthesis. Epidemiological studies and clinical evidences displayed alterations in serum concentrations folate and of vitamin B12 in various human malignancies, yet their roles in patients with melanoma have yet to be understood.. To assess circulating vitamin B12 and folate concentrations of patients with melanoma and compare them with other malignant tumors and healthy subjects.. A total of 98 skin melanoma cases from university clinic were enrolled into the study. Serum vitamin B12 and folate concentrations were analyzed by electrochemiluminescence binding assay.. Circulating levels of vitamin B12 in patients with melanoma were similar compared with other malignancies and healthy controls (P > .05). However, melanoma cases had significantly lower serum folate concentrations than healthy control group (P = .04). Melanoma patients with metastatic disease (P = .001) and with short history of disease (P = .05), and those who had active diseases in course of the study (P = .04) had low serum folate concentrations.. Serum levels of folate were found significantly lower in melanoma cases, and this association was stronger for patients with metastatic melanoma; however, no such association was found between melanoma and serum vitamin B12 levels.

Topics: Folic Acid; Humans; Melanoma; Skin Neoplasms; Vitamin B 12

Whereas the prevalence of several cancer types is decreasing, skin malignancies are growing more common every year. Malignant melanoma is the most aggressive form of skin cancer with high metastatic capacity. In most cases, malignant melanoma shows acquired therapy resistance. We evaluated the ability of Ocoxin, a natural compound-based antioxidant and anti-inflammatory nutritional complement, to exert an antitumor effect in melanoma. To do so, the cytotoxicity of Ocoxin in a panel of BRAF-mutated murine and human melanoma cell lines was tested alone and in combination with BRAF inhibitor Vemurafenib. Our results revealed a potent cytotoxic effect of Ocoxin against melanoma cells and a synergic effect when combined with Vemurafenib, reducing viability and increasing apoptosis. Besides, Ocoxin interferes with the cell cycle, impairs the inherent and fibroblast-mediated melanoma cell migration, and reduces resistance to BRAF inhibition. Proteomic analysis revealed reduced tumor secretion of inflammatory factors Galectin-1, Osteopontin, CCL5, and CCL9 upon treatment with Ocoxin. Moreover, RNASeq showed that Ocoxin downregulated the cell cycle and proliferation-related genes. In vivo, Ocoxin reduced the number of lung metastasis of YUMM-1.7 melanoma cells. Therefore, Ocoxin arises as a good candidate for clinical trials analyzing the beneficial effects in patients suffering from this cutaneous malignancy.

Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Cancer-Associated Fibroblasts; Cell Line, Tumor; Drug Resistance, Neoplasm; Folic Acid; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Pantothenic Acid; Plant Extracts; Protein Kinase Inhibitors; Proteomics; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Vemurafenib; Vitamin B 12; Vitamin B 6; Zinc Sulfate

Postsurgical skin healing can result in different scars types, ranging from a fine line to pathologic scars, in relation to patients' intrinsic and extrinsic factors. Although the role of nutrition in influencing skin healing is known, no previous studies investigated if the vegan diet may affect postsurgical wounds.. The aim of this study was to compare surgical scars between omnivore and vegan patients.. This is a prospective observational study. Twenty-one omnivore and 21 vegan patients who underwent surgical excision of a nonmelanoma skin cancer were enrolled. Postsurgical complications and scar quality were evaluated using the modified Scar Cosmesis Assessment and Rating (SCAR) scale.. Vegans showed a significantly lower mean serum iron level (p < .001) and vitamin B12 (p < .001). Wound diastasis was more frequent in vegans (p = .008). After 6 months, vegan patients had a higher modified SCAR score than omnivores (p < .001), showing the worst scar spread (p < .001), more frequent atrophic scars (p < .001), and worse overall impression (p < .001).. This study suggests that a vegan diet may negatively influence the outcome of surgical scars.

Topics: Aged; Aged, 80 and over; Cicatrix; Diet, Vegan; Feeding Behavior; Female; Humans; Iron; Male; Middle Aged; Prospective Studies; Severity of Illness Index; Skin Neoplasms; Surgical Wound; Surgical Wound Dehiscence; Vitamin B 12; Wound Healing

The CD4(+) CD56(+) hematodermic/plasmacytoid dendritic cell tumor is a rare, highly aggressive, systemic neoplasm for which effective therapies have not yet been established. These tumors express CD4, CD56, CD123, and T-cell leukemia/lymphoma (TCL)-1 and are clinically characterized by cutaneous involvement with spread to bone marrow and blood, and poor prognosis with current chemotherapy regimens. We describe a Caucasian woman who presented with plasmacytoid dendritic cell tumor, but an absence of systemic symptoms. Clinically, multiple cutaneous lesions were brown to violaceous firm nodules on the face, arms, and trunk. The patient underwent two courses of cyclophosphamide, Adriamycin, vincristine, and prednisone chemotherapy but relapsed quickly. The investigational agent, pralatrexate (30 mg/m(2)) was given weekly with vitamin B12 and folic acid and resulted in remarkable clinical response with regression of skin tumors. Our observation highlights pralatrexate as a promising therapeutic option for hematodermic/plasmacytoid dendritic cell lymphoma/leukemias.

Topics: Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; CD4 Antigens; CD56 Antigen; Cyclophosphamide; Dendritic Cells; Doxorubicin; Drug Therapy, Combination; Female; Folic Acid; Humans; Killer Cells, Natural; Lymphoma, T-Cell; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prednisone; Skin Neoplasms; Treatment Outcome; Vincristine; Vitamin B 12

Topics: Animals; Male; Methods; Methylcholanthrene; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Vitamin B 12

Topics: Adrenal Gland Neoplasms; Humans; Infant, Newborn; Infant, Newborn, Diseases; Liver Neoplasms; Male; Mandelic Acids; Neoplasm Metastasis; Neuroblastoma; Prognosis; Skin Neoplasms; Vitamin B 12

Topics: Aged; Female; Hemangiosarcoma; Humans; Infant; Liver Neoplasms; Male; Neoplasm Metastasis; Neuroblastoma; Skin Neoplasms; Vitamin B 12

Topics: Cysts; Dermatitis, Exfoliative; Dermatology; Drug Eruptions; Eczema; Lead Poisoning; Liver Diseases; Psoriasis; Quinolines; Skin Neoplasms; Toxicology; Vitamin B 12