vitamin-b-12 and Skin-Diseases

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include hyperpigmentation (most commonly); hair and nail changes; and oral changes, including glossitis. Additionally, several dermatologic conditions, including vitiligo, aphthous stomatitis, atopic dermatitis, and acne are related to cobalamin excess or deficiency. The cutaneous complications of cobalamin therapy include acne, rosacea, and allergic site reactions, or anaphylaxis with cobalamin injections. As cobalt is a component of cobalamin, patients with cobalt sensitivity have been reported to have cutaneous manifestations when receiving cobalamin replacement therapy.

Topics: Animals; Cobalt; Humans; Skin Diseases; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex

Multifunctional systems must maintain homeostasis. Man is an ideal example of a system that constantly aspires to attain optimal regulation, even under the stress of severe disease. We assume that there are universal, interchangeable (as required) biologically active substances that regulate the system and try to keep it in balance. We propose that one of these substances is vitamin B12. Why vitamin B12? The list of organs and body systems in which vitamin B12 plays a functional role is constantly being added to. Vitamin B12 affects the normal growth of children, the peripheral and central nervous systems, bone marrow, skin, mucous membranes, bones, and vessels. It is possible that even when the serum cobalamin level is normal, treatment with vitamin B12 could correct defects caused by other biologically active substances. We call this phenomenon the "Master Key" effect. We suggest that this "Master Key" concept can be tested by treating diseases, such as recurrent stomatitis, various forms of hyperpigmentation, trophic ulcers, and burns, with vitamin B12, even if the B12 serum level is normal.

Topics: Animals; Avitaminosis; Cardiovascular Diseases; Dogs; Growth; Humans; Infant; Male; Nervous System Diseases; Skin Diseases; Vitamin B 12

Topics: Amino Acids, Sulfur; Bone Diseases; Cystathionine beta-Synthase; Eye Diseases; Homocysteine; Homocystine; Homocystinuria; Humans; Intestinal Absorption; Methyltransferases; Nervous System Diseases; Skin Diseases; Tetrahydrofolate Dehydrogenase; Thrombosis; Vitamin B 12

Narrowband UVB phototherapy (NB-UVB) is a mainstay in the treatment of numerous inflammatory dermatoses. Whereas, a wealth of studies has shown that NB-UVB treatment increases 25-hydroxyvitamin D3 (25(OH)D) levels, only sparse and controversial data exist on its effect on serum folate and cobalamin.. To determine whether exposure to NB-UVB alters serum folate or cobalamin levels.. A single-centre, prospective, open observational study on 101 patients subjected to NB-UVB phototherapy between late fall and early spring. Serum folate, 25(OH)D and cobalamin levels were measured after 0, 12, 24 and 36 NB-UVB exposures.. After 12 NB-UVB exposures a significant decrease of mean serum folate (-1.0 nmol/L; P = 0.03) and cobalamin (-14.5 pmol/L, P = 0.03) levels was observed whereas serum levels of 25(OH)D showed a significant increase (35.4 nmol/L, P < 0.0001).. A standard course of NB-UVB induces a small but significant decrease of serum folate and cobalamin levels.

Topics: Calcifediol; Folic Acid; Humans; Phototherapy; Prospective Studies; Skin Diseases; Ultraviolet Rays; Vitamin B 12

Topics: Betaine; Biopsy; Child; Drug Therapy, Combination; Homocystinuria; Humans; Injections; Leucovorin; Male; Medication Adherence; Skin; Skin Diseases; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins; Wound Healing

Vitamin B. A retrospective chart review of vitamin B. Forty-three infants, 30 boys and 13 girls, aged 4 to 27 months, with vitamin B. Cutaneous findings are a common feature of vitamin B

Topics: Child, Preschool; Female; Humans; India; Infant; Male; Retrospective Studies; Skin Diseases; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Homocysteine; Humans; Infant; Infant Nutrition Disorders; Male; Methylmalonic Acid; Skin Diseases; Vitamin B 12

Inflammatory dermatoses in conjunction with inflammatory bowel disease (IBD) comprise a diverse range of disorders. Some but not all of these respond to conventional treatments for the underlying IBD, such as immunomodulating or antibiotic treatments. We describe our experience with high dose vitamin B₁₂, where conventional therapies have failed.. The first case had pouchitis complicated by perianal abscesses and a recto-vaginal fistula. The second case had biopsy proven hidradenitis suppurativa affecting the perianal, inguinal and pubic skin. High dose vitamin B₁₂ appeared to be the major factor in preventing the recurrence of suppuration in both patients. Neither patient had vitamin B₁₂ deficiency. Open label experience: high dose vitamin B₁₂ treatment of a further 10 consecutive IBD patients with dermatoses was thought to provide benefit to six of them, but did not appear useful in four patients with perianal Crohn's disease with fistulae as the only manifestation of cutaneous disease.. There appears to be a subset of IBD patients with perianal and more distant inflammatory dermatoses, who benefit from high dose vitamin B₁₂ treatment. Clinical trials in IBD patients with biopsy-characterised suppurative dermatoses will be required in order to properly define the role of this safe and economical therapy.

Topics: Adolescent; Adult; Female; Hidradenitis Suppurativa; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Skin Diseases; Suppuration; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Young Adult

In recent years there has been increasing recognition that the pattern of presentation of coeliac disease may be changing. The classic sprue syndrome with diarrhoea and weight loss may be less common than the more subtle presentations of coeliac disease such as an isolated iron deficiency anaemia. As a result, the diagnosis of this treatable condition is often delayed or missed. Recent serologic screening tests allow non-invasive screening to identify most patients with the disease and can be applied in patients with even subtle symptoms indicative of coeliac disease. Both benign and malignant complications of coeliac disease can be avoided by early diagnosis and a strict compliance with a gluten free diet.. The aim of this study is to evaluate the trends in clinical presentation of patients diagnosed with adult coeliac disease. In addition, we studied the biochemical and serological features and the prevalence of associated conditions in patients with adult coeliac disease.. This is an observational, retrospective, cross-sectional review of the medical notes of 32 adult patients attending the specialist coeliac clinic in a district general hospital.. Anaemia was the most common mode of presentation accounting for 66% of patients. Less than half of the patients had any of the classical symptoms of coeliac disease and 25% had none of the classical symptoms at presentation. Anti-gliadin antibodies, anti-endomysial antibody and anti-tissue transglutaminase showed 75%, 68% and 90% sensitivity respectively. In combination, serology results were 100% sensitive as screening tests for adult coeliac disease. Fifty nine percent patients had either osteoporosis or osteopenia. There were no malignant complications observed during the follow up of our patients.. Most adults with coeliac disease have a sub clinical form of the disease and iron deficiency anaemia may be its sole presenting symptom. Only a minority of adult coeliac disease patients present with classical mal-absorption symptoms of diarrhoea and weight loss. Patients with atypical form of disease often present initially to hospital specialists other than a gastro-enterologist. An awareness of the broad spectrum of presentations of adult coeliac disease, among doctors both in primary care and by the various hospital specialists in secondary care, is necessary to avoid delays in diagnosis. It is important to include serological screening tests for coeliac disease systematically in the evaluation of adult patients with unexplained iron deficiency anaemia or unexplained gastro-intestinal symptoms and in those who are considered to be at increased risk for coeliac disease.

Topics: Adult; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Autoantibodies; Bone Density; Celiac Disease; Cross-Sectional Studies; Erythrocyte Indices; Female; Ferritins; Folic Acid; Gliadin; Humans; Intestine, Small; Male; Middle Aged; Muscle Fibers, Skeletal; Osteoporosis; Retrospective Studies; Rural Population; Skin Diseases; Transglutaminases; Vitamin B 12

Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism. We examined whether single nucleotide 677 C-->T mutation in the MTHFR gene could affect the occurrence of skin lesions in endemic arsenic poisoning.. Fifty individuals with arsenic-induced skin lesions were identified as cases, and 35 individuals without skin lesions from the same village were selected as controls. The MTHFR C677T polymorphism was analyzed by PCR-RFLP method, serum folic acid and Vitamin B12 were determined by microbiological assay and the electrochemiluminescence immunoassay, respectively.. The frequencies of TT genotype and T allele in case group were 34.0% and 56.0%, respectively, and were not significantly different from those in controls. There was no significant difference between case and control group in the levels of folic acid and Vitamin B12 in serum. Compared to subjects carrying the CC genotype and having the level of folic acid above 10.5 nmol/L, other subjects were at elevated risk of skin lesions, but the 95% CI of both crude OR and adjusted OR (controlled for age, gender, smoking and arsenic level in drinking water) include 1.. This study did not find the relationship between MTHFR gene (677C-->T) mutation and skin lesions in endemic arsenic poisoning.

Topics: Adult; Aged; Alleles; Arsenic Poisoning; Female; Folic Acid; Genotype; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Middle Aged; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Skin Diseases; Vitamin B 12

Fifty patients with various long lasting skin diseases were examined. Past history and digestive-nutritional symptoms were recorded. Two or three samples of distal duodenum, elimination of fecal fat and d-xylose absortion test were intended to be performed in all patients, but this coincident parameters were obtained in only 35 patients. Twenty two of these patients were classified as abnormal by 1 of the 3 investigations (62,85%), and 9 (25,71%) were abnormal by 2 criteria. In addition to these usual studies, vit B12 and folic acid absortion were tested in 12 and 23 cases respectively. Distribution does not allow for comparison of the "sensibility" of such tests with the forementioned ones. While only 2 of the 12 patients showed defective absorption of B12, 8 of 22 cases presented with defect of absorption of folic acid. Of this last group, 5 were cases of eritrodermia (the test was performed in 6 cases with this diagnosis). In the total series of 50 cases, including those not thoroughly studied, 27 (54%) presented at least with one abnormal study. These observations point to the possible frequency of intestinal absorption alterations, in several skin diseases, though of moderate degree and pertaining to variable absorption functions. They validate the prosecution of the study, with the aim of clarifying the etio-pathogenesis of some dermatological entities and trying to contribute to their therapy.

Topics: Adolescent; Adult; Female; Folic Acid; Humans; Intestinal Absorption; Intestine, Small; Malabsorption Syndromes; Male; Middle Aged; Skin Diseases; Vitamin B 12

Dyskeratosis congenita is a rare genodermatosis whose hematologic complications include pancytopenia of variable time of onset, a propensity for opportunistic infections, and neoplasia. A family in which the disorder segregated in 3 generations and involved 9 members is reported, and the hematologic data of the 46 previously reported cases are reviewed.

Topics: Adult; Alkaline Phosphatase; Blood Coagulation; Bone Marrow; Fetal Hemoglobin; Folic Acid; Humans; Keratosis; Leukoplakia; Male; Nails; Pancytopenia; Pedigree; Pigmentation Disorders; Skin Diseases; Vitamin B 12

Organ-specific antibodies were looked for in 26 patients with lichen sclerosus. Ten of the 25 female patients (40%) had organ-specific antibodies to thyroid cytoplasm and 11 (44%) had organ-specific antibodies to gastric parietal cells. Both values were significantly greater than those obtained in age-matched controls. None of the sera from patients with lichen sclerosus contained antibodies to steroid-producing tissues. No organ-specific antibodies were found in the one male patient.The findings suggest that lichen sclerosus may be related to an autoimmune process.

Topics: Adolescent; Adult; Aged; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Cytoplasm; England; Female; Gastric Mucosa; Humans; Intrinsic Factor; Lichens; Male; Middle Aged; Organ Specificity; Radioimmunoassay; Scotland; Skin Diseases; Thyroid Gland; Vitamin B 12; Vitiligo

Topics: Achlorhydria; Anemia, Pernicious; Celiac Disease; Child; Eye Manifestations; Gastric Mucosa; Glossitis; Growth Disorders; Humans; Injections, Intramuscular; Intestinal Mucosa; Intrinsic Factor; Male; Neurologic Manifestations; Paresthesia; Skin Diseases; Skin Manifestations; Vitamin B 12; Vitiligo

The excretion in the urine of (58)Co after an oral dose of (58)Co vitamin B(12) given together with intrinsic factor has been found to be reduced in a number of patients with psoriasis, eczema, and other less common dermatoses. There is a correlation between the abnormality and the extent of the rash. A reduced glomerular filtration rate was found in a few of the patients in whom it was measured, and this must have been responsible, at least in part, for the reduced excretion of vitamin B(12) in these patients, but abnormal vitamin B(12) excretion also occurred in the absence of impaired renal function. Our evidence is insufficient to show whether malabsorption or increased tissue utilization of vitamin B(12) was the explanation in other cases. Certainly a number of patients had steatorrhoea, and in these it is most likely that malabsorption was the major factor. In patients without steatorrhoea a lone malabsorption of vitamin B(12) cannot be excluded. A decreased serum concentration of vitamin B(12) was found in only one of the patients.

Topics: Adult; Aged; Celiac Disease; Cobalt Isotopes; Creatinine; Darier Disease; Eczema; Fats; Feces; Female; Glomerular Filtration Rate; Humans; Ichthyosis; Lichen Planus; Malabsorption Syndromes; Male; Metabolic Clearance Rate; Middle Aged; Pityriasis Rubra Pilaris; Psoriasis; Skin Diseases; Vitamin B 12

Topics: Humans; Liver Extracts; Porphyrias; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Dermatology; Hematinics; Humans; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Hematinics; Humans; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Hematinics; Humans; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Hematinics; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Humans; Hypersensitivity; Immune System Diseases; Skin Diseases; Vitamin B 12

Topics: Dermatitis, Seborrheic; Hematinics; Humans; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Dermatitis, Seborrheic; Hematinics; Humans; Skin Diseases; Vitamin B 12

Topics: Corrinoids; Folic Acid; Humans; Hypersensitivity; Skin Diseases; Vitamin B 12; Vitamin B Complex

Topics: Corrinoids; Humans; Hypersensitivity; Immune System Diseases; Skin Diseases; Vitamin B 12