vitamin-b-12 and Skin-Diseases--Vascular

Nicolau Syndrome, also known as livedo-like dermatitis (LLD) or embolia cutis medicamentosa (ECM) is an infrequent complication following intramuscular and intra-articular injection of various drugs. This rare entity is characterized by severe pain and erythematous-ecchymotic reticular lesions at the injection site, which in many cases lead to necrotic ulcers and scarring. We report three cases of Nicolau Syndrome following injection of diclofenac, penicillin G, and cyanocobalamin.

Topics: Adult; Diclofenac; Female; Humans; Injections, Intramuscular; Male; Penicillin G; Skin; Skin Diseases, Vascular; Syndrome; Vitamin B 12

Topics: Adult; Female; Folic Acid; Humans; Hyperhomocysteinemia; Leg; Male; Middle Aged; Skin Diseases, Vascular; Vitamin B 12; Vitamin B 6

Nicolau syndrome (NS), also known as livedo-like dermatitis or embolia cutis medicamentosa, is a very rare complication of intramuscular and intraarticular injection of various drugs.. We herein report a case of NS developing approximately 2 h after the intramuscular administration of vitamin K1 in an extremely low birth weight premature newborn. To our knowledge, this patient is the youngest case suffering from such a livedoid skin necrosis and the first case of neonatal NS developing due to intramuscular administration of vitamin K1.

Topics: Drug Eruptions; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Injections, Intramuscular; Male; Skin; Skin Diseases, Vascular; Syndrome; Vitamin B 12; Vitamin B Complex; Vitamin K Deficiency Bleeding

Topics: Anemia, Pernicious; Humans; Male; Middle Aged; Skin Diseases, Vascular; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency