vitamin-b-12 and Rosacea

Rosacea is a chronic inflammatory skin disease with a multifactorial etiology. Recently, associations between serum homocysteine (Hcy) levels and inflammatory skin diseases, such as psoriasis and hidradenitis suppurativa, have been reported. However, no study has explored the levels of serum Hcy, folic acid, and vitamin B. To investigate serum Hcy, vitamin B. This case-control study included 138 PPR patients and 58 healthy controls. The serum levels of Hcy, vitamin B. Serum vitamin B. Our results suggest a possible association between hyperhomocysteinemia and vitamin B

Topics: Case-Control Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Rosacea; Vitamin B 12; Vitamins

Rosacea fulminans is a rare variant of rosacea conglobata that occurs almost exclusively in women well past adolescence. The aetiology is unknown, although immunological, hormonal, and vascular factors have been suggested. We report the case of a 17-year-old girl with rosacea fulminans that was temporally associated with daily ingestion of high-dose vitamin B supplements. The onset was sudden and cosmetically disabling. The eruption improved when the vitamin supplement was discontinued and a therapeutic regimen including isotretinoin and methylprednisolone was introduced. It seems appropriate to consider the possibility of such a vitamin B-triggered condition in cases of subjects presenting new or exacerbating facial eruptions.

Topics: Adolescent; Dietary Supplements; Dose-Response Relationship, Drug; Drug Eruptions; Facial Dermatoses; Female; Follow-Up Studies; Humans; Risk Assessment; Rosacea; Severity of Illness Index; Vitamin B 12; Vitamin B 6