vitamin-b-12 and Remission--Spontaneous

We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. or oral vitamin B12. Clinical picture was characterized by papules and pustules located on the face. In three patients, similar lesions were also present on the neck, shoulders, chest, and upper portion of the back. Comedones and cysts were absent. In two patients, serum vitamin B12 levels were very high. Histopathologic examination in one patient revealed an eosinophilic folliculitis. Spontaneous and complete remission was observed in all patients 3-6 weeks after vitamin B12 discontinuation.

Topics: Acneiform Eruptions; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Eruptions; Female; Humans; Middle Aged; Prognosis; Remission, Spontaneous; Risk Assessment; Vitamin B 12; Withholding Treatment; Young Adult

Topics: Anti-Bacterial Agents; Child; Fats; Folic Acid; Humans; Intestinal Absorption; Intestinal Neoplasms; Intestine, Small; Intestines; Jejunum; Lymphoma; Remission, Spontaneous; Sprue, Tropical; Vitamin B 12; Water

Impaired Vitamin B12 absorption after significant ileal resection has been reported to be permanent, although partial recovery after ileal bypass can occur. Three children are presented in whom Vitamin B12 malabsorption returned to normal 6-8 years after ileal resection. This was due probably to adaptation of the remaining small bowel, although spontaneous resolution of bacterial overgrowth is a possible explanation. An abnormal Schilling test after ileal resection does not automatically imply the need for life-long Vitamin B12 injections.

Topics: Child; Female; Humans; Ileum; Infant, Newborn; Intestinal Absorption; Longitudinal Studies; Malabsorption Syndromes; Male; Remission, Spontaneous; Vitamin B 12

The effects of Prednisone therapy at two patients with pernicious anemia were studied on haematologic response, gastric secretion and gastric mucosal hystology. The treatment resulted in each case in correctin of the megaloblastic to normoblastic erythropoesis, and increse in reticulocytes, hemoglobin level and red cell count. Schilling-s test was normalised in one case that means that Prednison enchanced B12 absorption. Gastric secretion of acid and gastric hystology were not respond during the Prednisone therapy. It was discused about immunological problems in pernicious anemia which are very important and required continued investigations.

Topics: Anemia, Pernicious; Antibody Formation; Drug Synergism; Humans; Prednisone; Remission, Spontaneous; Vitamin B 12

A 45-year-old woman from Mendoza, Argentina, was severely bitten by a dog that died 4 days later. Before death, the dog was nervous, aggressive, and had occasional seizures. Ten days after the woman had been bitten, rabies vaccine treatment was begun: 14 daily doses of suckling mouse brain vaccine followed by 2 booster doses. Twenty-one days after the biting episode, she developed a cerebellar striatal syndrome, which persisted throughout several months, and severe encephalitic symptoms, which persisted for 75 days. After 13 months, recovery was nearly complete. The patient's serum and cerebrospinal fluid contained rabies-neutralizing antibodies reaching maximum titers of 1:640 000 and 1:160 000, respectively. Titers of this magnitude have never been previusly recorded after suckling mouse brain vaccine treatment. This phenomenon, together with the epidemiologic, clinical, and laboratory data presented, supports the conclusion of a nonfatal case of rabies in man.

Topics: Adrenocorticotropic Hormone; Antibodies, Viral; Betamethasone; Biperiden; Diazepam; Diphenhydramine; Female; Follow-Up Studies; Humans; Immunization, Secondary; Infusions, Parenteral; Middle Aged; Phenytoin; Rabies; Rabies Vaccines; Remission, Spontaneous; Thiamine; Vitamin B 12

A patient with subacute eosinophilic leukemia is presented, with full recognition of the controversy surrounding that entity. Serum vitamin B12 and B12-binding protein studies and simultaneous complete blood counts were done before and during 6 months of high-dose, intermittent combination chemotherapy. The patient presented with extremely high levels of serum vitamin B12, unsaturated B12-binding capacity, and transcobalamin I, all of which resembled the highest values seen in chronic myelogenous leukemia. Serial studies, during and after remission induction, showed a precipitous fall of serum vitamin B12 and unsaturated B12-binding capacity to normal levels. The data show that transcobalamin I levels, which eventually reached low-normal range, correlate best with the level of circulating and bone marrow eosinophils. Transcobalamin II and serum third binder appeared to be normal throughout the patient's course. The B12-binding protein abnormalities are not considered diagnostic of eosinophilic leukemia.

Topics: Adult; Alpha-Globulins; Beta-Globulins; Cyclophosphamide; Cytarabine; Eosinophils; Humans; Leukemia; Male; Prednisone; Protein Binding; Remission, Spontaneous; Vincristine; Vitamin B 12

Topics: Adult; Female; Humans; Remission, Spontaneous; Sarcoidosis; Vitamin B 12

Hyman, Michael P., and Reiquam, C. W.: Monitoring the course of chronic granulocytic leukemia with vitamin B 12-binding proteins. Am J Clin Pathol 63: 796-803, 1975. Vitamin B 12-binding protein levels (UBBC) have been used in the diagnosis of chronic granulocytic leukemia (CGL), but little data on the course of these patients and the fluctuation of their UBBC are available. Serial UBBC were determined for 12 patients with CGL over various periods of time. Some patients remained in relapse aapse. Throughout, the B 12-binding protein levels were a faithful monitor of each patient's course. The beta/alpha ratio, indicating the relative amount of the binding protein fractions probably reflects the clinical status of the patient in a way that is not presently utilizable. Measurement of B 12-binding proteins during the course of chronic granulocytic leukemia may prove helpful in the long-term care of these patients. (Key words: Vitamin B 12-binding proteins; Chronic granulocytic leukemia.)

Topics: Carrier Proteins; Humans; Leukemia, Myeloid; Leukocyte Count; Protein Binding; Recurrence; Remission, Spontaneous; Time Factors; Vitamin B 12

Acquired erythroblastic aplasia of adults is a rare disease characterised by the absence of red cell precursors in the bone marrow. In a 34-year-old female patient the disease has been known for seven years. A partial remission had at first been achieved with glucocorticoids but regular transfusions had been necessary since 1971. Treatment with cyclophosphamide produced a remission which has lasted for over twelve months up to now. Histology of the bone marrow biopsy shows the appearance of active erythropoiesis after cyclophosphamide treatment which reflects well the clinical course.

Topics: Adult; Anabolic Agents; Anemia, Aplastic; Antibody Formation; Antilymphocyte Serum; Azathioprine; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prednisone; Prognosis; Remission, Spontaneous; T-Lymphocytes; Testosterone; Vitamin B 12

We have described a case of chronic arsenic intoxication associated with pancytopenia and megaloblastic erythropoiesis. The patient had the typical laboratory manifestations of effective erythorpoiesis due to a megaloblastic process, including macroovalocytes, mild pancytopenia, low reticulocyte index, increased marrow cellularity with erythroid hyperplasia, and morphologic evidence of megaloblastic maturation in the marrow. The patient's serum folate and vitamin B12 were normal, and the anemia regressed without therapy. Our case suggests that the combination of megaloblastosis with normoblastic or megaloblastic karyorrhexis,should raise the suspicion of arsenic intoxication in the mind of the observer. In addition, arsenic should be added to the list of agents causing a reversible megaloblastic anemia.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Arsenic; Arsenic Poisoning; Bone Marrow Examination; Erythropoiesis; Folic Acid; Hair; Humans; Keratosis; Liver; Male; Middle Aged; Nails; Neural Conduction; Neurologic Manifestations; Remission, Spontaneous; Reticulocytes; Vitamin B 12

Topics: Anemia, Pernicious; Humans; Intrinsic Factor; Leiomyoma; Male; Middle Aged; Muscle, Smooth; Remission, Spontaneous; Schilling Test; Stomach Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency; Vitiligo

Acute promyelocytic leukaemia (A.P.L.) is a rare but important type of acute myeloid leukaemia characterized by major bleeding in association with thrombocytopenia, a specific peripheral blood and bone marrow picture, low plasma fibrinogen, and the presence in the serum of fibrin degradation products. These last abnormalities are related to the disseminated intravascular consumption of coagulation factors with secondary fibrinolysis. A.P.L. requires early recognition and urgent treatment. With optimal management up to half of the patients may achieve complete remission of two years or more. Undoubtedly patients with A.P.L. do especially well when treated in special centres and some patients with A.P.L. now die before the nature of their disease is recognized. Increased familiarity with the problem, which has been known for nearly 20 years, should yield great dividends for those few patients who have this disease.

Topics: Acid Phosphatase; Binding Sites; Bone Marrow Cells; Erythrocytes; Factor V; Factor VIII; Fibrinogen; Hematuria; Hemorrhage; Heparin; Humans; Leukemia, Myeloid; Leukocyte Count; Peroxidases; Platelet Transfusion; Prognosis; Prothrombin; Purpura; Remission, Spontaneous; Thrombocytopenia; Vitamin B 12

Topics: Aged; Cobalt; Humans; Injections; Middle Aged; Muscle Cramp; Remission, Spontaneous; Time Factors; Vitamin B 12

Topics: Adult; Alpha-Globulins; Animals; Antibodies; Antigens; Autoradiography; Beta-Globulins; Blood Proteins; Cobalt Isotopes; Electrophoresis; gamma-Globulins; Humans; Immunoelectrophoresis; Leukemia, Myeloid; Leukocyte Count; Leukocytes; Protein Binding; Rabbits; Remission, Spontaneous; Vitamin B 12

Topics: Cytarabine; Folic Acid; Humans; Leukemia, Erythroblastic, Acute; Mercaptopurine; Methotrexate; Prednisone; Pyridoxine; Remission, Spontaneous; Vitamin B 12

Topics: Adult; Bone Marrow Examination; Cytarabine; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Protein Binding; Remission, Spontaneous; Spleen; Vitamin B 12

Topics: Anemia, Pernicious; Blood Proteins; Carrier Proteins; Centrifugation, Density Gradient; Child; Chromatography, Gel; Cobalt Isotopes; Electrophoresis; Fasting; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Leukocytes; Molecular Weight; Polycythemia Vera; Protein Binding; Proteins; Remission, Spontaneous; Saliva; Tears; Vitamin B 12

Topics: Anemia, Macrocytic; Biological Transport; Blood Protein Disorders; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cobalt Isotopes; Electrophoresis, Disc; Erythrocyte Count; Female; Genes, Recessive; Hematocrit; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pedigree; Protein Binding; Remission, Spontaneous; Reticulocytes; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Anemia, Macrocytic; Bacteria; Biopsy; Bone Marrow Examination; Erythrocyte Count; Female; Folic Acid; Hemoglobins; Humans; Intestinal Absorption; Intestine, Small; Jejunum; Male; Oxytetracycline; Remission, Spontaneous; Reticulocytes; Sprue, Tropical; Sulfaguanidine; Sulfonamides; Vitamin B 12; Xylose