vitamin-b-12 and Pruritus

Topics: Aged; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibodies, Antinuclear; Biopsy; Comorbidity; Esomeprazole; Female; Humans; Lupus Erythematosus, Cutaneous; Mometasone Furoate; Polypharmacy; Pregnadienediols; Pruritus; Remission Induction; Thiamine; Vitamin B 12; Vitamin B 6

Topics: Adrenocorticotropic Hormone; Amino Acids; Cholestyramine Resin; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; gamma-Globulins; Hepatitis A; Hepatitis B; Humans; Pruritus; Rest; Vitamin B 12; Vitamin E; Vitamin K

Psoriasis is a chronic inflammatory skin disease affecting 2%-3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B

Topics: Adult; Aged; Emollients; Female; Humans; Male; Middle Aged; Pruritus; Psoriasis; Quality of Life; Single-Blind Method; Treatment Outcome; Vitamin B 12; Young Adult

The present study was designed to explore the efficacy of locally injected thiamine or cobalamin in relieving itch or pain and improving the daily living activities among patients with herpetic itching.. Eighty eligible patients with herpetic itching with a worst itching score of ≥ 4 were randomized to receive locally injected thiamine (B1 group), cobalamin (B12 group), lidocaine (LD group), or combination of thiamine and cobalamin (COB group) for 4 weeks. The treatment efficacy was assessed based on the patients' pruritus and pain severity, global impression of change, and activities of daily living and quality of life.. After 7 days, thiamine yielded a significant itch relief, cobalamin yielded a significant pain relief, and their combination significantly relieved both pain and itch; which all continued till the endpoint (all Ps<0.001). However, lidocaine did not provide significant itch or pain relief than the other groups. Sixteen patients in the thiamine group achieved ≥ 30% itch reduction; 18 patients in the cobalamin group obtained ≥ 30% pain reduction; and 18 patients achieved ≥ 30% itch reduction and 19 patients obtained ≥ 30% pain reduction in the combination group. The activities of daily living and quality of life data at the endpoint were consistent with a significant benefit in the thiamine (P<0.05), cobalamin, and combination groups (both Ps<0.001).. Locally injected thiamine had a significant antipruritic effect, cobalamin had an analgesic effect, and their combination had the dual effect with no obvious synergies. This intervention was efficacious, tolerable, and safe for herpetic itching.

Topics: Activities of Daily Living; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Female; Herpes Zoster; Humans; Lidocaine; Male; Middle Aged; Neuralgia; Pain Measurement; Pruritus; Quality of Life; Severity of Illness Index; Thiamine; Time Factors; Treatment Outcome; Vitamin B 12

There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects.. In this randomized, prospective clinical trial, the effects of the vitamin D(3) analog calcipotriol were evaluated against those of a recently developed vitamin B(12) cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography.. There was a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p < 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B(12) cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B(12) preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B(12) cream containing avocado oil as significantly better in comparison with that of calcipotriol.. The results of this clinical trial provide evidence that the recently developed vitamin B(12) cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.

Topics: Adult; Aged; Calcitriol; Dermatologic Agents; Female; Humans; Male; Middle Aged; Ointments; Persea; Phytotherapy; Plant Oils; Prospective Studies; Pruritus; Psoriasis; Severity of Illness Index; Skin; Time Factors; Treatment Outcome; Ultrasonography; Vitamin B 12

Generalized pruritus can often be the primary manifestation of systemic disease.. To determine how frequently generalized pruritus had a systemic etiology in an outpatient population seen in a dermatology department and whether any identifiable patient characteristics meant a systemic explanation of generalized pruritus was more likely.. A prospective controlled study of 55 patients with generalized pruritus and 41 healthy age- and sex-matched control subjects. Clinical data were collected from patients and laboratory parameters investigated in both patients and healthy control subjects to determine the frequency of systemic disease in each group.. Of 55 patients, 12 had a systemic cause of pruritus. Pruritus was the initial symptom of systemic disease in eight of these patients. The underlying diseases included hypothyroidism, chronic lymphocytic leukemia, hepatitis C, hepatitis B, diabetes mellitus, lung cancer, uremia, and iron deficiency anemia. Of these, iron deficiency anemia was the most common cause. Compared with the control group, mean serum hemoglobin, iron, and cyanocobalamin (vitamin B(12)) levels in patients with generalized pruritus were lower. No other patient characteristics were statistically associated with systemic causes of pruritus.. Generalized pruritus was the initial symptom of a systemic disease in 8 of 55 patients presenting to a dermatology outpatient clinic with this complaint. A number of underlying diseases were identified, of which the most common was iron deficiency anemia.

Topics: Adult; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Case-Control Studies; Diabetes Complications; Female; Hemoglobins; Hepatitis, Viral, Human; Humans; Hypothyroidism; Iron; Leukemia, Lymphocytic, Chronic, B-Cell; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Prostatic Neoplasms; Pruritus; Statistics, Nonparametric; Uremia; Vitamin B 12

Topics: Drug Hypersensitivity; Female; Hematinics; Humans; Hydroxocobalamin; Middle Aged; Pruritus; Skin Tests; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anabolic Agents; Female; Humans; Keloid; Middle Aged; Paranoid Disorders; Prednisolone; Pruritus; Vitamin B 12

Topics: Adult; Aged; Alkaline Phosphatase; Blood Platelets; Blood Volume; Bone Marrow; Chlorambucil; Erythrocyte Count; Erythropoietin; Female; Hemoglobins, Abnormal; Hookworm Infections; Humans; Hydrogen-Ion Concentration; Leukocyte Count; Male; Middle Aged; Oxygen; Phosphorus Radioisotopes; Polycythemia; Polycythemia Vera; Pruritus; Riboflavin Deficiency; Uric Acid; Vitamin B 12

Topics: Acute Disease; Adolescent; Adult; Aged; Eosinophils; Feces; Female; Hepatitis A; Humans; Liver; Liver Function Tests; Male; Middle Aged; Organotherapy; Pruritus; Spleen; Tissue Extracts; Vitamin B 12