vitamin-b-12 and Prostatitis

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is reported in the literature ranging from 1 to 14.2%. The aim of the present study was to assess the impact on patient's quality of life and symptoms of Flower pollen extract in association with vitamins (Deprox 500®) in comparison with Serenoa repens 320 mg (Permixon 320 mg® by Pierre Fabre) in patients with CP/CPPS.. All consecutive patients, with a diagnosis of CP/CPPS, referred to our center from January to August 2016, were screened to be enrolled in this single-center, randomized, controlled trial. The main outcome measure was the evaluation of IPSS/NIHCPSI (International Prostatic Symptom Score/NIH-Chronic Prostatitis Symptom Index) score variation and the assessment of the quality of life and symptoms at the end of the therapy. The second outcome measure was the evaluation of the comorbidity role in the CP/CPPS therapy. 63 patients were analyzed; patients were randomized into two groups: 29 patients were treated with Deprox 500® 2 tablets/day for 6 weeks and 34 patients with Serenoa repens 320 mg, 1 tablet/day for 6 weeks.. The mean score variation for IPSS was -12.7 ± 4.3 in the Deprox 500® group and -7.8 ± 4.7 in the Serenoa repens group (p=0.0005) while for NIH-CPSI was -17.3±3.1 in the Deprox 500® group and -13.6±4.8 in the Serenoa repens group (p=0.0016). By accounting only the symptoms part of NIH-CPSI questionnaire, the mean score variation reported was -11.5±2.5 in the Deprox 500® group and -9.02±4.0 in the Serenoa repens group (p=0.009321). Furthermore, analyzing the comorbidity subgroups, in patients with hypertension, the mean IPSS score variation was -14.3±3.2 in the Deprox 500® group and - 9.02±4.0 in the Serenoa repens group.. In conclusion, in patients with CP/CPPS, Deprox 500® improves IPSS and NIH-CPSI scores up to 74.5% and 84.5% respectively. Furthermore, in patients with hypertension, the antioxidant effect of Deprox 500® reduces the mean IPSS score of 82.7%.

Topics: Adult; Aged; Disease Progression; Drug Combinations; Folic Acid; Humans; Hypertension; Male; Middle Aged; Plant Extracts; Prostatitis; Quality of Life; Riboflavin; Serenoa; Surveys and Questionnaires; Thiamine; Treatment Outcome; Vitamin B 12; Vitamin B 6; Young Adult

The therapeutic efficacy of CP/CPPS is not very satisfactory and the impact on young male's quality of life is considerable. The aim of the present study is to evaluate the efficacy of pollen extract associated with vitamins (DEPROX 500®) in order to improve the quality of life of young patients affected by chronic prostatitis type IIIb (CP/CPPS) by pain relieving.. All patients with clinical and instrumental diagnosis of CP/CPPS (class b) underwent DEPROX 500® 2 tablets in a single dose daily for 30 days. Clinical and microbiological analyses were carried out at the enrolment and after 1 month. NIH-CPSI and IPSS questionnaires have been used. The main outcome measure was the improvement of quality of life at the end of the whole study period, evaluated by questionnaires results.. 20 men (mean age 32.8 ± 6.78) were enrolled in this pilot study. The baseline questionnaire mean scores were 25.90 ± 2.1 and 8.01 ± 3.64 for NIH-CPSI and IPSS, respectively. At the follow-up examination (1 month after treatment), 18 out of 20 patients (90.0%) reported an improvement of quality of life, in terms of pain reduction. The questionnaire results after 1 month from treatment were as follows: NIH-CPSI 12.8 ± 2.20, IPSS 7.6 ± 1.58. Statistically significant differences were then reported between the two visits, in terms of NIH-CPSI scores (p<0.001). No statistically significant differences have been reported in terms of IPSS between the two groups. All patients were negative at the Meares-Stamey test evaluation. The compliance to the study protocol was 100%.. The pollen extract associated with vitamins (DEPROX 500®) significantly improved 
total symptoms, pain, and QoL in patients with non-inflammatory CP/CPPS without severe side 
effects.

Topics: Adult; Drug Combinations; Folic Acid; Humans; Male; Phytotherapy; Pilot Projects; Plant Extracts; Pollen; Prostatitis; Riboflavin; Thiamine; Vitamin B 12; Vitamin B 6; Vitamins

Although the relationship between the amount of vitamin B12 and the quality of sperm exists, but results are controversial and require several additional research. The objective of our study was to analyse the amount of vitamin B12 in the sperm samples from patients with chronic prostatitis and varicocele with accompanying asthenozoospermia, and to identify the relationship between the amount of vitamin B12 and asthenozoospermia. The research was carried out of men with chronic prostatitis and varicocele with accompanying asthenozoospermia and infertility at the age of 27±2 years. The material of the investigation was spermoplasm. A chemical microscopic examination of the ejaculate was carried out with a sperm analyzer and with the light microscopy. The amount of vitamin B12 in the spermoplasm was determined by the method of competitive ELISA. It was found that the level of vitamin B12 was 3.6 times lower in patients with chronic prostatitis III B and asthenozoospermia then in the control group. Among patients with varicocele of II and III grade and asthenozoospermia, the level of vitamin B12 was 4.4 times lower than in control group. A positive correlation relationship of average strength was revealed (r=0,683; p=0,001). Additionally, it was revealed that among patients with Chronic prostatitis III B and varicocele of II and III grades with accompanying asthenozoospermia, there was the positive correlation relationship of average strength (r=0,690; p=0,001) between the amount of vitamin B12 and sperm mobility. A decrease in vitamin B12 levels may serve as a marker of reproductive dysfunction in men.. V nauchnoĭ literature imeiutsia dannye, podtverzhdaiushchie vzaimosviaz' kolichestva vitamina B12 i kachestvo spermy, no rezul'taty protivorechivy. Tsel'iu nashego issledovaniia byla kolichestvennaia otsenka vitamina B12 v spermoplazme u patsientov s khronicheskim prostatitom i varikotsele s soputstvuiushcheĭ astenozoospermieĭ i vyiavlenie vozmozhnoĭ vzaimosviazi mezhdu kolichestvom vitamina B12 i astenozoospermieĭ. Ob"ektom issledovaniia sluzhili 90 muzhchiny v vozraste 27±2 goda s diagnozom khronicheskiĭ prostatit i varikotsele s soputstvuiushcheĭ astenozoospermieĭ i besplodiem. Materialom dlia issledovaniia byla spermoplazma. Éiakuliat issledovali na spermoanalizatore i s pomoshch'iu svetovoĭ mikroskopii. Kolichestvo vitamina B12 v spermoplazme opredeliali metodom konkurentnogo IFA. U patsientov s khronicheskim prostatitom III V i astenozoospermieĭ vyiavleno snizhenie vitamina B12 v 3,6 raza po sravneniiu s kontrol'noĭ gruppoĭ. U patsientov s varikotsele II i III stepeni i astenozoospermieĭ vyiavleno snizhenie vitamina B12 v 4,4 raza po sravneniiu s kontrol'noĭ gruppoĭ. Byla vyiavlena polozhitel'naia korreliatsiia sredneĭ stepeni vyrazhennosti (r=0,683; r=0,001) mezhdu podvizhnost'iu spermatozoidov i kolichestvom vitamina B12. U patsientov s khronicheskim prostatitom III V i varikotsele II i III stepeni, soprovozhdaiushchikhsia astenozoospermieĭ, byla vyiavlena polozhitel'naia korreliatsiia sredneĭ stepeni vyrazhennosti (r=0,690; r=0,001) mezhdu podvizhnost'iu spermatozoidov i kolichestvom vitamina B12. Snizhenie urovnia vitamina B12 nizhe v spermoplazme mozhet sluzhit' markerom narusheniia reproduktivnoĭ funktsii u muzhchin.

Topics: Adult; Asthenozoospermia; Humans; Male; Prostatitis; Sperm Motility; Varicocele; Vitamin B 12

Topics: Anemia; Biopsy, Needle; Castration; Cholesterol; Diethylstilbestrol; Estrogens; Folic Acid; Hematuria; Humans; Iron; Lipoproteins; Lymph Nodes; Male; Neoplasm Metastasis; Prostatectomy; Prostatic Neoplasms; Prostatitis; Testosterone; Triglycerides; Uremia; Urination Disorders; Vitamin B 12