vitamin-b-12 and Preleukemia

Topics: Adrenal Cortex Hormones; Aged; Alkaline Phosphatase; Androgens; Antineoplastic Agents; Blood Cell Count; Blood Transfusion; Chromosome Aberrations; Chromosome Disorders; Folic Acid; Humans; Leukocytes; Middle Aged; Muramidase; Myeloproliferative Disorders; Peroxidase; Preleukemia; Prognosis; Pyridoxine; Vitamin B 12

Topics: Anemia, Aplastic; Anemia, Macrocytic; Antineoplastic Agents; Bone Marrow; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Metaplasia; Preleukemia; Prognosis; Syndrome; Vitamin B 12

The facts known today about the occurrence and possible mechanisms of anaemias caused by medicaments are represented in a survey. In this connection toxic haemolytic anaemias, immunohaemolytic anaemias, toxic aplastic anaemias, megaloblastic anaemias, and some other, more rarely occurring types are referred to.

Topics: Alcoholism; Anemia; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Megaloblastic; Anemia, Sideroblastic; Antitubercular Agents; Benzenesulfonates; Bone Marrow; Chloramphenicol; Chromosome Aberrations; Contraceptives, Oral, Hormonal; Folic Acid Antagonists; Gastrointestinal Hemorrhage; Humans; Preleukemia; Purines; Pyrimidines; Vitamin B 12

The clinical course of 42 patients with hemopoietic dysplasia diagnosed during 1974-77 has been studied. The clinical, laboratory and morphological findings at presentation were investigated for prognostic significance. At the time of completion of the study (Aug. 1979), 38% had developed acute leukemia (median survival after diagnosis 5 months) and 45% had died of complications (bleeding and infections) due to severe cytopenia (median survival 6 months). An overall malignant course was observed in patients with low platelet count (less than 80 X 10(9)/l), bleedings and severe myeloid maturation defect in the bone marrow (greater than or equal to 30% myeloblasts and promyelocytes). Increased serum vitamin B12 and presence of myeloblasts, promyelocytes and abnormal "monocytoid' cells in the peripheral blood indicated a leukemic termination.

Topics: Aged; Bone Marrow; Female; Humans; Male; Platelet Count; Preleukemia; Prognosis; Thrombocytopenia; Vitamin B 12

The clinical and laboratory features of the stages in the evolution of acute nonlymphocytic leukemia are reviewed. Based on a retrospective analysis of 34 patients who died with an acute myelomonoblastic leukemia, the "preleukemic syndrome" has been shown to display a clinical picture sufficiently specific to permit its recognition prospectively (i.e., before the development of overt leukemia). The results to date of a variety of prospective studies are reviewed, and the approach(es) to the management of these cases is considered.

Topics: Adrenal Cortex Hormones; Aged; Androgens; Antimetabolites, Antineoplastic; Blood Transfusion; Bone Marrow Cells; Erythrocytes, Abnormal; Folic Acid; Granulocytes; Humans; Male; Megakaryocytes; Middle Aged; Preleukemia; Retrospective Studies; Splenectomy; Vitamin B 12