vitamin-b-12 and Precancerous-Conditions

Pernicious anemia is still a neglected disorder in many medical contexts and is underdiagnosed in many patients. Pernicious anemia is linked to but different from autoimmune gastritis. Pernicious anemia occurs in a later stage of autoimmune atrophic gastritis when gastric intrinsic factor deficiency and consequent vitamin B

Topics: Anemia, Pernicious; Gastritis; Humans; Micronutrients; Precancerous Conditions; Stomach Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins

It is hypothesized that vitamin B. This case-control study based on 3-day duplicated diet samples was conducted in a high-risk area of Huai'an, China. A 100 EPL cases and 100 healthy controls matched by gender, age (± 2 years) and villages were included. Dietary intake of vitamin B. Dietary vitamin B. Excellent transport capability of bio-active vitamin B

Topics: Case-Control Studies; Diet; Female; Humans; Male; Precancerous Conditions; Vitamin B 12; Vitamins

The influence of methylcobalamin (MeCbl) on transplacental effect of N-nitrosoethylurea (NEU) was studied in organ cultures of embryonic tissue of DBA/2 mice by the histoautoradiography (3H TdR). A combined transplacental treatment of pregnant mice with MeCbl and NEU produced a 3.3-fold increase in the frequency of focal hyperplastic growth of epithelium as compared to the effect of NEU alone. Under such conditions the modifying effect of methylcobalamin, coenzyme of methionine synthetase, was probably due to an increase in the proliferative activity of epithelial cells.

Topics: Animals; Cocarcinogenesis; Ethylnitrosourea; Female; Fetal Diseases; Kidney Neoplasms; Maternal-Fetal Exchange; Mice; Organ Culture Techniques; Precancerous Conditions; Pregnancy; Vitamin B 12

Topics: Adult; Age Factors; Duodenal Ulcer; Gastric Mucosa; Gastritis, Atrophic; Gastroenterostomy; Humans; Intestinal Polyps; Iron; Male; Middle Aged; Postoperative Complications; Precancerous Conditions; Stomach Neoplasms; Time Factors; Vitamin B 12

A review has been carried out of patients diagnosed as having coeliac disease some years previously and subsequently lost to follow-up. Most were unaware of the need for continuing treatment and had returned to a normal diet. The resulting morbidity was slight, although one patient had died of a small-bowel lymphoma. If untreated coeliac disease is indeed a pre-malignant condition, then it is suggested that there must be a large population at risk, with no motivation to return to treatment other than the risk of malignancy itself.

Topics: Adolescent; Adult; Anemia; Blood Proteins; Body Constitution; Celiac Disease; Child; Female; Folic Acid; Follow-Up Studies; Glutens; Hemoglobins; Humans; Intestinal Neoplasms; Iron; Jejunum; Lymphoma; Magnesium; Male; Precancerous Conditions; Vitamin B 12

Topics: Adenoma, Islet Cell; Bicarbonates; Celiac Disease; Diarrhea; Duodenum; Feces; Female; Gastric Juice; Humans; Hyperplasia; Hypokalemia; Intestinal Secretions; Malabsorption Syndromes; Middle Aged; Pancreas; Pancreatic Neoplasms; Pancreatitis; Potassium; Precancerous Conditions; Vitamin B 12

The prevalence of circulating antibodies to gastric intrinsic factor and parietal cells was examined in 60 patients with histologically proven gastric carcinoma and was found not to differ from the prevalence of these antibodies in control subjects of similar age and sex distribution.Amongst the 60 patients with gastric carcinoma seven were thought to have actual or potential pernicious anaemia. The absence of an increased prevalence of antigastric antibodies in gastric carcinoma indicates that gastritis itself, whether autoimmune or not, is the likely common denominator underlying the predisposition to gastric carcinoma in both pernicious anaemia and chronic atrophic gastritis.

Topics: Adolescent; Adult; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Child; Female; Gastritis; Humans; Intrinsic Factor; Male; Middle Aged; Precancerous Conditions; Stomach; Stomach Neoplasms; Vitamin B 12

Gastric carcinoma was detected nine, 10, 18, and 21 years after the biopsy diagnosis of atrophic gastritis in four patients of a group of 40. The gastritis was presumed to be of the simple type. Tests of vitamin B(12) absorption in three patients gave normal results, no gastric autoantibodies were detected in the two patients tested, in all patients histological examination of the gastrectomy specimens revealed a multifocal gastritis differing from the diffuse gastritis of pernicious anaemia and in three patients the gastritis affected the antrum, which is unusual in pernicious anaemia. The 10% incidence of gastric carcinoma in 40 patients with simple atrophic gastritis followed for a mean period of 15 years is equivalent to that previously described in pernicious anaemia. However, in view of the relative incidence of atrophic gastritis with and without pernicious anaemia in the general adult population, it emerges that atrophic gastritis without pernicious anaemia is numerically the more important precursor of gastric carcinoma.

Topics: Adult; Anemia, Pernicious; Atrophy; Autoantibodies; Biopsy; Female; Follow-Up Studies; Gastrectomy; Gastritis; Humans; Intestinal Absorption; Male; Middle Aged; Precancerous Conditions; Pylorus; Stomach Neoplasms; Vitamin B 12

Topics: Aged; Anemia, Sideroblastic; Ascorbic Acid; Autopsy; Blood Cell Count; Blood Transfusion; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Erythrocytes; Erythropoiesis; Folic Acid; Follow-Up Studies; Humans; Hyperplasia; Iron; Leukemia, Myeloid; Male; Middle Aged; Monocytes; Muramidase; Precancerous Conditions; Pyridoxine; Vitamin B 12