vitamin-b-12 and Nasopharyngeal-Neoplasms

To explore the effect of quadruple fluid aerosol inhalation on oral mucositis induced by radiotherapy in nasopharyngeal carcinoma (NPC) and its mechanism.. One hundred and twenty NPC patients were divided into a treatment group (n=60) and a control group (n=60). Radiation therapy was administered conventionally over 7 weeks with 2.0 Gy daily fractions for 5 days each week at the 70 Gy. Patients in the control group accepted oral care conventionally, and patients in the treatment group used quadruple fluids aerosol inhalation before the radiotherapy. The saliva volume was measured by a nurse twice a week and the concentration of epidemal growth factor (EGF) was examined by ELISA.. The number of patients with mucositis in the treatment group was significantly fewer than that in the control group when the total doses were up to 30 Gy and 60 Gy (P<0.05). The concentration of EGF in the control group significantly decreased when total doses were up to 30 Gy and 60 Gy (P<0.01). The concentration of EGF in the treatment group was not significantly different compared with pre-radiotherapy when the total doses were up to 30 Gy, but when total doses were up to 60 Gy, the concentration of EGF in the treatment group obviously decreased compared with that of pre-radiotherapy.. The quadruple fluid aerosol inhalation is effective to reduce oral mucositis resulted from radiotherapy in NPC patients, which is related to the delay of the EGF decrease in the saliva.

Topics: Administration, Inhalation; Adult; Aerosols; Aged; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Female; Gentamicins; Humans; Male; Menthol; Middle Aged; Nasopharyngeal Neoplasms; Procaine; Radiotherapy; Saliva; Stomatitis; Treatment Outcome; Vitamin B 12; Vitamins

To evaluate the therapeutic effect of inhalation of vitamin B12 mixed solution in treating acute radiation-induced mucosal injury.. Totally 122 patients with acute radiation-induced mucosal injury resulting from radiotherapy were divided into two equal groups and received vitamin B12 mixed solution inhalation and gentamycin sulfate mixed solution inhalation, respectively.. The patients receiving inhalation of vitamin B12 mixed solution showed favorable response to the treatment and the mucosal injury was alleviated as manifested by relieved pains, improved appetite and lessened body weight loss, which allowed uninterrupted administration of radiotherapy. In patients treated with inhalation of gentamycin sulfate mixed solution, by contrast, the mucosal injury was serious and in 8 patients radiotherapy had to be suspended for acute radiation-induced mucosal injury.. Vitamin B12 mixed solution inhalation can be an effective treatment for acute radiation-induced mucosal injury.

Topics: Administration, Inhalation; Adult; Female; Humans; Male; Middle Aged; Mucous Membrane; Nasopharyngeal Neoplasms; Radiation Injuries; Vitamin B 12

Many studies have suggested that folate-related one-carbon metabolism-related nutrients may play a role in certain cancer risks, but few studies have assessed their associations with the risk for nasopharyngeal carcinoma (NPC). In this study, we investigated the association between four folate-related one-carbon metabolism-related nutrients (folate, vitamin B6, vitamin B12 and methionine) and NPC risk in Chinese adults. A total of 600 patients newly diagnosed (within 3 months) with NPC were individually matched with 600 hospital-based controls by age, sex and household type (urban v. rural). Folate, vitamin B6, vitamin B12 and methionine intakes were measured using a validated seventy-eight-item FFQ. A higher dietary folate or vitamin B6 intake was associated with a lower NPC risk after adjusting for potential confounders. The adjusted OR of NPC for quartiles 2-4 (v. 1) were 0·66 (95% CI 0·48, 0·91), 0·52 (95% CI 0·37, 0·74) and 0·34 (95% CI 0·23, 0·50) (P(trend)<0·001) for folate and 0·72 (95% CI 0·52, 1·00), 0·55 (95% CI 0·39, 0·78) and 0·44 (95% CI 0·30, 0·63) (P(trend)<0·001) for vitamin B6. No significant association with NPC risk was observed for dietary vitamin B12 or methionine intake. The risk for NPC with dietary folate intake was more evident in the participants who were not exposed to toxic substances than in those who were exposed (P(interaction)=0·014). This study suggests that dietary folate and vitamin B6 may be protective for NPC in a high-risk population.

Topics: Adult; Carcinoma; Case-Control Studies; China; Diet; Female; Folic Acid; Humans; Male; Methionine; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Nasopharynx; Odds Ratio; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency