vitamin-b-12 and Mesenteric-Vascular-Occlusion

Acute mesenteric venous thrombosis (AMVT) was first reported by Fagge and was recognised as a distinct clinical entity by Warreen in 1935. However, its pathogenesis is still unclear. Elevated plasma levels of homocysteine (Hcy) are associated with an increased risk of deep vein thrombosis. This case-control study examines the potential association among hyperhomocysteinaemia (hyper-Hcy), low serum folate and vitamin B(12) levels and the common C677T mutation of the MTHFR gene in patients with AMVT.. Sixty-three patients with AMVT and 75 sex- and age-matched healthy controls were recruited, and their plasma Hcy, folate and vitamin B(12) levels were measured by high performance liquid chromatography (HPLC) and immunological assays. The polymorphism of MTHFR C677T was detected by PCR-RFLP.. The mean plasma Hcy levels were significantly higher in patients with AVMT compared with controls (23.5 standard deviation (S.D.) 8.8 vs. 12.6+/-6.6micromoll(-1), P<0.01). The fasting Hcy correlated negatively with folate (AMVT: r=-0.42, P<0.01;. r=-0.40, P<0.01). The frequency of homozygous (TT) genotype in MTHFR C677T mutation was significantly higher in patients with AMVT than that in control subjects (33% vs. 17%; chi square (chi(2))=6.31, P<0.05; odds ratio (OR)=2.80; 95% confidence interval (CI): 1.25-6.25). Compared with the control subjects, the mean serum vitamin B(12) levels were lower in patients, but it was not statistically significant (365+/-88pmoll(-1) vs. 408+/-108pmoll(-1), P>0.05).. Hyper-Hcy and low serum folate levels were associated with an increased risk of AMVT. The homozygous (TT) genotype of MTHFR gene mutation may be a crucial hereditary risk factor in the development of AMVT for a Chinese population.

Topics: Acute Disease; Adult; Aged; Asian People; Biomarkers; Case-Control Studies; Chi-Square Distribution; China; Chromatography, High Pressure Liquid; Down-Regulation; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Immunoassay; Male; Mesenteric Vascular Occlusion; Mesenteric Veins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Risk Assessment; Risk Factors; Venous Thrombosis; Vitamin B 12; Young Adult

During the period from 1971 to 1981 in 145 patients (108 adults and 37 children) partial resections of the intestine were practiced (in the surgical clinic of the Friedrich-Schiller-University, Jena). Fatality on the whole was about 25%. The surgical intervention with an extensive resection (more than 150 cm) was well tolerated by seven among 13 patients. Even in cases of shorter resections disturbances of resorption could be found especially for carbohydrates and vitamin B 12. Control examinations are necessary and therapeutic consequences have to be drawn.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dietary Fats; Female; Humans; Hypokalemia; Infant, Newborn; Intestinal Obstruction; Intestine, Small; Malabsorption Syndromes; Male; Mesenteric Vascular Occlusion; Middle Aged; Peptic Ulcer; Postoperative Complications; Vitamin B 12; Xylose

Topics: Bile Acids and Salts; Celiac Disease; Cholelithiasis; Crohn Disease; Diarrhea; Humans; Ileocecal Valve; Intestinal Absorption; Intestine, Small; Mesenteric Arteries; Mesenteric Vascular Occlusion; Mesenteric Veins; Thrombosis; Vitamin B 12

Topics: Adolescent; Adult; Biopsy; Cecum; Celiac Disease; Colon; Female; Hemoglobinometry; Humans; Intestinal Mucosa; Lupus Erythematosus, Systemic; Malabsorption Syndromes; Male; Mesenteric Vascular Occlusion; Middle Aged; Prednisone; Radiography; Vitamin B 12; Xylose

Topics: Age Factors; Aged; Blood Proteins; Body Weight; Calcium; Carbohydrate Metabolism; Codeine; Fats; Gastric Juice; Humans; Infusions, Parenteral; Intestinal Absorption; Intestine, Small; Magnesium; Magnesium Oxide; Male; Mesenteric Vascular Occlusion; Minerals; Proteins; Serum Albumin; Vitamin B 12; Vitamins

Topics: Female; Humans; Intestinal Absorption; Intestine, Small; Mesenteric Vascular Occlusion; Middle Aged; Vitamin B 12