vitamin-b-12 and Meniere-Disease

The records of 47 patients with Ménière's syndrome were analyzed in a retrospective computerized study to determine the effect of different medical regimens on the long term course of hearing loss. Four treatment groups, including histamine (subcutaneous), other vasodilators (oral), vitamins, and untreated controls were examined. Results suggest that there was no statistically significant difference among the four groups in the rates or absolute level of hearing loss or SRT despite different therapeutic regimens. The ability of these agents to conserve hearing in patients with Ménière's syndrome remains unproven on the basis of clinical and laboratory evidence.

Topics: Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Hearing; Hearing Disorders; Histamine; Humans; Male; Meniere Disease; Middle Aged; Retrospective Studies; Thiamine; Vasodilator Agents; Vitamin B 12

Recently several investigations have been reported suggesting that the cause of endolymphatic hydrops might be an immunologic disorder of the endolymphatic space, including the endolymphatic sac. As the first choice in a conservative treatment by medication, the authors have used a combination of prednisolone and furosemide per os, which is rather safe and effective for hydrops patients in a subacute stage. However, some patients do not respond to this treatment or gradually become immune to this medication. With these patients, we have tried an intravenous administration of immunoglobulin G with methyl B12, expecting a curative effect on immunologic deficiency in the endolymphatic space. Compared with a group of patients without this treatment, the group receiving it showed rather good scores in hearing improvement; however, vertigo and tinnitus remained almost unchanged.

Topics: Adult; Aged; Combined Modality Therapy; Drug Resistance; Edema; Endolymphatic Sac; Female; Furosemide; Hearing Loss; Humans; Immunoglobulin G; Injections, Intravenous; Labyrinth Diseases; Male; Meniere Disease; Middle Aged; Prednisolone; Vitamin B 12

Topics: Adrenal Cortex Hormones; Adult; Ascorbic Acid; Carbohydrate Metabolism; Diet Therapy; Estrogens; Female; Glucose; Glucose Tolerance Test; Gonadal Steroid Hormones; Humans; Male; Meniere Disease; Middle Aged; Progesterone; Pyridoxine; Testosterone; Vitamin B 12

Topics: Ascorbic Acid; Choline; Deafness; Flavanones; Flavonoids; Glycosides; Inositol; Meniere Disease; Methionine; Niacin; Nicotinic Acids; Pantothenic Acid; Pyridoxine; Riboflavin; Thiamine; Vitamin B 12