vitamin-b-12 and Lymphoma

vitamin-b-12 has been researched along with Lymphoma* in 20 studies

Reviews

3 review(s) available for vitamin-b-12 and Lymphoma

ArticleYear
Newer developments in nuclear medicine applicable to hematology.
    Progress in hematology, 1977, Volume: 10

    Topics: Blood Platelets; Bone Marrow; Clinical Competence; Erythrocytes; Ferritins; Gallium Radioisotopes; Granulocytes; Hematology; Hodgkin Disease; Humans; Isotope Labeling; Lymphoma; Nuclear Medicine; Radioactive Tracers; Radioligand Assay; Radionuclide Imaging; Spleen; Vitamin B 12

1977
Tropical enteropathy.
    Gastroenterology, 1973, Volume: 64, Issue:4

    Topics: Anti-Bacterial Agents; Child; Fats; Folic Acid; Humans; Intestinal Absorption; Intestinal Neoplasms; Intestine, Small; Intestines; Jejunum; Lymphoma; Remission, Spontaneous; Sprue, Tropical; Vitamin B 12; Water

1973
Tropical sprue.
    British medical bulletin, 1972, Volume: 28, Issue:1

    Topics: Age Factors; Animals; Child; Child, Preschool; Diarrhea; Disease Outbreaks; Feces; Female; Folic Acid; Humans; Intestinal Absorption; Intestinal Mucosa; Intestinal Neoplasms; Lipid Metabolism; Lymphoma; Male; Sprue, Tropical; Tritium; Vitamin B 12

1972

Other Studies

17 other study(ies) available for vitamin-b-12 and Lymphoma

ArticleYear
Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome.
    Blood, 2010, Jun-24, Volume: 115, Issue:25

    Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), whereas some cases have been noted to have a somatic mutation of FAS primarily in their DNT cells. We sought to determine the proportion of patients with somatic FAS mutations among a group of our ALPS patients with no detectable germline mutation and to further characterize them. We found more than one-third (12 of 31) of the patients tested had somatic FAS mutations, primarily involving the intracellular domain of FAS resulting in loss of normal FAS signaling. Similar to ALPS type Ia patients, the somatic ALPS patients had increased DNT cell numbers and elevated levels of serum vitamin B(12), interleukin-10, and sFAS-L. These data support testing for somatic FAS mutations in DNT cells from ALPS patients with no detectable germline mutation and a similar clinical and laboratory phenotype to that of ALPS type Ia. These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children.

    Topics: Adult; Autoimmune Lymphoproliferative Syndrome; Child; Child, Preschool; Fas Ligand Protein; fas Receptor; Female; Humans; Interleukin-10; Lymphoma; Male; Mutation; Protein Structure, Tertiary; Risk Factors; Vitamin B 12

2010
Prevalence and prognostic impact of hypocobalaminemia in dogs with lymphoma.
    Journal of the American Veterinary Medical Association, 2009, Dec-15, Volume: 235, Issue:12

    To determine the prevalence of hypocobalaminemia in dogs with multicentric lymphoma and to investigate any relationship between serum cobalamin concentration and disease outcome.. Cohort study.. 58 dogs with multicentric lymphoma.. Serum cobalamin concentrations were measured in 58 dogs with multicentric lymphoma. Clinical signs, stage, and immunophenotype for dogs with hypocobalaminemia were compared with those for dogs with serum cobalamin concentrations above the lower end of the reference range. Survival times for dogs undergoing a cyclic multidrug chemotherapy protocol (n = 53) were similarly compared. Serum cobalamin concentrations for treated dogs that died or were euthanized before day 60 were compared with those of dogs still alive at day 60.. Serum cobalamin concentrations ranged from < 150 to 1,813 ng/L, with a median concentration of 401 ng/L. Nine of the 58 (16%) dogs had hypocobalaminemia (serum cobalamin concentration < 252 ng/L). Three of 9 dogs with hypocobalaminemia survived to at least day 60, compared with 40 of 44 (91%) dogs without hypocobalaminemia (serum cobalamin concentration >or= 252 ng/L). Ten (10/53 [19%]) dogs undergoing a cyclic multidrug chemotherapy protocol died before day 60, and the median serum cobalamin concentration for these dogs (232 ng/L) was significantly lower than for those still alive at the end point of the study (556 ng/L).. Hypocobalaminemia was relatively uncommon in this population of dogs with multicentric lymphoma, but was associated with a poor outcome. Serum cobalamin concentrations may provide prognostic information in dogs with multicentric lymphoma.

    Topics: Animals; Antineoplastic Agents; Dog Diseases; Dogs; Female; Lymphoma; Male; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency

2009
Antibodies to transcobalamin II block in vitro proliferation of leukemic cells.
    Blood, 1997, Jan-01, Volume: 89, Issue:1

    The plasma protein transcobalamin II (TCII) binds and delivers cobalamin (Cbl; vitamin B12) to all cells, which internalize the TCII/Cbl complex by receptor-mediated endocytosis. Congenital deficiency of TCII results in intracellular Cbl deficiency, one effect of which is to disrupt DNA synthesis, leading to megaloblastic anemia. We report here an in vitro culture system in which cell growth is dependent on delivery of Cbl to cells by TCII. Recombinant human holo-TCII was shown to support in dose-dependent manner the growth of the human erythroleukemic cell line K562 and the murine lymphoma cell line BW5147. Free Cbl also supported cell growth; however, at 100- to 1,000-fold higher concentrations than those effective in the presence of apo-TCII. To determine if cellular depletion of Cbl could be achieved by interfering with interactions between TCII/Cbl and its cell-surface receptor, several monoclonal antibodies raised against human TCII were studied. Three antibodies, found to compete for the same binding site on TCII, proved to be effective inhibitors of TCII/Cbl-dependent cell growth. Our results suggest that monoclonal anti-TCII antibodies that block the function of this protein may prove useful in antitumor therapies.

    Topics: Antibodies, Monoclonal; Apoptosis; Cell Division; Folic Acid; Growth Inhibitors; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Neoplastic Stem Cells; Transcobalamins; Tumor Cells, Cultured; Vitamin B 12

1997
Cytotoxic activity of cobalamin in cultured malignant and nonmalignant cells.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 1990, Volume: 58, Issue:5

    The cytotoxic effect of cobalamin (vitamin B12) on the growth of malignant and nonmalignant cell lines in culture has been examined. Among the four cobalamins studied, 5'-deoxyadenosylcobalamin, an enzymatically active derivative, was an effective cytotoxic agent. The data indicated that adenosylcobalamin seemed to act selectively on fast-growing malignant cells. Methylcobalamin was also effective at elevated concentrations. Cyanocobalamin was not toxic to all cell lines studied. Hydroxocobalamin at very high concentrations was able to slightly decrease growth of certain cell lines. The results support the hypothesis that the cytotoxic effect of cobalamin was associated with the metabolic activities of this vitamin at the cellular level. Also, cobalamin may be a potential antitumor agent.

    Topics: Animals; Blood Cells; Cell Transformation, Neoplastic; Cells, Cultured; Connective Tissue; Connective Tissue Cells; Fibrosarcoma; Humans; Leukemia L1210; Lung; Lymphoma; Male; Mice; Tumor Cells, Cultured; Vitamin B 12

1990
The influence of radiotherapy and chemotherapy on the vitamin status of cancer patients.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1985, Volume: 55, Issue:4

    The influence of external abdominal irradiation and cytostatic therapy on the vitamin status was studied in patients with cancer of the uterus, bladder or prostate and in patients with malignant lymphoma. It was found that the vitamin status of these patients at the beginning of therapy in general was adequate, though vitamin A and vitamin D levels were reduced. During radiotherapy decreases of vitamin E, vitamin C, vitamin B12 and folic acid levels were observed. Chemotherapy caused a decrease of the folic acid levels after a few months. No clinical symptoms of vitamin deficiency were observed.

    Topics: Ascorbic Acid; Calcifediol; Female; Humans; Lymphoma; Male; Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Vitamin A; Vitamin B 12; Vitamin E; Vitamins

1985
Neglected coeliac disease.
    Lancet (London, England), 1975, Jan-25, Volume: 1, Issue:7900

    A review has been carried out of patients diagnosed as having coeliac disease some years previously and subsequently lost to follow-up. Most were unaware of the need for continuing treatment and had returned to a normal diet. The resulting morbidity was slight, although one patient had died of a small-bowel lymphoma. If untreated coeliac disease is indeed a pre-malignant condition, then it is suggested that there must be a large population at risk, with no motivation to return to treatment other than the risk of malignancy itself.

    Topics: Adolescent; Adult; Anemia; Blood Proteins; Body Constitution; Celiac Disease; Child; Female; Folic Acid; Follow-Up Studies; Glutens; Hemoglobins; Humans; Intestinal Neoplasms; Iron; Jejunum; Lymphoma; Magnesium; Male; Precancerous Conditions; Vitamin B 12

1975
Vitamin B 12-binding protein abnormality in subjects without myeloproliferative disease. I. Elevated serum vitamin B 12-binding capacity levels in patients with leucocytosis.
    British journal of haematology, 1972, Volume: 22, Issue:1

    Topics: Adult; Aged; Alpha-Globulins; Beta-Globulins; Blood Proteins; Child, Preschool; Chronic Disease; Female; Fever of Unknown Origin; Hodgkin Disease; Humans; Infections; Leukocyte Count; Leukocytosis; Liver Neoplasms; Lymphoma; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Protein Binding; Splenectomy; Vitamin B 12

1972
Serum vitamin B 12 and vitamin B 12 binding capacity in chronic myelogenous leukemia and other disorders.
    The American journal of the medical sciences, 1972, Volume: 263, Issue:6

    Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Blood Proteins; Female; Hematologic Diseases; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Liver Cirrhosis; Lupus Erythematosus, Systemic; Lymphoma; Male; Multiple Myeloma; Neoplasms; Polycythemia; Primary Myelofibrosis; Protein Binding; Uremia; Vitamin B 12

1972
Gastric secretory and serologic studies on patients with neoplastic and immunologic disorders.
    Archives of internal medicine, 1971, Volume: 128, Issue:5

    Topics: Adult; Anemia, Pernicious; Antibody Formation; Arthritis, Rheumatoid; Autoantibodies; Female; Fluorescent Antibody Technique; Folic Acid; Gastric Juice; Hemagglutination Tests; Hodgkin Disease; Humans; Immunodiffusion; Intrinsic Factor; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Pyrazoles; Radioimmunoassay; Vitamin B 12

1971
Gastro-intestinal function after abdominal cobalt irradiation.
    Acta radiologica: therapy, physics, biology, 1968, Volume: 7, Issue:6

    Topics: Abdominal Neoplasms; Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma; Child; Cobalt Isotopes; Female; Gastric Juice; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Hodgkin Disease; Humans; Intestinal Mucosa; Iodine Isotopes; Leiomyosarcoma; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Male; Mesothelioma; Methods; Middle Aged; Neuroblastoma; Pancreatic Neoplasms; Povidone; Radiation Effects; Radioisotope Teletherapy; Splenic Neoplasms; Time Factors; Triolein; Vitamin B 12

1968
[Hematological diseases (including blood transfusion as a therapy)].
    Naika. Internal medicine, 1968, Volume: 22, Issue:2

    Topics: Blood Platelets; Blood Transfusion; Hematologic Diseases; Hemorrhage; Humans; Iatrogenic Disease; Leukemia; Lymphoma; Thalassemia; Vitamin B 12

1968
Excretion of formiminoglutamic acid in reticulosis and carcinoma.
    Lancet (London, England), 1966, Feb-26, Volume: 1, Issue:7435

    Topics: Anemia, Macrocytic; Blood Chemical Analysis; FIGLU Test; Folic Acid; Humans; Leukemia; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms; Urine; Vitamin B 12

1966
VALUE OF DETECTION OF FORMIMINOGLUTAMIC ACID IN URINE FOR THE DIAGNOSIS OF MALABSORPTION STATES.
    British medical journal, 1965, Apr-17, Volume: 1, Issue:5441

    Topics: Bile Duct Neoplasms; Carbohydrate Metabolism; Celiac Disease; Crohn Disease; Diagnosis; Electrophoresis; Enteritis; Fatty Acids; FIGLU Test; Fluids and Secretions; Folic Acid; Formiminoglutamic Acid; Histidine; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Malabsorption Syndromes; Sprue, Tropical; Urine; Vitamin B 12; Xylose

1965
Serum folate and serum vitamin B12 in patients with malignant hematologie diseases.
    Cancer research, 1965, Volume: 25, Issue:11

    Topics: Blood; Folic Acid; Hodgkin Disease; Humans; In Vitro Techniques; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Vitamin B 12

1965
[THE CLINICAL VALUE OF THE FORMIMINOGLUTAMIC ACID (FIGLU) TEST].
    Nederlands tijdschrift voor geneeskunde, 1964, Mar-07, Volume: 108

    Topics: Anemia; Anemia, Hemolytic; Anemia, Macrocytic; Anemia, Pernicious; Anticonvulsants; Blood; Celiac Disease; Clinical Laboratory Techniques; Epilepsy; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Glutamates; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Urine; Vitamin B 12; Vitamin B Deficiency

1964
INTRINSIC FACTOR DEFICIENCY IN MALIGNANT NEOPLASIA OF THE STOMACH.
    Cancer research, 1963, Volume: 23

    Topics: Adenocarcinoma; Anemia; Anemia, Pernicious; Biological Assay; Blood; Cobalt Isotopes; Gastrectomy; Gastric Acidity Determination; Geriatrics; Histamine; Humans; Intrinsic Factor; Lactobacillus; Liver; Lymphoma; Schilling Test; Stomach Neoplasms; Urine; Vitamin B 12

1963
Serum vitamin B12 in leukemias and malignant lymphomas.
    Blood, 1957, Volume: 12, Issue:9

    Topics: Hematinics; Humans; Leukemia; Lymphoma; Vitamin B 12

1957