vitamin-b-12 and Kwashiorkor

Topics: Abetalipoproteinemia; Adult; Anemia; Anemia, Macrocytic; Animals; Ascorbic Acid; Bone Marrow; Deficiency Diseases; Dietary Fats; DNA Replication; Erythropoiesis; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Iron; Kwashiorkor; RNA; Salmonidae; Selenium; Swine; Vitamin B 12; Vitamin E; Vitamin E Deficiency

Topics: Age Factors; Child, Preschool; Female; Humans; Infant; Kwashiorkor; Male; Mauritania; Nutritional Status; Protein-Energy Malnutrition; Vitamin B 12; Weaning

A group of 39 Nigerian infants and pre-school children with protein-energy malnutrition (PEM) have been studied. Red cell folate levels were within the range observed in 19 age-matched healthy Nigerian children. Serum vitamin B12 levels were either normal or raised. Deoxyuridine (dU) suppression tests were performed on the bone marrow cells of 30 of the patients and were abnormal in 13. It is proposed that the abnormal dU-suppressed values were not caused by vitamin B12 or folate deficiency and were probably a consequence of the protein deficiency. A few megaloblasts and several giant metamyelocytes were found in four of the cases of PEM; the remaining 35 cases had normoblastic erythropoiesis, sometimes with small to moderate numbers of giant metamyelocytes. All four marrow samples containing megaloblasts gave abnormal dU-suppressed values. However, in the marrows showing normoblastic erythropoiesis there was no correlation between the presence or absence of giant metamyelocytes and the dU-suppressed value.

Topics: Bone Marrow; Child, Preschool; Deoxyuridine; DNA; Erythrocytes; Erythropoiesis; Folic Acid; Humans; Infant; Kwashiorkor; Protein-Energy Malnutrition; Thymidine; Vitamin B 12

Vitamin B-12 and total vitamin B-12-binding capacity (TBBC) have been determined by a radio-saturation assay in the blood of a large group of patients suffering from marasmic kwashiorkor on admission, and during their whole re-feeding. The results have been compared with values obtained in control children of the same ethnic group and with normal children living in Belgium. Vitamin B-12 levels are high on admission and only normalize during the second month of re-feeding. TBBC is normal on admission but significantly increases during re-feeding.

Topics: Black People; Child; Child, Preschool; Diet Therapy; Humans; Infant; Kwashiorkor; Protein Binding; Radioligand Assay; Time Factors; Vitamin B 12; White People

Topics: Anemia, Macrocytic; Blood Proteins; Bone Marrow; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Infant Nutrition Disorders; Kwashiorkor; Male; Myelography; Protein-Energy Malnutrition; Vitamin B 12

Topics: Anemia, Macrocytic; Blood Proteins; Bone Marrow Examination; Child Nutritional Physiological Phenomena; Child, Preschool; Erythrocyte Count; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemoglobins; Humans; Infant; Infant Food; Infant Nutritional Physiological Phenomena; Kwashiorkor; Neutrophils; Nutrition Disorders; Nutritional Requirements; Protein Deficiency; Reticulocytes; Serum Albumin; Vitamin B 12; Vitamin E

Topics: Anti-Infective Agents; Blood Platelets; Child, Preschool; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Folic Acid Antagonists; Hemoglobins; Histidine; Humans; Infant; Kwashiorkor; Male; Nutrition Disorders; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections; Vitamin B 12

Topics: Anemia; Blood Volume; Bone Marrow Examination; Child, Preschool; Folic Acid; Humans; Infant; Iron; Kwashiorkor; Vitamin B 12

Topics: Adult; Alpha-Globulins; Animals; Beta-Globulins; Child, Preschool; Cobalt Isotopes; Ethnicity; Humans; In Vitro Techniques; Infant; Kwashiorkor; Leukemia, Myeloid; Liver; Protein Binding; Rats; Vitamin B 12

Topics: Anemia; Anemia, Hypochromic; Bone Marrow Cells; Bone Marrow Examination; Child, Preschool; Deficiency Diseases; Dietary Proteins; Egypt; Erythrocytes, Abnormal; Erythropoiesis; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Infant; Iron; Iron-Dextran Complex; Kwashiorkor; Nutrition Disorders; Protein Deficiency; Reticulocytes; Vitamin B 12; Vitamin E

Topics: Anemia, Macrocytic; Bone Marrow Diseases; Child, Preschool; Folic Acid; Hemoglobins; Humans; India; Infant; Iron; Kwashiorkor; Seasons; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Avitaminosis; Blood Cell Count; Bone Marrow Examination; Child; FIGLU Test; Folic Acid; Folic Acid Deficiency; Glutamates; Glutamic Acid; Histidine; Humans; Imidazoles; Kwashiorkor; Metabolism; Urine; Urocanic Acid; Vitamin B 12

Topics: Anemia; Anemia, Hypochromic; Blood Cell Count; Blood Proteins; Bone Marrow Cells; Child; Diagnosis; Diet; Diet Therapy; Dietary Proteins; Drug Therapy; FIGLU Test; Folic Acid; Hemoglobinometry; Humans; Infant; Kwashiorkor; Proteins; Uganda; Vitamin B 12

Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Blood; Blood Cell Count; Bone Marrow Examination; Child; Egypt; Hematocrit; Hemoglobins; Humans; Infant; Kwashiorkor; Protein Deficiency; Vitamin B 12; Vitamin E

Topics: Anemia, Hemolytic; Anemia, Hypochromic; Blood; Blood Proteins; Child, Preschool; Chromium Isotopes; Erythrocyte Count; Hematocrit; Hemoglobins; Humans; Infant; Iron; Kwashiorkor; Lebanon; Vitamin B 12; Vitamin E; Vitamin E Deficiency

Topics: Absorption; Anemia; Anemia, Macrocytic; Animals; Celiac Disease; Cobalt Isotopes; Gastric Juice; Haplorhini; Ileum; India; Kwashiorkor; Macaca mulatta; Protein Deficiency; Research; Sprue, Tropical; Vitamin B 12

Topics: Animals; Biomedical Research; Blood; Bone Marrow Cells; Child; Chloramphenicol; Diet; Erythroblasts; Erythrocytes; Folic Acid; Haplorhini; Hematinics; Humans; Kwashiorkor; Nutrition Disorders; Papio; Phenylalanine; Protein-Energy Malnutrition; Proteins; Research; Riboflavin; Riboflavin Deficiency; Vitamin B 12

Topics: Blood Chemical Analysis; Deficiency Diseases; Humans; Infant; Infant Nutritional Physiological Phenomena; Kwashiorkor; Pellagra; Vitamin B 12; Vitamin B Complex

Topics: Anemia; Anemia, Megaloblastic; Humans; Infant; Infant Nutrition Disorders; Kwashiorkor; Protein-Energy Malnutrition; Vitamin B 12

Topics: Child; Humans; Infant; Kwashiorkor; Nutrition Disorders; Protein-Energy Malnutrition; Vitamin B 12