vitamin-b-12 and Intracranial-Aneurysm

Pregnancy should not greatly alter the anaesthetic management of a patient with intracranial aneurysms. Controlled hypotension is the method of choice for meeting surgical requirements. Primary attention to the mother with judicious use of sodium nitroprusside is unlikely to compromise the foetus. Sodium nitroprusside is not teratogenic in animal experiments. At present, the biochemical consequences for the foetus of prolonged nitrous oxide anaesthesia are not clear. Present data would support folinic acid administration.

Topics: Anesthesia, Obstetrical; Animals; Female; Ferricyanides; Fetal Hypoxia; Humans; Hypotension, Controlled; Infant, Newborn; Intracranial Aneurysm; Nitroprusside; Pregnancy; Pregnancy Complications, Cardiovascular; Sheep; Vitamin B 12

This research aims to evaluate the effect of mecobalamin treatment on the recovery of patients with posterior communicating artery aneurysm inducing oculomotor nerve palsy after embolization.. A total of 56 patients with oculomotor nerve palsy (ONP) attributed to posterior communicating artery (PcomA), were admitted and treated in the Neurology Department of Hubei College of Medicine affiliated to Xiangyan Hospital from July 2007 to January 2013, and 55 of them were followed up as well. Among them 27 patients were given embolization treatment and 28 received embolization + mecobalamin treatment. The recovery condition of ONP were followed and compared one year after the treatment.. All patients were followed up for more than a year. And 31 patients (56.4%) out of 55 achieved complete recovery, 19 (34.5%) attained partial recovery and 5 (9.1%) had no recovery from ONP. Whereas, 20 patients (71.4%) in the embolization + mecobalamin treatment group achieved complete recovery and 11 (40.7%) in the embolization treatment group achieved partial recovery, and the comparative difference was statistically significant (p < 0.05).. Endovascular is highly efficacious treatment for ONP-inducing PcomA and can promote the recovery of oculomotor nerve palsy after embolism.

Topics: Adult; Aged; Embolization, Therapeutic; Endovascular Procedures; Female; Hospitalization; Humans; Intracranial Aneurysm; Male; Middle Aged; Oculomotor Nerve Diseases; Postoperative Complications; Recovery of Function; Treatment Outcome; Vitamin B 12

We evaluated the possible relationships between serum total homocysteine and folate and Vitamin B. We enrolled consecutive patients with intracranial aneurysm from the Han population who were admitted to the hospital, as well as control subjects who received medical examination on an outpatient basis. The serum total homocysteine, folate, and Vitamin B. A total of 140 patients with intracranial aneurysm and 140 control subjects were enrolled from July 2014 to December 2015. The mean serum total homocysteine level in the patient group (19.98 ± 10.84 µmol/L) was significantly higher than that in the control group (15.13 ± 5.55 µmol/L, P < .001). The serum total homocysteine level was negatively correlated with folate and Vitamin B. The present study provides evidence regarding the association between serum total homocysteine and folate and Vitamin B

Topics: Adult; Aged; Asian People; Biomarkers; Case-Control Studies; Chi-Square Distribution; China; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Intracranial Aneurysm; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Prospective Studies; Protective Factors; Risk Factors; Up-Regulation; Vitamin B 12