vitamin-b-12 and Intestinal-Neoplasms

Topics: Anti-Bacterial Agents; Child; Fats; Folic Acid; Humans; Intestinal Absorption; Intestinal Neoplasms; Intestine, Small; Intestines; Jejunum; Lymphoma; Remission, Spontaneous; Sprue, Tropical; Vitamin B 12; Water

Topics: Age Factors; Animals; Child; Child, Preschool; Diarrhea; Disease Outbreaks; Feces; Female; Folic Acid; Humans; Intestinal Absorption; Intestinal Mucosa; Intestinal Neoplasms; Lipid Metabolism; Lymphoma; Male; Sprue, Tropical; Tritium; Vitamin B 12

Patients with small intestinal neuroendocrine tumours (SI-NET) often have diarrhoea from hormonal overproduction, surgery and medical treatment, leading to malabsorption of bile salts, fats, vitamin B12 and fat-souble vitamins. This could lead to malnutrition.. We assessed nutritional status in 50 consecutive out patients with disseminated SI-NET, 25 patients in each cohort. The first cohort was descriptive and the second cohort supplemented with vitamin D, B12 and calcium. Vitamin D deficiency was defined as <50 nmol/l. All patients were assessed by clinical chemistry and dual-energy X-ray absorptiometry (DXA) and interviewed about weight changes, appetite, gastrointestinal disorders, sunhabits and the use of supplements.. In the first cohort, 29% of the patients were severely and 17% moderately vitamin D deficient. In patients without prior substitution, 32% had subnormal vitamin B12 levels. Seventy-six percent had low bone density. In the second cohort with vitamin and mineral supplementation, none had severe vitamin D deficiency, but 28% had moderate deficiency. No patient had subnormal vitamin B12 levels. Sixty percent had low bone density. The serum levels of vitamin D and B12 were higher and parathyroid hormone (PTH) lower in the second cohort compared with the first cohort (P⩽0,022). Vitamin D and PTH were negatively correlated, r=-30, P=⩽0.036.. Low serum levels of vitamin D and vitamin B12, and low bone density are common in patients with disseminated SI-NET. Supplementation of vitamin D, B12 and calcium resulted in higher serum levels of vitamins, lower PTH levels and diminished severe vitamin D deficiency and is thus recommended as standard care.

Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Bone Density; Carcinoid Tumor; Diarrhea; Dietary Supplements; Female; Humans; Intestinal Absorption; Intestinal Neoplasms; Intestine, Small; Male; Middle Aged; Nutritional Status; Parathyroid Hormone; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin D; Vitamin D Deficiency; Vitamins

Increased delivery of taurine-conjugated bile acids to the distal bowel can lead to dysbiosis resulting in colitis in mouse models of inflammatory bowel disease. A similar situation also could occur in cats with intestinal disease and might therefore result in decreased whole-body taurine concentration.. To determine whether whole-blood taurine concentrations are decreased at the time of diagnosis in cats with intestinal disease and to correlate concentrations with clinical and laboratory variables.. Twenty-one cats with chronic inflammatory enteropathy and 7 cats with intestinal neoplasia from the University of Bristol.. Cats that had undergone a thorough investigation consisting of a CBC, serum biochemistry, serum cobalamin and folate concentrations, transabdominal ultrasound examination and histopathology of intestinal biopsy specimens, as well as additional testing if indicated, were included. Whole-blood from these cats collected at the time of histologic diagnosis and stored in ethylenediaminetetraacetic acid was retrospectively analyzed for taurine with an automated high-performance liquid chromatography amino acid analyzer.. Although whole-blood taurine concentrations remained within the reference range, those cats with predominantly large intestinal clinical signs had significantly lower concentrations than did cats with small intestinal and mixed bowel clinical signs (P = 0.033) and this difference also was significant when assessed only in cats with chronic inflammatory enteropathy (P = 0.019).. Additional studies are needed to determine whether large intestinal signs in cats with chronic inflammatory enteropathy are caused by alterations in the microbiota arising as a consequence of increased delivery of taurine-conjugated bile acids.

Topics: Animals; Cat Diseases; Cats; Chromatography, High Pressure Liquid; Colitis; Female; Folic Acid; Intestinal Diseases; Intestinal Neoplasms; Male; Serum Albumin; Taurine; Vitamin B 12

The role of folate one-carbon metabolism in colorectal cancer development is controversial, with nutritional intervention studies producing conflicting results. It has been reported that Apc

Topics: Adenoma; Animals; Choline; Diet; Folic Acid; Intestinal Neoplasms; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Random Allocation; Vitamin B 12

Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Female; Folic Acid Antagonists; Hybridization, Genetic; Intestinal Neoplasms; Leukemia, Experimental; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Neoplasms, Experimental; Quinolinium Compounds; Uterine Cervical Neoplasms; Vitamin B 12

A review has been carried out of patients diagnosed as having coeliac disease some years previously and subsequently lost to follow-up. Most were unaware of the need for continuing treatment and had returned to a normal diet. The resulting morbidity was slight, although one patient had died of a small-bowel lymphoma. If untreated coeliac disease is indeed a pre-malignant condition, then it is suggested that there must be a large population at risk, with no motivation to return to treatment other than the risk of malignancy itself.

Topics: Adolescent; Adult; Anemia; Blood Proteins; Body Constitution; Celiac Disease; Child; Female; Folic Acid; Follow-Up Studies; Glutens; Hemoglobins; Humans; Intestinal Neoplasms; Iron; Jejunum; Lymphoma; Magnesium; Male; Precancerous Conditions; Vitamin B 12

Topics: Calcium; Celiac Disease; Diet Therapy; Dietary Fats; Humans; Infant, Newborn; Intestinal Neoplasms; Lymphangioma; Magnesium; Male; Parenteral Nutrition; Postoperative Care; Triglycerides; Vitamin B 12

This series presents further evidence for an association between reticulosis of the intestine and steatorrhoea. Although some patients have a definite past history of gluten enteropathy, it seems likely that in certain patients the reticulosis itself is the primary cause of the steatorrhoea.

Topics: Ascorbic Acid; Blood Transfusion; Body Weight; Bone Marrow Examination; Celiac Disease; Diet; Diet Therapy; Fats; Feces; Folic Acid; Humans; Intestinal Neoplasms; Intestinal Perforation; Intestine, Small; Iron; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Nandrolone; Neomycin; Neoplasms; Pathology; Prednisone; Sarcoma; Steatorrhea; Surgical Procedures, Operative; Vitamin A; Vitamin B 12; Vitamin B Complex; Vitamins; Water-Electrolyte Balance