vitamin-b-12 and Immunologic-Deficiency-Syndromes

Topics: Chromosomes, Human, Pair 22; Diagnosis, Differential; Genes, Recessive; Humans; Immunologic Deficiency Syndromes; Mutation; Prognosis; Transcobalamins; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Pernicious; Antigens; Autoantibodies; Biopsy; Chronic Disease; Cytoplasm; Digestive System; Female; Fluorescent Antibody Technique; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Immunologic Deficiency Syndromes; Intrinsic Factor; Lipoproteins; Microsomes; Schilling Test; Stomach; Vitamin B 12

A unique case of pernicious anemia is described. Initially, the percentage of OKT8-positive blood cells was markedly decreased, resulting in an increase in the OKT4/OKT8 ratio. The level of OKT8-positive blood cells was, however, returned to normal after vitamin B12 therapy. The finding may propose a possible role of the imbalance of blood lymphocyte subpopulations on the pathogenesis of pernicious anemia and also a responsibility of vitamin B12 for such a selective reduction in the OKT8-positive blood cells.

Topics: Aged; Anemia, Pernicious; Humans; Immunologic Deficiency Syndromes; Male; T-Lymphocytes, Regulatory; Vitamin B 12

Topics: Anemia, Pernicious; Antibody-Dependent Cell Cytotoxicity; Female; Humans; Immunologic Deficiency Syndromes; Killer Cells, Natural; Middle Aged; Vitamin B 12

Topics: Anemia, Pernicious; Autoimmune Diseases; Biological Transport; Blood Proteins; Carrier Proteins; Granulocytes; Humans; Immunologic Deficiency Syndromes; Infant; Male; Polymorphism, Genetic; Transcobalamins; Vitamin B 12

Gastrointestinal (GI) disease is frequently encountered in patients with defective defense mechanisms. The incidence of GI disease and the structure and function of the GI tract have been studied systematically in 41 patients with immunodeficiency syndromes (IDS) and in 9 patients with chronic granulomatous diesase (CGD). Giardia lamblia was a major cause of GI disease in patients with IDS. Eradication of the parasite resulted in disappearance of symptoms and malabsorption, and normalization of the villus architecture. Six of 9 patients with CGD had either GI symptoms or malabsorption or both. Typical histologic changes were found in the small intestinal and rectal mucosa of all patients biopsied.

Topics: Carotenoids; Crohn Disease; Digestive System; Disaccharidases; Feces; Female; Folic Acid; Gastrointestinal Diseases; Giardia; Giardiasis; Granulomatous Disease, Chronic; Histiocytes; Humans; Immunologic Deficiency Syndromes; Intestine, Small; Lactose Intolerance; Malabsorption Syndromes; Male; Metronidazole; Protein-Losing Enteropathies; Rectum; Vitamin B 12

Idiopathic late-onset immunoglobulin deficiency in a young man was associated with achlorhydria and a severe intestinal malabsorption syndrome that did not respond to conventional therapy. Combined therapy with high doses of prednisone and tetracycline hydrochloride resulted in weight gain, cessation of diarrhea, improved absorption of water, fat, and vitamin B12, and production of gastric acid after stimulation with histamine. Serum immunoglobulin levels, however, did not increase.

Topics: Achlorhydria; Adult; Age Factors; Body Weight; Celiac Disease; Cholecystokinin; Diarrhea; Drug Therapy, Combination; Humans; Immunoglobulin M; Immunologic Deficiency Syndromes; Malabsorption Syndromes; Male; Prednisone; Tetracycline; Vitamin B 12

Topics: Adenosine; Agammaglobulinemia; Aminohydrolases; Anemia, Pernicious; Antibody Formation; B-Lymphocytes; Binding Sites, Antibody; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Membrane; Female; Fetus; Fluorescent Antibody Technique; gamma-Globulins; Gastrointestinal Diseases; Hematopoietic Stem Cells; Humans; Immunization, Passive; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunologic Deficiency Syndromes; Male; Vitamin B 12; Vitamin B 12 Deficiency; World Health Organization

Topics: Adult; Anemia, Macrocytic; Biological Transport; Carrier Proteins; Diarrhea; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunodiffusion; Immunoelectrophoresis; Immunologic Deficiency Syndromes; Infant, Newborn; Injections, Intramuscular; Malabsorption Syndromes; Metabolism, Inborn Errors; Pregnancy; Protein Binding; Radioisotopes; Vitamin B 12

Topics: Achlorhydria; Adolescent; Adult; Age Factors; Anemia, Pernicious; Autoantibodies; Gastric Acidity Determination; Humans; Immunoglobulin A; Immunologic Deficiency Syndromes; Intrinsic Factor; Male; Middle Aged; Oral Manifestations; Pedigree; Schilling Test; Vitamin B 12

Topics: Agranulocytosis; Antibodies, Anti-Idiotypic; Blood Chemical Analysis; Erythrocytes; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunologic Deficiency Syndromes; Infant; Karyotyping; Leukocyte Count; Leukocytes; Male; Monocytes; Muramidase; Neutrophils; Phagocytosis; Protein Binding; Rheumatoid Factor; Saliva; Vitamin B 12

Topics: Adolescent; Anemia, Macrocytic; Humans; Immunologic Deficiency Syndromes; Intrinsic Factor; Malabsorption Syndromes; Male; Proteinuria; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Administration, Oral; Complement C5; Dermatitis, Exfoliative; Hereditary Complement Deficiency Diseases; Immunologic Deficiency Syndromes; Vitamin B 12

Topics: Anemia; Complement C5; Dermatitis, Exfoliative; Hereditary Complement Deficiency Diseases; Humans; Immunologic Deficiency Syndromes; Vitamin B 12; Vitamin B Complex

Topics: Anemia; Complement C5; Dermatitis, Exfoliative; Hereditary Complement Deficiency Diseases; Humans; Immunologic Deficiency Syndromes; Vitamin B 12; Vitamin B Complex

Topics: Complement C5; Corrinoids; Dermatitis, Exfoliative; Hereditary Complement Deficiency Diseases; Humans; Immunologic Deficiency Syndromes; Vitamin B 12; Vitamin B Complex