vitamin-b-12 and Hypersensitivity

Topics: Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Celiac Disease; Colitis, Ulcerative; Crohn Disease; Fluorescent Antibody Technique; Gastritis; Gastrointestinal Diseases; Glutens; Humans; Hypersensitivity; Immunoglobulin G; Intrinsic Factor; Vitamin B 12

Although rare, some patients may have a vitamin B12 allergy. Crohn's disease commonly leads to significant vitamin B12 deficiency, especially in those patients that have undergone ileal resection. In these difficult cases, vitamin B12 desensitization may be required.. Here, we report a successful case of a serial outpatient subcutaneous vitamin B12 desensitization protocol in a 35-year-old female with a past medical history of Crohn's disease status post ileal resection, subsequent vitamin B12 deficiency, and allergy to subcutaneous vitamin B12.. This is the first subcutaneous vitamin B12 desensitization protocol reported to have been safely performed in the outpatient setting.

Topics: Adult; Crohn Disease; Female; Humans; Hypersensitivity; Outpatients; Vitamin B 12; Vitamin B 12 Deficiency

MetforminHydrochloride is an antidiabetic used for many years, currently; it considered the first choice in treatment of type 2 diabetes (T2D). It decreases insulin resistance, does not induce hypoglycaemia, increases glucose utilization in the liver and skeletal muscle, and decreases hepatic glucose production. Its adverse effects (AE) are gastrointestinal, decrease in vitamin B12 absorption, abnormalities of hemogram and rarely skin reactions. The objective of this study was to report the type and frequency of AEs of Metformin Hydrochloride used in the therapeutic management of T2D patients admitted to the medical center and the diabetes home of Sidi Bel-Abbès in Algeria.. A cross-sectional descriptive study was carried out over a period of four months, from January 1st, 2017 to April 30th, 2017, involving 130 patients treated with Metformin Hydrochloride consulting at Mimoun City Diabetes Home and Gambetta Diabetes Center in the town of Sidi Bel-Abbès. The primary outcome measure was the determination of the type and frequency of AEs related to normal dosages or overdose use of Metformin Hydrochloride in T2D. Data were collected from patient records, using a questionnaire, and analyzed using Statistical Package for the Social Sciences, version 20 software.. 130 patients were included, including 82 women, with a mean age of 51.08±8.85 years (30-66). One hundred and ninety-eight (198) AEs were reported, an average of 1.52 AEs per patient. Among them, 95 (47.98%) AEs are digestive disorders (30.77% of patients suffered from diarrhea, 10.77% had nausea and vomiting, 8.46% suffered from abdominal pain and bloating, 3.85% lost their taste, 7.69% complained of epigastric cramps and 11.54% of anorexia), 29 (14.65%) AEs are hypoglycaemia, 73 (36.87%) AEs are other symptoms and 1 (0.50%) EI is vitamin B12 deficiency and no cases of lactic acidosis or allergic reaction were reported. Five (3.85%) patients had a total and lasting intolerance to Metformin Hydrochloride leading to its discontinuation following persistent diarrhoea.. AEs of Metformin Hydrochloride used in the management of T2D patients consulting at the medical center and the Diabetes home of Sidi Bel-Abbès are frequent. Digestive disorders were the most frequent, diarrhea was very frequent and led to discontinuation of treatment in 3.85% of T2D patients, followed by nausea and vomiting, then abdominal pain, bloating and epigastric cramps, and rarely taste metallic. Hypoglycaemia was frequent following its association with insulin, the onset of headaches and fatigue were frequent, but no case of lactic acidosis or allergic reaction was reported. Due to a lack of means, the dosage of homocysteine and methylmalonic acid had not been carried out to confirm the vitamin B12 deficiency in the patient whose level was less than 200ng/mL. A precise assessment of the imputability of reported AEs is necessary.

Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hypersensitivity; Hypoglycemia; Hypoglycemic Agents; Metformin; Middle Aged; Muscle Cramp; Nuns; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Child; Child, Preschool; Folic Acid; Homocysteine; Humans; Hypersensitivity; Pediatric Obesity; Respiratory Tract Infections; Vitamin B 12

Deficiency of folate has been associated with several disorders characterized by enhanced activation of the cellular immune system (non-allergic th1 type immune response). Whether folate status is also associated with atopic disease (allergic th2 type immune response) is unknown. We aimed at examining the association between atopy and markers of impaired folate metabolism, i.e. MTHFR(C677T) genotype, plasma total homocysteine, and dietary intakes of methionine, folates, and vitamins B12, B6, and B2.. Cross-sectional population-based study of 1,671 male and female residents of Copenhagen County, Denmark, aged 30-60 years participating in a health examination during 1999-2001. Atopy was defined as positive levels of specific IgE against a panel of inhalant allergens. MTHFR(C677T) genotype was determined by PCR followed by restriction fragment length polymorphism analyses. Total homocysteine was measured by fluorescent polarization immunoassay. Dietary vitamin intakes were estimated from a semi-quantitative food frequency questionnaire.. The prevalence of atopy was associated with MTHFR(C677T) genotype. TT individuals had a significantly higher risk of atopy compared with CC/CT individuals [odds ratio 1.76, 95% confidence interval (95% CI) 1.19-2.60]. Additionally, gene-diet interaction effects were identified. Dietary markers were negatively associated with risk of atopy in persons with the TT genotype. Total homocysteine was not related to atopy (odds ratio per 5 mumol/l = 1.12, 95% CI 0.98-1.29).. The results suggest that an impaired folate metabolism may be causally related to the development of atopy.

Topics: Adult; Cross-Sectional Studies; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Hypersensitivity; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Riboflavin; Risk Assessment; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6

Cyanocobalamin, deoxyadenosylcobalamin and methylcobalamin were separately administered to mice sensitized with the ovalbumin antigen to investigate the allergic response. The serum IgE and pulmonary histamine concentrations were significantly lower in all cobalamin (Cbl)-administered groups. The production of interleukin (IL)-2 and IL-4 in splenocytes was also lower in all Cbl-administered groups. These results show that Cbls were effective in mitigating allergic reactions and IL-2 production. CD3+ CD28+ (CD28 is an accessory molecule related to IL-2 production) and CD4+ CD28+ in splenocytes were higher in all the Cbl-administered groups. However, CD3+ CD28-, CD4+ CD28- and CD5+ CD25- (CD25: IL-2 R alpha/p55) were lower in the Cbl-administered groups. In addition, Cbl specifically inhibited the cellular phosphorylation of tyrosine induced by ovalbumin sensitization. These results indicate that the signal in a cell by CD 28 was restrained by Cbl. We infer that Cbl administration significantly reduced the IL-2 concentration, and secondarily the IL-4, IgE and histamine concentrations.

Topics: Animals; Antigens, CD; Complement C3; Histamine; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Interleukin-2; Liver; Lung; Male; Mice; Mice, Inbred BALB C; Phosphotyrosine; Spleen; Vitamin B 12

Topics: Animals; Blood Cell Count; Copper; Cortisone; Gastrointestinal Hemorrhage; Histamine H1 Antagonists; Hypersensitivity; Intestine, Small; Kidney; Liver; Promethazine; Swine; Swine Diseases; Vitamin B 12

Topics: Achlorhydria; Adult; Agammaglobulinemia; Anemia, Pernicious; Antibodies; Arthritis, Rheumatoid; Atrophy; Autoimmune Diseases; Colitis, Ulcerative; Diarrhea; Female; Fluorescent Antibody Technique; gamma-Globulins; Gastric Mucosa; Gastritis; Giardiasis; Humans; Hypersensitivity; Hypersensitivity, Delayed; Infections; Intrinsic Factor; Male; Middle Aged; Vitamin B 12

Topics: Adolescent; Adult; Aged; Antigen-Antibody Reactions; Asthma; Child; Child, Preschool; Dermatitis, Atopic; Humans; Hydroxocobalamin; Hypersensitivity; Infant; Infant, Newborn; Middle Aged; Vitamin B 12

Topics: Humans; Hydroxocobalamin; Hypersensitivity; Rabies Vaccines; Vitamin B 12

Topics: Alcohols; Benzyl Alcohols; Corrinoids; Humans; Hypersensitivity; Vitamin B 12; Vitamin B Complex

Topics: Corrinoids; Humans; Hypersensitivity; Immune System Diseases; Skin Diseases; Vitamin B 12

Topics: Desensitization, Immunologic; Growth; Humans; Hypersensitivity; Intercellular Signaling Peptides and Proteins; Vitamin B 12

Topics: Corrinoids; Folic Acid; Humans; Hypersensitivity; Skin Diseases; Vitamin B 12; Vitamin B Complex

Topics: Corrinoids; Humans; Hypersensitivity; Immune System Diseases; Skin Diseases; Vitamin B 12

Topics: Anemia; Anemia, Pernicious; Antacids; Anti-Bacterial Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure; Cortisone; Dibenzylchlorethamine; Dicumarol; Epilepsy; Ergot Alkaloids; Heart Failure; Heparin; Histamine Antagonists; Humans; Hyaluronoglucosaminidase; Hydantoins; Hypersensitivity; Hypertension; Hyperthyroidism; Imidazoles; Iodine; Iodine Isotopes; Kidney; Meperidine; Mephenesin; Methadone; Motion Sickness; Norepinephrine; Organomercury Compounds; Peptic Ulcer; Tetraethylammonium; Therapeutics; Thiouracil; Thrombosis; Veratrum; Vitamin B 12

Topics: Anaphylaxis; Anemia; Anemia, Pernicious; Corrinoids; Humans; Hypersensitivity; Liver; Vitamin B 12; Vitamins

Topics: Anaphylaxis; Anemia; Anemia, Pernicious; Corrinoids; Humans; Hypersensitivity; Vitamin B 12

Topics: Anaphylaxis; Corrinoids; Humans; Hypersensitivity; Immune System Diseases; Vitamin B 12; Vitamin B Complex

Topics: Hematinics; Humans; Hypersensitivity; Liver; Liver Extracts; Vitamin B 12; Vitamins