vitamin-b-12 and Hyperemesis-Gravidarum

Topics: Animals; Blood Glucose; Body Composition; Calcium, Dietary; Diet; Dietary Fats; Female; Fetal Development; Folic Acid; Gestational Age; Glycemic Index; Health Promotion; Humans; Hyperemesis Gravidarum; Infant, Newborn; Infant, Small for Gestational Age; Maternal Nutritional Physiological Phenomena; Postprandial Period; Pregnancy; Randomized Controlled Trials as Topic; Taurine; Vitamin B 12; Vitamin D

Topics: Acupressure; Acupuncture Therapy; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Morning Sickness; Phytotherapy; Pregnancy; Vitamin B 12; Zingiber officinale

Topics: Acupressure; Acupuncture Therapy; Adrenal Cortex Hormones; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Phenothiazines; Pregnancy; Pyridoxine; Vitamin B 12

Topics: Acupressure; Acupuncture Therapy; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Morning Sickness; Pregnancy; Vitamin B 12

Topics: Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Pregnancy; Randomized Controlled Trials as Topic; Treatment Outcome; Vitamin B 12; Zingiber officinale

Several reports have suggested the use of acupuncture as a useful treatment for hyperemesis gravidarum (HG), in particular the effects on nausea intensity was underlined. The aim of this study was to compare the efficacy of acupuncture sessions plus acupressure with a metoclopramide/vitamin B12 treatment.. In this study we randomized 88 pregnant patients suffering from HG to receive either acupuncture sessions plus acupressure (acupuncture group) or metoclopramide infusion (metoclopramide group) supplemented by vitamin B12 complex. Somatic symptoms and the ability to achieve the daily routine activity (functioning) were evaluated. Acupuncture sessions were performed at the hospital twice a week for 2 weeks according to the traditional Chinese medicine criteria. Acupression was applied for 6-8 h/day. In the metoclopramide group, patients received at hospital metoclopramide infusion (20 mg/500 mL saline for 60 min) twice a week for 2 weeks. An oral supplementation with vitamin B12 complex (30 mg/day) was also prescribed.. Both treatments reduced vomiting episodes and then nausea intensity with a consequent improvement in the rate of food intake. The effect of acupuncture seems to be progressive, increasing at the end of treatment whereas pharmacological approach has a prompt effect in responders remaining stable thereafter. Moreover, acupuncture was significantly more effective than drugs in improving functioning.. In our study for the first time acupuncture, applied accordingly to Chinese formula, was compared to drugs demonstrating the same effect of both treatments on HG symptoms. Interestingly, functioning was significantly improved just by acupuncture. Even if the effect of acupuncture on HG discomfort remains to be confirmed, the reports on the effect of acupuncture on psychosocial variables could represent a further advantage of acupuncture application and provide an incentive to widen the base of the research.

Topics: Acupressure; Administration, Oral; Adult; Antiemetics; Chi-Square Distribution; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramide; Middle Aged; Pregnancy; Quality of Life; Time Factors; Treatment Outcome; Vitamin B 12

We report the case of a pregnant woman who suffered from hypotension after first exposure to intravenous administration of a combination drug containing vitamins B1, B6 and B12 (Vitamedin; Daiichi-Sankyo, Tokyo, Japan). A 27-year-old Japanese woman received an intravenous infusion of fluid containing a vitamin B complex due to hyperemesis gravidarum. Thirty minutes after the start of infusion she was found to be in hypotension. The patient had stupor, general sweating, blood pressure of 82/50 mmHg, and low percutaneous oxygen saturation (SpO(2)) of 88%. We immediately stopped the infusion, lifted her legs and administered oxygen. Three minutes after these treatments, she quickly recovered to a good general condition. A skin prick test for vitamin B12 was positive, but tests for B1, B6, mannitol and saline were negative, indicating this adverse reaction was one of drug hypersensitivity due to the vitamin B12 in Vitamedin. Patients should be observed carefully immediately after the administration of Vitamedin.

Topics: Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Skin Tests; Thiamine; Vitamin B 12; Vitamin B 6; Vitamin B Complex

Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Pyridoxine; Thiamine; Vitamin B 12

Topics: Female; Gastritis; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Vitamin B 12; Vitamin B Complex; Vomiting