vitamin-b-12 and Herpes-Zoster

Topics: Herpes Zoster; Humans; Injections, Intramuscular; Neuralgia; Pain Measurement; Pilot Projects; Prospective Studies; Treatment Outcome; Vitamin B 12

Postherpetic neuralgia (PHN) is a commonest and difficult-to-manage complication of Herpes zoster. This comparative study included 140 cases of PHN admitted in the department of dermatology in Renmin Hospital of Wuhan University, Wuhan, China, from March 2014 to February 2015, divided into a control and a study group. In addition to the combination of antiviral, analgesic, and neurotrophic agents given to the control group, additional ganglioside GM1 was given to patients in the study group. Pain assessment was performed at the time of admission, and then on the third, seventh and tenth day of treatment, on both groups, using a 10 cm visual analogue scale (VAS). There was a significant statistical difference between the pain VAS score of the two groups, on the seventh day (3.73 ±1.66 vs. 3.03 ±1.86, p=0.024) and on the tenth day (3.25 ±1.78 vs. 2.20 ±1.59, p=0.006) of treatment. The number of patients who have good /and complete response (37.5%) were largely higher in the study group than those in the control group (15%, p < 0.05). This finding demonstrates that the administration of ganglioside GM1 may potentially serve as a neoadjuvant therapy to reduce the severity and duration of pain in PHN patients.

Topics: Administration, Intravenous; Adult; Analgesics; Antiviral Agents; China; Female; G(M1) Ganglioside; Herpes Zoster; Humans; Injections, Intramuscular; Male; Middle Aged; Neuralgia, Postherpetic; Pain Measurement; Thiamine; Treatment Outcome; Vitamin B 12; Vitamin B Complex

The present study was designed to explore the efficacy of locally injected thiamine or cobalamin in relieving itch or pain and improving the daily living activities among patients with herpetic itching.. Eighty eligible patients with herpetic itching with a worst itching score of ≥ 4 were randomized to receive locally injected thiamine (B1 group), cobalamin (B12 group), lidocaine (LD group), or combination of thiamine and cobalamin (COB group) for 4 weeks. The treatment efficacy was assessed based on the patients' pruritus and pain severity, global impression of change, and activities of daily living and quality of life.. After 7 days, thiamine yielded a significant itch relief, cobalamin yielded a significant pain relief, and their combination significantly relieved both pain and itch; which all continued till the endpoint (all Ps<0.001). However, lidocaine did not provide significant itch or pain relief than the other groups. Sixteen patients in the thiamine group achieved ≥ 30% itch reduction; 18 patients in the cobalamin group obtained ≥ 30% pain reduction; and 18 patients achieved ≥ 30% itch reduction and 19 patients obtained ≥ 30% pain reduction in the combination group. The activities of daily living and quality of life data at the endpoint were consistent with a significant benefit in the thiamine (P<0.05), cobalamin, and combination groups (both Ps<0.001).. Locally injected thiamine had a significant antipruritic effect, cobalamin had an analgesic effect, and their combination had the dual effect with no obvious synergies. This intervention was efficacious, tolerable, and safe for herpetic itching.

Topics: Activities of Daily Living; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Female; Herpes Zoster; Humans; Lidocaine; Male; Middle Aged; Neuralgia; Pain Measurement; Pruritus; Quality of Life; Severity of Illness Index; Thiamine; Time Factors; Treatment Outcome; Vitamin B 12

The efficacy of r-interferon alpha 2a (IFM) versus acyclovir (ACV) and vitamin therapy in the treatment of herpes zoster is reported. A total of 305 patients were randomly divided into 3 groups. One million units of IFN were administered i.n. once a day for 6 days in 223 cases, oral ACV 200 mg five times daily for 7 days in 34 cases, and vitamin B12, B1 and B2 therapy at conventional doses for 7-14 days in 48 cases. The results showed that both IFN and ACV could reduce pain in patients with herpes zoster and cut the total duration of symptoms, in comparison with vitamin therapy (P < 0.01). In the IFN group, 45 patients (20.2%) experienced side effects, including mild fever in 35 cases (15.7%) and a slightly depressed leukocyte count or increased serum ALT level (3 cases each). In the ACV group, one complained of discomfort in the gastroenteric tract, and another patient reported lumbodynia.

Topics: Acyclovir; Adolescent; Adult; Aged; Aged, 80 and over; Female; Herpes Zoster; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Recombinant Proteins; Vitamin B 12

From the hospital information system (HIS) of 20 national grade III-A general hospitals, 2 960 cases of herpes zoster as the research object, analyzes the relations between the general information, syndrome of traditional Chinese medicine (TCM), western medicine combined diseases, the relationship between the solar term and the incidence of herpes zoster, and the combined use of Chinese and western medicine. Among the patients with 46-65 year old has the highest percentage of diseased; admission to general outpatient clinic is the most; the most common medical payment is medicare; combined disease such as hypertension, diabetes and coronary heart disease is more common; early treatment effect of herpes zoster is better than the sequelae; summer and autumn solar term patients is hospitalized more, TCM syndrome is damp heat of liver fire; about drugs, western medicine is the most commonly used vitamin B1 and mecobalamin, traditional Chinese medicine is the most frequently used Danhong injection, combination therapy with promoting blood circulation drugs and neurotrophic drugs. Thus, herpes zoster, more common in elderly patients, with no obvious relationship between solar term, should be early diagnosis and early treatment, often with combination of Chinese traditional and western medicine treatment.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Drugs, Chinese Herbal; Female; Herpes Zoster; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Thiamine; Vitamin B 12; Young Adult

Gastrointestinal complications caused by herpes zoster are extremely rare. Here, we described a case of abdominal distention caused by herpes zoster. The patient was a 59-year-old female who suffered from unexplained paroxysmal and a burning pain on the right part of her waist and abdomen, accompanied by abdominal distention. Intestinal pseudo-obstruction was diagnosed by abdominal radiography. Distention of the right abdominal wall was still apparent after one month. In this report, we found that recovery from abdominal distention caused by herpes zoster is difficult and may require surgical intervention.

Topics: Abdomen; Aza Compounds; Fasting; Female; Fluid Therapy; Fluoroquinolones; Herpes Zoster; Humans; Intestinal Pseudo-Obstruction; Middle Aged; Moxifloxacin; Quinolines; Radiography, Abdominal; Treatment Outcome; Vitamin B 12

Topics: Acyclovir; Analgesics; Antiviral Agents; Drug Therapy, Combination; Female; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia; Vitamin B 12

Topics: Aged; Herpes Zoster; Humans; Injections, Intramuscular; Time Factors; Vitamin B 12

Topics: Adult; Aged; Anti-Bacterial Agents; Antiviral Agents; Drug Therapy, Combination; Female; gamma-Globulins; Herpes Zoster; Humans; Male; Middle Aged; Vitamin B 12

Deterioration of acne vulgaris or eruption of an acneiform exanthema could be established during treatment with vitamin B6 and/or vitamin B12 in 14 patients. Females were by far the more frequently affected. The appearance of skin symptoms, even outside the age groups typically affected by acne vulgaris is characteristic. The clinical appearance of acneiform exanthema occurring during treatment with vitamin B6 or B12 consists of loosely disseminated small papules or papulopustules on the face (especially on the forehead and chin), on the upper parts of the back and chest and spreading to the upper arm. The pathogensis of the change is not yet certain. The acneiform rash generally fades within a short time after vitamin B6 or vitamin B12 treatment has been stopped.

Topics: Acne Vulgaris; Adolescent; Adult; Age Factors; Dermatitis, Seborrheic; Exanthema; Female; Herpes Zoster; Humans; Male; Middle Aged; Pyridoxine; Sex Factors; Vitamin B 12

Topics: Adrenal Cortex Hormones; Age Factors; Ambulatory Care; Herpes Zoster; Humans; Muramidase; Vitamin B 12

Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Anti-Bacterial Agents; Arteriosclerosis; Basilar Artery; Cerebrovascular Disorders; Chronic Disease; Deoxyribonucleases; Diabetic Neuropathies; Diuretics; Facial Nerve; Facial Paralysis; Female; Herpes Zoster; Humans; Hypertension; Ischemia; Male; Middle Aged; Physical Therapy Modalities; Prednisolone; Recurrence; Tonsillitis; Vertebral Artery; Vitamin B 12

Topics: Herpes Zoster; Humans; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Pernicious; Costs and Cost Analysis; Drug Prescriptions; England; Herpes Zoster; Humans; Multiple Sclerosis; Statistics as Topic; Vitamin B 12; Wales

Topics: Anti-Bacterial Agents; Diagnosis, Differential; Facial Paralysis; Female; Herpes Zoster; Humans; Middle Aged; Nicotinic Acids; Otitis Media; Palate; Paralysis; Peripheral Nervous System Diseases; Physical Therapy Modalities; Prednisolone; Theophylline; Thiamine; Vitamin B 12

Topics: Aged; Family Practice; Fatigue; Feeding and Eating Disorders; Female; Herpes Zoster; Humans; Male; Multiple Sclerosis; Pregnancy; Vitamin B 12

Topics: Adolescent; Adult; Aged; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Drug Synergism; Estriol; Female; Furosemide; Herpes Zoster; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged; Prednisone; Succinates; Time Factors; Vitamin B 12

Topics: Administration, Oral; Adult; Aged; Child; Female; Herpes Zoster; Humans; Liver Extracts; Male; Middle Aged; Muramidase; Thiamine; Vitamin B 12

Topics: Aged; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Female; Herpes Zoster; Humans; Male; Neuritis; Osteoarthritis; Periarthritis; Pyridoxine; Quinolines; Spinal Diseases; Vitamin B 12

Topics: Adolescent; Adult; Aged; Child; Depression; Facial Paralysis; Herpes Zoster; Humans; Middle Aged; Pain; Perphenazine; Prednisolone; Vitamin B 12

Topics: Adult; Aged; Aminopyrine; Analgesics; Fractures, Bone; Herpes Zoster; Humans; Joint Diseases; Middle Aged; Neuralgia; Pain; Pyridoxine; Quinolines; Rheumatic Diseases; Spinal Diseases; Vitamin B 12

Topics: Adult; Aged; Analgesics; Astringents; Female; Herpes Zoster; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged; Vitamin B 12

Topics: Acute Disease; Aged; Anti-Bacterial Agents; Diathermy; Electrophoresis; Encephalitis; gamma-Globulins; Ganglia; Herpes Zoster; Humans; Male; Massage; Meningism; Meningitis, Viral; Middle Aged; Neuralgia; Neuritis; Pantothenic Acid; Physical Therapy Modalities; Procaine; Radiography; Vitamin B 12; Vitamin B Complex

Topics: Arsenic; Cortisone; Cytopathogenic Effect, Viral; Dexamethasone; Drug Therapy; Epidemiology; Erythromycin; Fluorescent Antibody Technique; Geriatrics; Herpes Zoster; Herpesvirus 3, Human; Humans; Hyaluronoglucosaminidase; Methicillin; Neuralgia; Neutralization Tests; Oxytetracycline; Poisoning; Prednisolone; Spironolactone; Vitamin B 12

Topics: Corrinoids; Folic Acid; General Practice; Hematinics; Herpes Zoster; Humans; Niacin; Niacinamide; Vitamin B 12

Topics: Facial Paralysis; Herpes Zoster; Herpes Zoster Oticus; Humans; Myoclonic Cerebellar Dyssynergia; Sodium Salicylate; Vitamin B 12

Topics: Corrinoids; Folic Acid; Herpes Zoster; Humans; Niacin; Niacinamide; Pyridoxine; Vitamin B 12; Vitamin B Complex

Topics: Herpes Zoster; Humans; Nervous System Diseases; Neuralgia; Neuritis; Pain; Phantom Limb; Pyridoxine; Thiamine; Vitamin B 12; Vitamin B Complex

Topics: Corrinoids; Herpes Zoster; Herpesvirus 3, Human; Humans; Neuralgia; Thiamine; Vitamin B 12; Vitamins

Topics: Adenine Nucleotides; Herpes Zoster; Humans; Multiple Sclerosis; Nervous System Diseases; Neuralgia; Neuritis; Pyridoxine; Thiamine; Vitamin B 12; Vitamins

Topics: Chickenpox; Corrinoids; Hematinics; Herpes Zoster; Humans; Peptides; Vitamin B 12

Topics: Herpes Zoster; Neurology; Vitamin B 12

Topics: Eye Diseases; Herpes Zoster; Herpes Zoster Ophthalmicus; Vitamin B 12

Topics: Corrinoids; Ganglionic Blockers; Hematinics; Herpes Zoster; Vitamin B 12

Topics: Herpes Zoster; Humans; Vitamin B 12

Topics: Herpes Zoster; Humans; Vitamin B 12

Topics: Herpes Zoster; Humans; Nervous System Diseases; Neurology; Pain; Phantom Limb; Trigeminal Neuralgia; Vitamin B 12

Topics: Corrinoids; Hematinics; Herpes Zoster; Vitamin B 12

Topics: Corrinoids; Hematinics; Herpes Zoster; Neuralgia; Vitamin B 12

Topics: Corrinoids; Hematinics; Herpes Zoster; Vitamin B 12

Topics: Corrinoids; Gamma Rays; Hematinics; Herpes Zoster; Vitamin B 12

Topics: Corrinoids; Hematinics; Herpes Zoster; Vitamin B 12

Topics: Corrinoids; Hematinics; Herpes Zoster; Herpesviridae Infections; Vitamin B 12

Topics: Corrinoids; Hematinics; Herpes Zoster; Herpesvirus 3, Human; Humans; Vitamin B 12