vitamin-b-12 and Hemorrhagic-Disorders

Acute promyelocytic leukemia is a form of acute myeloblastic leukemia characterized by hemorrhagic episodes, severe thrombocytopenia and infiltration of the marrow with "hypergranular" promyelocytes, often with multiple Auer bodies. Ultrastructurally. the promyelocytes show many splinter granules and Auer bodies with characteristic hexagonal arrangement of tubules with a periodicity of 250 A. Serum vitamin B12 and B12-binding proteins, in particular, transcobalamin I, are abnormally high. Karyotypic abnormalities include pseudodiploidy and partial deletion of the long arm of chromosome 17. Coagulation profile during bleeding episodes is usually consistent with disseminated intravascular coagulation. Greatly improved prognosis in recent years as a result of aggressive chemotherapy and anticoagulation emphasizes the need of early recognition of this clinical entity.

Topics: Adult; Bone Marrow; Hemorrhagic Disorders; Humans; Karyotyping; Leukemia, Myeloid, Acute; Vitamin B 12

Topics: Adult; Blood Cell Count; Blood Transfusion; Bone Marrow Cells; Bone Marrow Examination; Diagnosis, Differential; Erythrocytes; Erythrocytes, Abnormal; Erythropoiesis; gamma-Globulins; Hemorrhagic Disorders; Humans; Infections; Karyotyping; Leukemia, Myeloid; Liver; Lymph Nodes; Monocytes; Muramidase; Peroxidases; Prognosis; Spleen; Vitamin B 12

Topics: Adult; Anemia, Hemolytic; Anemia, Macrocytic; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Cell Count; Bone Marrow Cells; Erythrocytes; Erythropoiesis; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hemolysis; Hemorrhagic Disorders; Humans; Iron; Leukocytes; Liver; Reticulocytes; Scurvy; Tissue Extracts; Vitamin B 12; Vitamin B 12 Deficiency

Chronic neutrophilic leukemia is a rare, infrequently recognized, myeloproliferative disorder. It usually manifests as a leukemoid reaction, with mostly mature granulocytes in the peripheral blood, with rare to occasional immature forms, and sometimes with normoblasts. The clinical manifestations also include hepatosplenomegaly, elevated leukocytic alkaline phosphatase, elevated serum vitamin B12 and serum vitamin B12 binder ("R" fraction), and elevated serum uric acid. Distinction from a leukemegaly, the absence of sepsis, usually normal erythrocytic sedimentation, and the absence of fever. Leukemoid reactions may be associated with elevated serum vitamin B12 and uric acid, but the levels are usually lower than those found in chronic neutrophilic leukemia. Many patients have gouty symptoms, especially after treatment with Busulfan, and many have an unexplained hemorrhagic tendency, making major operations a risk. The authors add two cases to the 11 previously described.

Topics: Adult; Aged; Alkaline Phosphatase; Bone Marrow; Chromosomes, Human, 21-22 and Y; Hemorrhagic Disorders; Hepatomegaly; Humans; Leukemia, Myeloid; Leukocytes; Male; Middle Aged; Muramidase; Uric Acid; Vitamin B 12

It is reported on a patient with Addison-Biermer's disease who was admitted to hospital under the diagnosis of a bleeding ventricle ulcer and in whom was detected a thrombocytopenic haemorrhagic diathesis. By means of injections of vitamin B12 a complete haematologic remission was achieved. The absence of a clear increase of reticulocytes as a sequel of the blood transfusions performed before the specific therapy is discussed.

Topics: Adult; Anemia, Pernicious; Blood Transfusion; Diagnosis, Differential; Hemorrhagic Disorders; Humans; Male; Peptic Ulcer; Thrombocytopenia; Vitamin B 12

Topics: Animals; Bone Marrow; Bone Marrow Cells; Enterobacteriaceae; Female; Hematopoiesis; Hemorrhagic Disorders; Intestines; Kidney; Lymph Nodes; Male; Palatine Tonsil; Radiation Effects; Radiation Injuries, Experimental; Sepsis; Spleen; Swine; Testis; Vitamin B 12

Topics: Animals; Blood Cells; Guinea Pigs; Hematopoiesis; Hematopoietic System; Hemorrhagic Disorders; Lymphatic System; Radiation Effects; Radiation Injuries, Experimental; Radiation-Protective Agents; Radiobiology; Rats; Swine; Vitamin B 12

Topics: Cushing Syndrome; Female; Hemorrhage; Hemorrhagic Disorders; Humans; Phenacetin; Postpartum Hemorrhage; Postpartum Period; Vitamin B 12

Topics: Bleeding Time; Hemorrhagic Disorders; Humans; Vitamin B 12

Topics: Blood Platelets; Hemorrhagic Disorders; Humans; Plasma; Vitamin B 12