vitamin-b-12 and Hematuria

To evaluate the haematological changes induced by a long-distance race in well trained runners.. The haematological changes presented by 17 runners (15 men and 2 women) were assessed in a 6-hour race. For this purpose samples were examined before the race, 2 hours later, 4 hours later, at the end of the race, and 4 days after the trial.. Haemoglobin rates, as well as leucocyte, neutrophil, monocyte and platelet counts were increased, probably due to decreased plasma volume. Haemolytic traits were seen as well, namely, increased reticulocyte count and decreased haptoglobin. High transferrin-transport capability and serum B12 levels were also present. Mild haematuria was found without any haemosiderinuria, siderinuria or haemoglobinuria. All these changes recovered in the post-race study.. Changes in the major haematologic values are present during long-distance races, some of them due to haemoconcentration. Leucocytosis, haemolysis and haematuria are noteworthy, and these findings must be borne in mind when evaluating the health of runners.

Topics: Adult; Blood Cell Count; Blood Proteins; Female; Ferritins; Folic Acid; Hematuria; Hemoglobins; Hemolysis; Humans; Iron; Leukocytosis; Male; Middle Aged; Running; Transferrin; Vitamin B 12

Acute promyelocytic leukaemia (A.P.L.) is a rare but important type of acute myeloid leukaemia characterized by major bleeding in association with thrombocytopenia, a specific peripheral blood and bone marrow picture, low plasma fibrinogen, and the presence in the serum of fibrin degradation products. These last abnormalities are related to the disseminated intravascular consumption of coagulation factors with secondary fibrinolysis. A.P.L. requires early recognition and urgent treatment. With optimal management up to half of the patients may achieve complete remission of two years or more. Undoubtedly patients with A.P.L. do especially well when treated in special centres and some patients with A.P.L. now die before the nature of their disease is recognized. Increased familiarity with the problem, which has been known for nearly 20 years, should yield great dividends for those few patients who have this disease.

Topics: Acid Phosphatase; Binding Sites; Bone Marrow Cells; Erythrocytes; Factor V; Factor VIII; Fibrinogen; Hematuria; Hemorrhage; Heparin; Humans; Leukemia, Myeloid; Leukocyte Count; Peroxidases; Platelet Transfusion; Prognosis; Prothrombin; Purpura; Remission, Spontaneous; Thrombocytopenia; Vitamin B 12

Topics: Anemia; Biopsy, Needle; Castration; Cholesterol; Diethylstilbestrol; Estrogens; Folic Acid; Hematuria; Humans; Iron; Lipoproteins; Lymph Nodes; Male; Neoplasm Metastasis; Prostatectomy; Prostatic Neoplasms; Prostatitis; Testosterone; Triglycerides; Uremia; Urination Disorders; Vitamin B 12