vitamin-b-12 and Heart-Diseases

Topics: Dietary Supplements; Folic Acid; Heart Diseases; Homocysteine; Humans; Pyridoxine; Risk Factors; Vitamin B 12

Anaemia and iron deficiency are frequent in patients scheduled for cardiac surgery. This study assessed whether immediate preoperative treatment could result in reduced perioperative red blood cell (RBC) transfusions and improved outcome.. In this single-centre, randomised, double-blind, parallel-group controlled study, patients undergoing elective cardiac surgery with anaemia (n=253; haemoglobin concentration (Hb) <120 g/L in women and Hb <130 g/L in men) or isolated iron deficiency (n=252; ferritin <100 mcg/L, no anaemia) were enrolled. Participants were randomly assigned (1:1) with the use of a computer-generated range minimisation (allocation probability 0·8) to receive either placebo or combination treatment consisting of a slow infusion of 20 mg/kg ferric carboxymaltose, 40 000 U subcutaneous erythropoietin alpha, 1 mg subcutaneous vitamin B12, and 5 mg oral folic acid or placebo on the day before surgery. Primary outcome was the number of RBC transfusions during the first 7 days. This trial is registered with ClinicalTrials.gov, number NCT02031289.. Between Jan 9, 2014, and July 19, 2017, 1006 patients were enrolled; 505 with anaemia or isolated iron deficiency and 501 in the registry. The combination treatment significantly reduced RBC transfusions from a median of one unit in the placebo group (IQR 0-3) to zero units in the treatment group (0-2, during the first 7 days (odds ratio 0·70 [95% CI 0·50-0·98] for each threshold of number of RBC transfusions, p=0·036) and until postoperative day 90 (p=0·018). Despite fewer RBC units transfused, patients in the treatment group had a higher haemoglobin concentration, higher reticulocyte count, and a higher reticulocyte haemoglobin content during the first 7 days (p≤0·001). Combined allogeneic transfusions were less in the treatment group (0 [IQR 0-2]) versus the placebo group (1 [0-3]) during the first 7 days (p=0·038) and until postoperative day 90 (p=0·019). 73 (30%) serious adverse events were reported in the treatment group group versus 79 (33%) in the placebo group.. An ultra-short-term combination treatment with intravenous iron, subcutaneous erythropoietin alpha, vitamin B12, and oral folic acid reduced RBC and total allogeneic blood product transfusions in patients with preoperative anaemia or isolated iron deficiency undergoing elective cardiac surgery.. Vifor Pharma and Swiss Foundation for Anaesthesia Research.

Topics: Administration, Intravenous; Administration, Oral; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Cardiac Surgical Procedures; Double-Blind Method; Drug Therapy, Combination; Erythrocyte Transfusion; Erythropoietin; Female; Ferric Compounds; Folic Acid; Heart Diseases; Humans; Male; Maltose; Middle Aged; Preoperative Care; Prospective Studies; Time Factors; Vitamin B 12

Topics: Citrates; Cobalt Radioisotopes; Depression, Chemical; Heart Diseases; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Malabsorption Syndromes; Male; Potassium; Schilling Test; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Heart Diseases; Humans; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Malabsorption Syndromes; Male; Potassium Chloride; Schilling Test; Telemetry; Vitamin B 12; Vitamin B 12 Deficiency

To explore whether maternal vitamin B12 and folate status during early pregnancy are associated with cardiometabolic risk factors in the offspring at age 5-6.. Prospective multi-ethnic birth cohort, the Amsterdam Born Children and their Development study (ABCD).. 12,373 pregnant women living in Amsterdam were approached between 2003 and 2004 for participation in the study.. Mother-child pairs for whom information on maternal vitamin B12 or folate status in early gestation and health at age 5-6 years was available (n = 1950).. Vitamin B12 and folate concentrations were determined in maternal serum at intake in early pregnancy (median 13 weeks' gestation). Anthropometric measurements, blood pressure and fasting blood samples were collected during a health check of children aged 5-6 years. Multiple linear regression was performed to investigate the association between maternal serum concentrations and children's outcomes, corrected for confounders.. Gestational age at birth, birthweight, body mass index (BMI), glucose levels, triglyceride levels, blood pressure and heart rate of the offspring at age 5-6.. Low maternal folate levels during early pregnancy were associated with slightly higher BMI in the offspring [decrease per 10 units: β 0.07 kg/m(2), 95% confidence interval (CI) 0.01, 0.13]. Low maternal vitamin B12 concentrations were associated with higher heart rates (decrease per 100 units: β 0.49 beats/min, 95% CI 0.11, 0.87).. This study provides further evidence that maternal nutrition in early pregnancy may possibly program cardiometabolic health of the offspring.. Low folate and vitamin B12 levels during pregnancy are associated with higher BMI and heart rate in offspring.

Topics: Adult; Child; Child, Preschool; Ethnicity; Female; Folic Acid; Folic Acid Deficiency; Heart Diseases; Humans; Male; Metabolic Diseases; Pregnancy; Pregnancy Complications; Prospective Studies; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency

Vitamin B12 plays a vital role in neuronal development, particularly in myelinogenesis. Demyelination of the autonomic nervous system occurs early in vitamin B12 deficiency. However, the impact of maternal vitamin B12 deficiency during pregnancy on neuronal function in the offspring is poorly documented. The objective of this study was to assess cardiac autonomic nervous activity in children born to mothers with low vitamin B12 status during pregnancy using heart rate variability (HRV) indices in the frequency domain. Seventy-nine healthy children between 3 and 8 years of age were evaluated from an ongoing birth cohort. The blood sample of the mother had been stored and was analysed for plasma vitamin B12 following enrolment of the child. Subjects were divided, based on the median maternal first trimester vitamin B12 status (114 pmol L(-1)), into lower (n = 40) and higher (n = 39) vitamin B12 status groups. A lead II electrocardiogram was recorded in the supine posture and subjected to HRV analysis. Low-frequency HRV in absolute units was reduced significantly in children of the lower vitamin B12 status group (P = 0.03) and was 53% that of the higher vitamin B12 status group. There was a significant association between low-frequency and total power HRV with cord blood vitamin B12 levels (ρ = 0.31 and 0.30, both P = 0.03). In summary, children born to mothers with a lower vitamin B12 status have a reduced cardiac sympathetic activity. The long-term implication of this needs to be evaluated by follow-up studies.

Topics: Adult; Anthropometry; Child; Child, Preschool; Cohort Studies; Electrocardiography; Female; Fetal Blood; Heart Diseases; Heart Rate; Humans; India; Maternal Nutritional Physiological Phenomena; Nutritional Status; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Sympathetic Nervous System; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult

We prospectively investigated relationships between blood markers of Fe, vitamin B12, folate, vitamin C and vitamin D status and subsequent all-cause mortality in 208 men and 191 women aged 75 years or over living in the community in Aberdeen, Scotland. The participants had been recruited for a cross-sectional study in 1999-2000 when they completed health and lifestyle questionnaires and had blood samples taken for analysis of serum ferritin, serum vitamin B12, erythrocyte folate, plasma vitamin C and serum 25-hydroxycholecalciferol. Mortality was ascertained on national databases up to December 2005, with a median time of follow up of 69.2 (range 1.0-79.9) months. Participants were divided into sex-specific quintiles of baseline levels for each nutrient, and hazard ratios were estimated with Cox proportional hazard models adjusted for age and sex with the significance of linear trends in the associations assessed by logistic regression. There was no significant association between blood markers of Fe, vitamin B12 or folate status at baseline and mortality, but vitamin D status at baseline was inversely related to mortality (P for trend < 0.001). For vitamin C there was no evidence of a linear trend but participants in the lowest quintile of plasma levels had a significantly higher risk of death than those in the highest quintile. Randomized controlled trials of lifestyle changes which improve vitamin status are needed to assess whether these associations could be causal.

Topics: Aged; Aged, 80 and over; Ascorbic Acid; Dietary Supplements; Female; Folic Acid; Heart Diseases; Humans; Iron; Life Style; Male; Mortality; Nutritional Status; Prospective Studies; Risk Assessment; Scotland; Self Concept; Sex Distribution; Socioeconomic Factors; Vitamin B 12; Vitamin D

To investigate the inter-relation between mother and infant homocysteine, folate and vitamin B12 status and the risk of a child with congenital heart disease (CHD).. Case-control study.. Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.. Participants were 149 case-mothers and their children with CHD (n = 151) and 183 control-mothers with their children (n = 175).. Approximately 17 months after the index-pregnancy maternal fasting, children's random venous blood samples were drawn to measure plasma total homocysteine, serum and red blood cell (RBC) folate, and serum vitamin B12 concentrations. Data were compared between cases and controls using the Mann-Whitney U test. The biochemical parameters were dichotomised according to the cutoff value of the 10th percentile of vitamin concentrations and the 90th percentile of homocysteine concentrations based on control data. Risk estimates for the association between CHD and the biochemical parameters were estimated in a logistic regression model.. Medians (minimum-maximum) and odds ratios (OR) (95% confidence intervals [CI]).. The OR (95% CI) of having a child with CHD was 2.9 (1.4-6.0) for maternal hyperhomocysteinaemia (>14.3 micromol/l). This finding is substantiated by a significant concentration-dependent risk (Ptrend = 0.004). Hyperhomocysteinaemic case-mothers showed significantly lower serum folate and vitamin B12 concentrations than normohomocysteinaemic case-mothers. Serum and RBC folate concentrations were significantly higher in case-children than that in control-children.. Maternal hyperhomocysteinaemia is associated with an increased risk of CHD, partially due to low folate and vitamin B12 status. The folate status of children warrants further investigation.

Topics: Adult; Case-Control Studies; Female; Folic Acid; Heart Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Maternal Age; Pregnancy; Pregnancy Complications; Risk Factors; Statistics, Nonparametric; Vitamin B 12

Topics: Aged; Bibliometrics; Cardiology; Clopidogrel; Cohort Studies; Coronary Restenosis; Drug Resistance; Estrogen Receptor alpha; Female; Folic Acid; Genetic Predisposition to Disease; Heart Diseases; Humans; Male; Mass Screening; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recurrence; Risk; Stents; Ticlopidine; Vitamin B 12; Vitamin B 6

Topics: Folic Acid; Heart Diseases; Humans; Hyperhomocysteinemia; Vitamin B 12; Vitamin B 6

Too much homocysteine in the blood is associated with an increased risk of heart and circulatory diseases. Blood tests can detect the problem, and it can often be treated with nutrition and suplements. Here is some background on this potential approach to reducing cardiovascular risk.

Topics: Diet; Folic Acid; Heart Diseases; HIV Infections; Homocysteine; Humans; Vitamin B 12

This study was undertaken to examine the effects of aldose reductase inhibitor (ARI) and vitamin B12 (VB12) on myocardial uptake of iodine-123 metaiodobenzylguanidine (MIBG) in patients with diabetic autonomic disorder. Myocardial scintigraphy using 123I-MIBG was performed on 20 healthy volunteers (controls) and 56 patients with non-insulin-dependent diabetes mellitus (NIDDM), in order to obtain the heart/mediastinum ratio in the initial (HMi) and the delayed images (HMd), and the washout rate (%WR). Thirty-four of the 56 NIDDM patients could be diagnosed as having diabetic autonomic disorder by evaluating their scintigraphic findings in comparison with the controls. Seventeen of these 34 patients received 150 mg/day of doses before meals, and the other 17 received 1.5 mg/day of mecobalamin (VB12 group) in three divided doses after meals, for 3-5 months. According to the presence or absence of clinical symptoms of autonomic or peripheral somatic nerve disorder, the patients were subclassified into four groups. group 1=patients, with autonomic symptoms or somatosensory disorder in the ARI group; group 2=patients without autonomic symptoms or somatosensory disorder in the ARI group; group 3=patients with autonomic symptoms or somatosensory disorder in the VB12 group; and group 4=patients without autonomic symptoms or somatosensory disorder in the VB12 group. After completion of the treatment, myocardial scintigraphy was performed again. Comparing the results obtained before and after the treatment, it was seen that ARI improved only the HMi in group 1 (P=0.046), whereas VB12 significantly improved HMi in the group 3 (P=0.018) and HMi, HMd and %WR in group 4 (P=0.043, P=0.018 and P=0.043, respectively). We conclude that VB12 is more efficacious than ARI in the treatment of diabetic cardiovascular autonomic disorder.

Topics: 3-Iodobenzylguanidine; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Autonomic Nervous System Diseases; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Heart; Heart Diseases; Humans; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Rhodanine; Thiazolidines; Vitamin B 12

The lithium content of human hair shows an approximately linear response to extradietary lithium supplementation at dosage levels of up to 2000 micrograms/d. From the mean hair lithium concentration of 0.063 micrograms/g in 2648 predominantly American adults, and the reference hair lithium concentrations determined in the present study, the mean lithium intakes were calculated to be 730 micrograms/d. Hair lithium concentrations were extremely low in nearly 20% of the American samples, and in samples collected in Munich, Germany and Vienna, Austria. Hair lithium levels are low in certain pathological conditions, e.g., heart disease, in learning-disabled subjects, and in incarcerated violent criminals. The highest levels were observed in samples of a lithium-treated psychiatric patient. A statistically highly significant direct association was observed between the hair lithium and cobalt concentrations, which suggests a role of lithium in the transport and distribution of vitamin B12. Interactions of lithium with other trace elements are also discussed.

Topics: Adult; Cobalt; Hair; Heart Diseases; Humans; Lithium; Manganese; Mental Disorders; Scalp; Trace Elements; Violence; Vitamin B 12

Topics: Alloys; Anemia; Animals; Beer; Cobalt; Enzyme Inhibitors; Food Contamination; Heart Diseases; Heme; Humans; Hyperlipidemias; Iron; Joint Prosthesis; Lipids; Neoplasms; Tissue Distribution; Vitamin B 12

Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Digitalis Glycosides; DNA; Drug Combinations; Heart Diseases; Magnesium; Potassium; Selenium; Swine; Swine Diseases; Vitamin B 12

Topics: Adult; Aged; Anemia; Asthenia; Body Weight; Cachexia; Chronic Disease; Cytidine; Diabetes Complications; Female; Heart Diseases; Humans; Hyperthyroidism; Liver Diseases; Liver Extracts; Male; Middle Aged; Nucleosides; Uridine; Vitamin B 12

Topics: Anabolic Agents; Androstenols; Folic Acid; Heart Diseases; Humans; Nicotinic Acids; Pyridoxine; Vitamin B 12

Topics: Age Factors; Aged; Anabolic Agents; Folic Acid; Heart Diseases; Humans; Nicotinic Acids; Osteomalacia; Osteoporosis; Pyridoxine; Vitamin B 12

Topics: Adenine Nucleotides; Adult; Aged; Coronary Disease; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Myocarditis; Thiamine Pyrophosphate; Vitamin B 12

Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Heart Diseases; Hepatitis A; Humans; Hypersplenism; Liver Cirrhosis; Liver Extracts; Lung Diseases; Middle Aged; Vitamin B 12; Vitamin E; Vitamin K 1

Topics: Anemia; Anemia, Hemolytic; Blood Protein Disorders; Brain Neoplasms; Chlormerodrin; Chromium Isotopes; Clinical Laboratory Techniques; Cobalt Isotopes; Diuretics; Erythrocytes; Heart Diseases; Hypoproteinemia; Iodine Isotopes; Kidney Diseases; Liver Diseases; Lung Diseases; Neoplasms; Obesity; Organomercury Compounds; Polycythemia; Protein Deficiency; Pulmonary Embolism; Radiation Protection; Radioisotopes; Radiometry; Radionuclide Imaging; Schilling Test; Spleen; Thinness; Thyroid Diseases; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Heart Diseases; Hematinics; Humans; Iron; Vitamin B 12

Topics: Adenine Nucleotides; Adenosine Monophosphate; Heart Diseases; Humans; Pulmonary Heart Disease; Thiamine Pyrophosphate; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Cardiotonic Agents; Corrinoids; Heart Diseases; Humans; Liver Extracts; Polyphosphates; Sodium; Uracil Nucleotides; Uridine; Uridine Triphosphate; Vitamin B 12

Topics: Corrinoids; Heart Diseases; Hematinics; Hematologic Diseases; Humans; Neoplasms; Vitamin B 12

Topics: Corrinoids; Heart Diseases; Hematinics; Humans; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex