vitamin-b-12 and Glaucoma

Topics: Adrenalectomy; Amblyopia; Aminosalicylic Acids; Anticoagulants; Cataract; Clofibrate; Diabetic Retinopathy; Diet; Diplopia; Fructose; Glaucoma; Humans; Light Coagulation; Lipotropic Agents; Pituitary Gland; Retina; Rutin; Steroids; Vision Disorders; Vitamin B 12

To compare peripapillary retinal nerve fiber layer (RNFL) thicknesses measured by Cirrus HD optical coherence tomography (OCT) of patients with vitamin B12 deficiency with healthy controls and to evaluate the correlation between the peripapillary RNFL thickness and plasma vitamin B12 levels.. Forty-five patients (19 male and 26 female) with a diagnosis of vitamin B12 deficiency (patient group) and 45 age- and sex- matched healthy subjects (control group) were consecutively enrolled in this study. Average, temporal, nasal, inferior, and superior quadrant peripapillary RNFL thicknesses of each subject were obtained using the Cirrus HD OCT. Disc area (DA) and rim area (RA), central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were also measured.. Mean age of each group was 33.1 ± 6.5 years (range: 21-45 years). Mean plasma vitamin B12 level was 114.8 ± 34.0 pg/mL in the patient group and was 405.1 ± 20.0 pg/mL in the control group (p < 0.001). The patient and control groups were similar regarding axial length, plasma folate levels, DA, RA, CST, CV, CAT, and RNFL thicknesses in superior, nasal, and inferior quadrants. However, average RNFL and RNFL in temporal quadrant were significantly thinner in the patient group than in the control group (p = 0.013 and p < 0.001, respectively). In addition, temporal (r = 0.356, p = 0.001) and average (r = 0.212, p = 0.045) peripapillary RNFL thicknesses were correlated with plasma vitamin B12 levels.. We have shown that, as in other non-glaucomatous optic neuropathies, temporal quadrant RNFL thickness was thinner in patients with vitamin B12 deficiency and it was correlated with plasma vitamin B12 levels. Further studies are warranted to clarify the clinical relevance of these findings and the effects of vitamin B12 replacement therapy.

Topics: Adult; Female; Glaucoma; Humans; Male; Middle Aged; Nerve Fibers; Optic Disk; Optic Nerve Diseases; Retina; Retinal Degeneration; Tomography, Optical Coherence; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult

The aim of this study was to evaluate the levels of plasma homocysteine (Hcy), vitamin B12, and folic acid in patients with pseudoexfoliation glaucoma (PEXG), pseudoexfoliation syndrome (PEXS), PEXS plus normotensive glaucoma (NTG).. In total, 24 patients with PEXG, 35 patients with PEXS, 18 patients with PEXS plus NTG, and 35 control subjects were enrolled into study. Their Hcy levels were measured by high performance liquid chromatography (HPLC); the levels of vitamin B12 and folic acid were measured by a competitive electrochemiluminescence immunoassay.. Higher plasma Hcy levels and lower folic acid and vitamin B12 levels were found in all 3 patients' groups compared with the control group (all P<0.001, expect for folic acid in the PEXG group, P=0.03). Although plasma Hcy levels in the PEXG and PEXS groups were similar, the PEXS plus NTG group had significantly higher Hcy levels compared with these groups (P=0.019 and P=0.032, respectively).. Our study showed that there was an association between hyperhomocysteinemia and PEXS either with or without glaucoma. The patients with PEXS plus NTG had higher plasma Hcy levels than the patients with PEXS or PEXG and the healthy controls. The treatment of hyperhomocysteinemia by taking low-cost vitamin B12 and folic acid preparations may prevent additional vascular problems.

Topics: Aged; Exfoliation Syndrome; Female; Folic Acid; Glaucoma; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12

This study was performed to compare levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with primary open-angle glaucoma (POAG), pseudoexfoliative glaucoma (PEXG), normotensive glaucoma (NTG) and healthy controls.. Twenty-five patients with POAG, 24 with PEXG, and 18 with NTG, along with 19 control healthy subjects were included this prospective study. Levels of serum Hcy were measured using immunoassay, and those of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay.. The mean Hcy concentration in the PEXG group was significantly higher (P < 0.001) as compared to the other groups. There were no significant differences with respect to the mean Hcy concentrations among other groups (P > 0.05). There were no statistical differences in serum vitamin B12 levels among POAG, PEXG, NTG and control subjects (P > 0.05). The mean serum folic acid level was significantly lower in the subjects with PEXG (P < 0.009). However, the mean folic acid concentrations among the other groups did not differ significantly (P > 0.05).. Elevated levels of Hcy in PEXG may explain the role of endothelial dysfunction among patients with PEXG.

Topics: Aged; Analysis of Variance; Case-Control Studies; Exfoliation Syndrome; Female; Folic Acid; Glaucoma; Glaucoma, Open-Angle; Homocysteine; Humans; Male; Middle Aged; Osmolar Concentration; Vitamin B 12

To determine and compare the plasma levels of homocysteine and vitamin B (B6, B12 and folate) in patients with Pseudoexfoliation syndrome (PEXS), pseudoexfoliation glaucoma (PEXG), retinal vein occlusion with pseudoexfoliation (PEX+RVO) and in normal individuals.. The current study was conducted in the Third Eye Clinic, Ankara Numune Training and Research Hospital, Turkey, between August 2004 and February 2005. Twenty cases with PEXS (Group 1), 20 cases with PEXG (Group 2), 16 cases with PEX+RVO (central or branch retinal vein occlusion) (Group 3) and 20 normal individuals (control group) were included in the study. Those who use vitamin supplements or drugs affecting the plasma homocysteine levels were excluded from the study.. Plasma homocysteine levels were 17.6+/-4.4 mmol/l in Group 1, 18.5+/-4.5 mmol/l in Group 2, 22.2+/-6.0 mmol/l in Group 3, and 14.0+/-3.1 mmol/l in the control group. It was highest in Group 3 (p<0.001). The ratio of hyperhomocysteinemia was calculated as 35% (Group 1), 45% (Group 2), 68.7% (Groups 3) and 15% (control). These values were statistically higher in the groups with PEXS than in the control group (p=0.009). We did not find any statistically significant difference between the groups with respect to the levels of vitamin B6 and B12 (p>0.05), but the level of folate was lowest in Group 3 (p<0.001).. Hyperhomocysteinemia is a risk factor for thromboembolic vasculopathy in patients with PEXS and PEXG. Therefore, vitamin B supplementation should be considered in these patients when hyperhomocysteinemia is detected.

Topics: Aged; Exfoliation Syndrome; Eye; Female; Folic Acid; Glaucoma; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Retinal Vein Occlusion; Risk Factors; Turkey; Vitamin B 12; Vitamin B 6

Topics: Adult; Aged; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Visual Acuity; Vitamin B 12

Topics: Adult; Aged; Female; Glaucoma; Humans; Male; Middle Aged; Retina; Visual Fields; Vitamin B 12

Topics: Adolescent; Adult; Aged; Amblyopia; Child; Child, Preschool; Chlorpropamide; Glaucoma; Humans; Hydroxocobalamin; Male; Middle Aged; Nutrition Disorders; Optic Atrophy; Optic Nerve; Scotoma; Smoking; Streptomycin; Tetracycline; Visual Fields; Vitamin B 12

Topics: Adaptation, Ocular; Adult; Aged; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Miotics; ortho-Aminobenzoates; Visual Fields; Vitamin B 12

Topics: Glaucoma; Humans; Vitamin B 12

Topics: Glaucoma; Humans; Visual Perception; Vitamin B 12

Topics: Aqueous Humor; Corrinoids; Drug Therapy; Glaucoma; Humans; Visual Field Tests; Vitamin B 12

Topics: Glaucoma; Humans; Niacin; Nicotinic Acids; Retina; Retinitis Pigmentosa; Vitamin B 12