vitamin-b-12 and Gastroenteritis

Topics: Anti-Bacterial Agents; Bile Acids and Salts; Blind Loop Syndrome; Dietary Fats; Enterobacteriaceae; Folic Acid; Gastroenteritis; Humans; Intestinal Mucosa; Intestine, Small; Jejunum; Sprue, Tropical; Vitamin B 12

Topics: Adenoma, Islet Cell; Carbohydrates; Cardiovascular Diseases; Celiac Disease; Diabetes Mellitus; Fatty Acids; Gastrectomy; Gastroenteritis; Glutens; Hematinics; Humans; Liver Diseases; Radiation Injuries; Vitamin B 12

Phosphorylcholine and homocysteine have an important choleretic action and also potentiate exocrine pancreatic secretion by way of stimulation and a more effective preparation of the substrate against attack by lipolytic enzymes. The protection offered by pancreatic enzymes in the correction of the digestive insufficiency in the endoluminal stage is also known. An analysis was therefore made of the action of an association of phosphorylcholine homocysteine and digestive enzymes in cases of exocrine pancreatic insufficiency and primary or secondary malabsorption. This action was evaluated on the basis of the reduction of elimination of steatorrhoea. For this purpose, faecal lipids were determined with the method proposed by van de Kramer et al. The most significant results were obtained in cases where digestive insufficiency was most marked, where correction of the pancreatic enzyme deficiency and improved biliary function were particularly required.

Topics: Adolescent; Adult; Aged; Amylases; Celiac Disease; Cholagogues and Choleretics; Choline; Clinical Trials as Topic; Crohn Disease; Drug Combinations; Drug Evaluation; Female; Gastroenteritis; Homocysteine; Humans; Male; Middle Aged; Pancreatic Neoplasms; Pancreatitis; Pronase; Silicone Elastomers; Vitamin B 12; Whipple Disease

In a group of nine children with postenteritis enteropathy (i.e., persisting small-intestinal mucosal damage and failure-to-thrive after an acute episode of gastroenteritis), absorption capacities for vitamin B12 and folic acid were studied and compared with hematological status in peripheral blood. The fractional absorptions of vitamin B12 (FAB12) and folic acid (FAFol) were determined by means of a double-isotope technique employing a single-stool-sample test. The children were examined when growth retardation was maximal, and examinations were repeated during the late recovery period. In spite of considerable small-intestinal mucosal damage, only the absorption of vitamin B12 was markedly affected, while that of folic acid was almost intact. When growth retardation was maximal, FAB12 was below the normal age-correlated range in half of the children. FAB12 was also severely reduced in all longitudinally observed children when compared with the results obtained during the late recovery period (p less than 0.005). FAFol was below the normal range in one fourth of the children, but the reduction was modest and insignificant when compared with the results of repeated examinations during the late recovery period. A moderate iron deficiency was detected in half the children. High levels of plasma vitamin B12, folic acid, and erythrocyte folate were detected at both early and later examinations, indicating that these parameters were not affected by the reduced absorption capacities. However, if malabsorption and chronic diarrhea are combined with low dietary intake of vitamin B12, as is the case for many children in the Third World, depletion of vitamin B12 stores may result.

Topics: Absorption; Diarrhea; Erythrocyte Indices; Failure to Thrive; Female; Folic Acid; Gastroenteritis; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Vitamin B 12

Topics: Adolescent; Age Factors; Body Weight; Child; Child, Preschool; Citrates; Copper; Dyspepsia; Feeding and Eating Disorders; Gastroenteritis; Humans; Infant; Infant, Newborn; Iron; Manganese; Nucleotides; Respiratory Tract Infections; Vitamin B 12

Topics: Anti-Bacterial Agents; Carbohydrate Metabolism; Cholera; Diarrhea; Drug Therapy; Folic Acid; Foodborne Diseases; Gastroenteritis; Humans; Intestine, Small; Intestines; Malabsorption Syndromes; Pakistan; Salmonella Infections; Shigella; Staphylococcal Infections; Statistics as Topic; Vitamin B 12; Xylose

Topics: Animals; Corrinoids; Dogs; Gastroenteritis; Hematinics; Vitamin B 12; Vitamin B Complex